Protective effect of taurine on rats with experimental insulin-dependent diabetes mellitus
Taurine had the hypoglycemic effect during experimental insulin-dependent diabetes mellitus and decreased the concentrations of glucose and fructosamine, and increased the contents of insulin, C-peptide, and glycogen in the liver. Studying the dynamics of structural changes in pancreatic tissue conf...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2008-08, Vol.146 (2), p.226-228 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Gavrovskaya, L. K Ryzhova, O. V Safonova, A. F Matveev, A. K Sapronov, N. S |
| description | Taurine had the hypoglycemic effect during experimental insulin-dependent diabetes mellitus and decreased the concentrations of glucose and fructosamine, and increased the contents of insulin, C-peptide, and glycogen in the liver. Studying the dynamics of structural changes in pancreatic tissue confirmed a positive effect of taurine on β-cell function. The protective effect of taurine manifested in the absence of morphological signs for alloxan-induced diabetes: decrease in the number and size of pancreatic islets, change in their distribution, reduction of β-cell count, and accumulation of homogeneous deposits in islets. |
| doi_str_mv | 10.1007/s10517-008-0258-4 |
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The protective effect of taurine manifested in the absence of morphological signs for alloxan-induced diabetes: decrease in the number and size of pancreatic islets, change in their distribution, reduction of β-cell count, and accumulation of homogeneous deposits in islets.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-008-0258-4</identifier><identifier>PMID: 19145324</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Biophysics and Biochemistry ; Body Weight - drug effects ; C-Peptide - metabolism ; Cell Biology ; Cell Count ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - pathology ; Diabetes Mellitus, Experimental - physiopathology ; Diabetes Mellitus, Type 1 - chemically induced ; Diabetes Mellitus, Type 1 - drug therapy ; Diabetes Mellitus, Type 1 - pathology ; Diabetes Mellitus, Type 1 - physiopathology ; Diuresis - drug effects ; Drinking - drug effects ; Fructosamine - metabolism ; Glucose - metabolism ; Glycogen - metabolism ; Hypoglycemic Agents - therapeutic use ; hypoglycemic and protective effect of taurine ; Insulin - metabolism ; insulin-dependent diabetes mellitus ; Insulin-Secreting Cells - drug effects ; Internal Medicine ; Laboratory Medicine ; Liver - metabolism ; Male ; Pancreas - pathology ; Pancreas - physiopathology ; Pathology ; Rats ; Taurine - therapeutic use</subject><ispartof>Bulletin of experimental biology and medicine, 2008-08, Vol.146 (2), p.226-228</ispartof><rights>Springer Science+Business Media, Inc. 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-69f12e6fbc8a61ce618c2dbf6099b9412a938b00716a4e48311324f9db6e338d3</citedby><cites>FETCH-LOGICAL-c393t-69f12e6fbc8a61ce618c2dbf6099b9412a938b00716a4e48311324f9db6e338d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-008-0258-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-008-0258-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19145324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gavrovskaya, L. 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| subjects | Animals Biomedical and Life Sciences Biomedicine Biophysics and Biochemistry Body Weight - drug effects C-Peptide - metabolism Cell Biology Cell Count Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Type 1 - chemically induced Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - pathology Diabetes Mellitus, Type 1 - physiopathology Diuresis - drug effects Drinking - drug effects Fructosamine - metabolism Glucose - metabolism Glycogen - metabolism Hypoglycemic Agents - therapeutic use hypoglycemic and protective effect of taurine Insulin - metabolism insulin-dependent diabetes mellitus Insulin-Secreting Cells - drug effects Internal Medicine Laboratory Medicine Liver - metabolism Male Pancreas - pathology Pancreas - physiopathology Pathology Rats Taurine - therapeutic use |
| title | Protective effect of taurine on rats with experimental insulin-dependent diabetes mellitus |
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