Protective effects of lupeol and mango extract against androgen induced oxidative stress in Swiss albino mice
Aim： To investigate antioxidant potential of lupeol/mango pulp extract （MPE） in testosterone induced oxidative stress in prostate of male Swiss albino mice. Methods： Oral treatment of lupeol （1 mg/animal） and MPE （1 mL [20% w/v]/ animal） was given separately to animals along with subcutaneous inject...
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| Veröffentlicht in: | Asian journal of andrology 2008-03, Vol.10 (2), p.313-318 |
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| creator | Prasad, Sahdeo Kalra, Neetu Singh, Madhulika Shukla, Yogeshwer |
| description | Aim： To investigate antioxidant potential of lupeol/mango pulp extract （MPE） in testosterone induced oxidative stress in prostate of male Swiss albino mice. Methods： Oral treatment of lupeol （1 mg/animal） and MPE （1 mL [20% w/v]/ animal） was given separately to animals along with subcutaneous injection of testosterone （5 mg/kg body weight） consecutively for 15 days. At the end of the study period, the prostate was dissected out for the determination of reactive oxygen species （ROS） levels, lipid peroxidation and antioxidant enzymes status （catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase）. Results： In testosterone treated animals, increased ROS resulted in depletion of antioxidant enzymes and increase in lipid peroxidation in mouse prostate. However, lupeol/MPE treatment resulted in a decrease in ROS levels with restoration in the levels of lipid peroxidation and antioxidant enzymes. Conclusion： The results of the present study demonstrate that lupeol/MPE are effective in combating oxidative stress-induced cellular injury of mouse prostate. Mango and its constituents, therefore, deserve study as a potential chemopreventive agent against prostate cancer. （Asian J Androl 2008 Mar; 10： 313-318） |
| doi_str_mv | 10.1111/j.1745-7262.2008.00313.x |
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Methods： Oral treatment of lupeol （1 mg/animal） and MPE （1 mL [20% w/v]/ animal） was given separately to animals along with subcutaneous injection of testosterone （5 mg/kg body weight） consecutively for 15 days. At the end of the study period, the prostate was dissected out for the determination of reactive oxygen species （ROS） levels, lipid peroxidation and antioxidant enzymes status （catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase）. Results： In testosterone treated animals, increased ROS resulted in depletion of antioxidant enzymes and increase in lipid peroxidation in mouse prostate. However, lupeol/MPE treatment resulted in a decrease in ROS levels with restoration in the levels of lipid peroxidation and antioxidant enzymes. Conclusion： The results of the present study demonstrate that lupeol/MPE are effective in combating oxidative stress-induced cellular injury of mouse prostate. Mango and its constituents, therefore, deserve study as a potential chemopreventive agent against prostate cancer. （Asian J Androl 2008 Mar; 10： 313-318）</description><identifier>ISSN: 1008-682X</identifier><identifier>EISSN: 1745-7262</identifier><identifier>DOI: 10.1111/j.1745-7262.2008.00313.x</identifier><identifier>PMID: 18097535</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; antioxidant enzymes ; Antioxidants - pharmacology ; Catalase - metabolism ; Glutathione Reductase - metabolism ; Glutathione Transferase - metabolism ; Lipid Peroxidation - drug effects ; lupeol ; Male ; Mangifera ; mango pulp extract ; Mice ; oxidative stress ; Oxidative Stress - drug effects ; Pentacyclic Triterpenes ; Plant Extracts - administration & dosage ; Prostate - drug effects ; Prostate - enzymology ; prostate cancer ; Reactive Oxygen Species - metabolism ; Superoxide Dismutase - metabolism ; testosterone ; Testosterone - administration & dosage ; Triterpenes - administration & dosage ; 前列腺癌 ; 氧化特性 ; 睾丸激素 ; 芒果浆萃取物</subject><ispartof>Asian journal of andrology, 2008-03, Vol.10 (2), p.313-318</ispartof><rights>2008, Asian Journal of Andrology, SIMM and SJTU. 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Methods： Oral treatment of lupeol （1 mg/animal） and MPE （1 mL [20% w/v]/ animal） was given separately to animals along with subcutaneous injection of testosterone （5 mg/kg body weight） consecutively for 15 days. At the end of the study period, the prostate was dissected out for the determination of reactive oxygen species （ROS） levels, lipid peroxidation and antioxidant enzymes status （catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase）. Results： In testosterone treated animals, increased ROS resulted in depletion of antioxidant enzymes and increase in lipid peroxidation in mouse prostate. However, lupeol/MPE treatment resulted in a decrease in ROS levels with restoration in the levels of lipid peroxidation and antioxidant enzymes. Conclusion： The results of the present study demonstrate that lupeol/MPE are effective in combating oxidative stress-induced cellular injury of mouse prostate. 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| subjects | Animals antioxidant enzymes Antioxidants - pharmacology Catalase - metabolism Glutathione Reductase - metabolism Glutathione Transferase - metabolism Lipid Peroxidation - drug effects lupeol Male Mangifera mango pulp extract Mice oxidative stress Oxidative Stress - drug effects Pentacyclic Triterpenes Plant Extracts - administration & dosage Prostate - drug effects Prostate - enzymology prostate cancer Reactive Oxygen Species - metabolism Superoxide Dismutase - metabolism testosterone Testosterone - administration & dosage Triterpenes - administration & dosage 前列腺癌 氧化特性 睾丸激素 芒果浆萃取物 |
| title | Protective effects of lupeol and mango extract against androgen induced oxidative stress in Swiss albino mice |
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