A phase I/II study of nedaplatin and 5-fluorouracil with concurrent radiotherapy in patients with esophageal cancer

To determine the recommended dose (RD) of cis-diammine-glycolatoplatinum (nedaplatin) when given concurrently with 5-FU and high dose radiation therapy in the treatment of esophageal cancer. The purpose of the phase II trial is to determine efficacy and further define the side effect profile. Twenty...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2006-11, Vol.58 (5), p.570-576
Hauptverfasser:	SATO, Yasushi, TAKAYAMA, Tetsuji, TAKIMOTO, Rishu, NAGAKURA, Hisayasu, HAREYAMA, Masato, KATO, Junji, NIITSU, Yoshiro, SAGAWA, Tamotsu, OKAMOTO, Tetsuro, MIYANISHI, Koji, SATO, Tsutomu, ARAKI, Hironobu, LYAMA, Satoshi, ABE, Seiichiro, MURASE, Kazuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anemia - chemically induced Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Dose-Response Relationship, Drug Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophageal Neoplasms - therapy Esophagitis - chemically induced Esophagus Female Fluorouracil - administration & dosage Fluorouracil - adverse effects Gastroenterology. Liver. Pancreas. Abdomen Humans Infusions, Intravenous Male Medical sciences Middle Aged Nausea - chemically induced Neutropenia - chemically induced Organoplatinum Compounds - administration & dosage Organoplatinum Compounds - adverse effects Pharmacology. Drug treatments Radiotherapy, Adjuvant - adverse effects Radiotherapy, Adjuvant - methods Remission Induction Severity of Illness Index Survival Rate Thrombocytopenia - chemically induced Treatment Outcome Tumors
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