Elastic modulus of the thin filament under normal conditions and during heart failure
We developed an original approach to prepare samples for electron microscopy in electric field allowing calculation of the Youngs modulus of the thin filament in a direction perpendicular to the axis of the filament (longitudinal to the protomer) under normal conditions and during heart failure indu...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2004-05, Vol.137 (5), p.435-439 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Samsonidze, E G Karsanov, N V |
| description | We developed an original approach to prepare samples for electron microscopy in electric field allowing calculation of the Youngs modulus of the thin filament in a direction perpendicular to the axis of the filament (longitudinal to the protomer) under normal conditions and during heart failure induced by 10-day toxic and allergic myocarditis. Electric field stretches thin filaments in the transverse direction and the increase in its diameter linearly depends on the applied voltage. The elastic modulus was in inverse proportion to the applied voltage. We found that during heart failure thin filament had an extreme conformation and to a great extent lost its mobility. |
| doi_str_mv | 10.1023/B:BEBM.0000038146.83562.b2 |
| format | Article |
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Electric field stretches thin filaments in the transverse direction and the increase in its diameter linearly depends on the applied voltage. The elastic modulus was in inverse proportion to the applied voltage. We found that during heart failure thin filament had an extreme conformation and to a great extent lost its mobility.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1023/B:BEBM.0000038146.83562.b2</identifier><identifier>PMID: 15455111</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Cardiac Output, Low - pathology ; Cardiac Output, Low - physiopathology ; Elasticity ; Electricity ; Electrophysiology - methods ; Heart - physiology ; Heart - physiopathology ; Microscopy, Electron ; Myocardium - ultrastructure ; Rabbits ; Sarcomeres - physiology ; Sarcomeres - ultrastructure</subject><ispartof>Bulletin of experimental biology and medicine, 2004-05, Vol.137 (5), p.435-439</ispartof><rights>Copyright (c) 2004 Plenum Publishing Corporation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15455111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Samsonidze, E G</creatorcontrib><creatorcontrib>Karsanov, N V</creatorcontrib><title>Elastic modulus of the thin filament under normal conditions and during heart failure</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><description>We developed an original approach to prepare samples for electron microscopy in electric field allowing calculation of the Youngs modulus of the thin filament in a direction perpendicular to the axis of the filament (longitudinal to the protomer) under normal conditions and during heart failure induced by 10-day toxic and allergic myocarditis. Electric field stretches thin filaments in the transverse direction and the increase in its diameter linearly depends on the applied voltage. The elastic modulus was in inverse proportion to the applied voltage. We found that during heart failure thin filament had an extreme conformation and to a great extent lost its mobility.</description><subject>Animals</subject><subject>Cardiac Output, Low - pathology</subject><subject>Cardiac Output, Low - physiopathology</subject><subject>Elasticity</subject><subject>Electricity</subject><subject>Electrophysiology - methods</subject><subject>Heart - physiology</subject><subject>Heart - physiopathology</subject><subject>Microscopy, Electron</subject><subject>Myocardium - ultrastructure</subject><subject>Rabbits</subject><subject>Sarcomeres - physiology</subject><subject>Sarcomeres - ultrastructure</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpFkE1PwzAMhiMEYmPwF1C0e0u-2ma7sWl8SENc2DlKk5RlapORNAf-PS2bNEuWZfm1X-sBYI5RjhGhT6vlarP6yNEYlGNW5pwWJclrcgWmuKhoxgnB12A6zKuMcc4n4C7Gw9iiEt-CCS5YUWCMp2C3aWXsrYKd16lNEfoG9nszpHWwsa3sjOthctoE6HzoZAuVd9r21rsIpdNQp2DdN9wbGXrYSNumYO7BTSPbaB7OdQZ2L5uv9Vu2_Xx9Xz9vM0V40Q9vaiNVUxGNOJOLGi-YNHTBVKmqhhOsZENrhBk3FClTFgQhhjXSBNGK11zTGZif7h6D_0km9uLgU3CDpSCYMk7Lgg-i5Umkgo8xmEYcg-1k-BUYiRGoWIkRqLgAFf9ARU2G5cezQ6o7oy-rZ4L0D0BxcjU</recordid><startdate>200405</startdate><enddate>200405</enddate><creator>Samsonidze, E G</creator><creator>Karsanov, N V</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>200405</creationdate><title>Elastic modulus of the thin filament under normal conditions and during heart failure</title><author>Samsonidze, E G ; 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| ispartof | Bulletin of experimental biology and medicine, 2004-05, Vol.137 (5), p.435-439 |
| issn | 0007-4888 1573-8221 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Cardiac Output, Low - pathology Cardiac Output, Low - physiopathology Elasticity Electricity Electrophysiology - methods Heart - physiology Heart - physiopathology Microscopy, Electron Myocardium - ultrastructure Rabbits Sarcomeres - physiology Sarcomeres - ultrastructure |
| title | Elastic modulus of the thin filament under normal conditions and during heart failure |
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