Combined effects of toxicants with various mechanisms of action and mechanical trauma on the immune system
Experiments on Wistar rats showed that the combined action of mechanical trauma and organophosphorus compound dimethyl dichlorovinyl phosphate a dose of 0.8 LD50 was accompanied by summation of their immunosuppressive effects. We observed an additive effect in relation to stimulation of the adrenal...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2002-06, Vol.133 (6), p.594 |
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| creator | Zabrodskii, P F Germanchuk, V G Kirichuk, V F Birbin, V S Chuev, A N |
| description | Experiments on Wistar rats showed that the combined action of mechanical trauma and organophosphorus compound dimethyl dichlorovinyl phosphate a dose of 0.8 LD50 was accompanied by summation of their immunosuppressive effects. We observed an additive effect in relation to stimulation of the adrenal cortex. Treatment with general chemical toxicants (acrylic acid nitrile and acetonitrile, 0.8 LD50) alone or in combination with mechanical trauma produced similar increase in plasma corticosterone concentration. This effect was short-lasting and less pronounced compared to the influence of dimethyl dichlorovinyl phosphate. The immunosuppressive effect of trauma and nitriles is primarily related to the influence of poisons. |
| doi_str_mv | 10.1023/A:1020298212422 |
| format | Article |
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| ispartof | Bulletin of experimental biology and medicine, 2002-06, Vol.133 (6), p.594 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acetonitriles - toxicity Acrylonitrile - toxicity Adrenal Cortex - drug effects Animals Corticosterone - blood Dichlorvos - poisoning Drug Interactions Immune System - drug effects Insecticides - poisoning Lethal Dose 50 Male Organophosphate Poisoning Rats Rats, Wistar Wounds and Injuries - immunology |
| title | Combined effects of toxicants with various mechanisms of action and mechanical trauma on the immune system |
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