Insights into regulatory roles of MAPK-cascaded pathways in multiple stress responses and life cycles of insect and nematode mycopathogens
Fungal entomopathogenicity may have evolved at least 200 million years later than carnivorism of nematophagous fungi on Earth. This mini-review focuses on the composition and regulatory roles of mitogen-activated protein kinase (MAPK) cascades, which act as stress-responsive signaling pathways. Unve...
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| description | Fungal entomopathogenicity may have evolved at least 200 million years later than carnivorism of nematophagous fungi on Earth. This mini-review focuses on the composition and regulatory roles of mitogen-activated protein kinase (MAPK) cascades, which act as stress-responsive signaling pathways. Unveiled by genomic comparison, three MAPK cascades of these mycopathogens consist of singular MAPKs (Fus3/Hog1/Slt2), MAPK kinases (Ste7/Pbs2/Mkk1), and MAPK kinase kinases (Ste11/Ssk2/Bck1). All cascaded components characterized in fungal entomopathogens play conserved and special roles in regulating multiple stress responses and phenotypes associated with biological control potential. Fus3-cascaded components are indispensable for fungal growth on oligotrophic substrata and virulence, and mediate cell tolerance to Na
+
/K
+
toxicity, which is often misinterpreted as hyperosmotic effect but readily clarified by transcriptional changes of Na
+
/K
+
ATPase genes and/or cell responses to osmotic polyols. Hog1-cascaded components regulate osmotolerance positively and phenylpyrrole-type fungicide resistance negatively, and also play differential roles in cell growth, conidiation, virulence, and responses to other stress cues. Ste11 has no stress-responsive role in the
Beauveria
Hog1 cascade despite an essential role in branched yeast Hog1 cascade. Slt2-cascaded components are required for mediation of cell wall integrity and repair of cell wall damage. A crosstalk between Hog1 and Slt2 cascades ensures fungal osmotolerance inside or outside insect. In nematode-trapping fungi, Slt2 is indispensable for cell wall integrity, conidiation, and mycelial trap formation, suggesting that the Slt2 cascade could have evolved along a distinct trajectory required for fungal carnivorism and dispersal/survival in nematode habitats. Altogether, the MAPK cascades are major parts of signaling network that regulate fungal adaptation to insects and nematodes and their habitats. |
| doi_str_mv | 10.1007/s00253-018-9516-1 |
| format | Article |
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+
/K
+
toxicity, which is often misinterpreted as hyperosmotic effect but readily clarified by transcriptional changes of Na
+
/K
+
ATPase genes and/or cell responses to osmotic polyols. Hog1-cascaded components regulate osmotolerance positively and phenylpyrrole-type fungicide resistance negatively, and also play differential roles in cell growth, conidiation, virulence, and responses to other stress cues. Ste11 has no stress-responsive role in the
Beauveria
Hog1 cascade despite an essential role in branched yeast Hog1 cascade. Slt2-cascaded components are required for mediation of cell wall integrity and repair of cell wall damage. A crosstalk between Hog1 and Slt2 cascades ensures fungal osmotolerance inside or outside insect. In nematode-trapping fungi, Slt2 is indispensable for cell wall integrity, conidiation, and mycelial trap formation, suggesting that the Slt2 cascade could have evolved along a distinct trajectory required for fungal carnivorism and dispersal/survival in nematode habitats. Altogether, the MAPK cascades are major parts of signaling network that regulate fungal adaptation to insects and nematodes and their habitats.</description><identifier>ISSN: 0175-7598</identifier><identifier>EISSN: 1432-0614</identifier><identifier>DOI: 10.1007/s00253-018-9516-1</identifier><identifier>PMID: 30448905</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>ATPases ; Biological control ; Biological pest control ; Biomedical and Life Sciences ; Biotechnology ; Cascades ; Cell walls ; Crosstalk ; Dispersal ; Fungi ; Fungicides ; Genes ; Hog1 protein ; Insects ; Integrity ; Kinases ; Life cycles ; Life cycles (Biology) ; Life Sciences ; MAP kinase ; Mediation ; Microbial Genetics and Genomics ; Microbiology ; Mini-Review ; Mitogen-activated protein kinases ; Mitogens ; Mycelia ; Na+/K+-exchanging ATPase ; Nematodes ; Nematophagous fungi ; Observations ; Phenotypes ; Physiological aspects ; Polyols ; Protein kinase ; Protein kinases ; Proteins ; Roles ; Roundworms ; Signal transduction ; Signaling ; Stresses ; Toxicity ; Transcription ; Transcription (Genetics) ; Virulence ; Yeast ; Yeasts</subject><ispartof>Applied microbiology and biotechnology, 2019-01, Vol.103 (2), p.577-587</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Applied Microbiology and Biotechnology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-5a28b029d5782a59b7311478275f89544dc16ed82236e7d7ee13be40d5a950d03</citedby><cites>FETCH-LOGICAL-c473t-5a28b029d5782a59b7311478275f89544dc16ed82236e7d7ee13be40d5a950d03</cites><orcidid>0000-0002-2657-0293</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00253-018-9516-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00253-018-9516-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30448905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tong, Sen-Miao</creatorcontrib><creatorcontrib>Feng, Ming-Guang</creatorcontrib><title>Insights into regulatory roles of MAPK-cascaded pathways in multiple stress responses and life cycles of insect and nematode mycopathogens</title><title>Applied microbiology and biotechnology</title><addtitle>Appl Microbiol Biotechnol</addtitle><addtitle>Appl Microbiol Biotechnol</addtitle><description>Fungal entomopathogenicity may have evolved at least 200 million years later than carnivorism of nematophagous fungi on Earth. This mini-review focuses on the composition and regulatory roles of mitogen-activated protein kinase (MAPK) cascades, which act as stress-responsive signaling pathways. Unveiled by genomic comparison, three MAPK cascades of these mycopathogens consist of singular MAPKs (Fus3/Hog1/Slt2), MAPK kinases (Ste7/Pbs2/Mkk1), and MAPK kinase kinases (Ste11/Ssk2/Bck1). All cascaded components characterized in fungal entomopathogens play conserved and special roles in regulating multiple stress responses and phenotypes associated with biological control potential. Fus3-cascaded components are indispensable for fungal growth on oligotrophic substrata and virulence, and mediate cell tolerance to Na
+
/K
+
toxicity, which is often misinterpreted as hyperosmotic effect but readily clarified by transcriptional changes of Na
+
/K
+
ATPase genes and/or cell responses to osmotic polyols. Hog1-cascaded components regulate osmotolerance positively and phenylpyrrole-type fungicide resistance negatively, and also play differential roles in cell growth, conidiation, virulence, and responses to other stress cues. Ste11 has no stress-responsive role in the
Beauveria
Hog1 cascade despite an essential role in branched yeast Hog1 cascade. Slt2-cascaded components are required for mediation of cell wall integrity and repair of cell wall damage. A crosstalk between Hog1 and Slt2 cascades ensures fungal osmotolerance inside or outside insect. In nematode-trapping fungi, Slt2 is indispensable for cell wall integrity, conidiation, and mycelial trap formation, suggesting that the Slt2 cascade could have evolved along a distinct trajectory required for fungal carnivorism and dispersal/survival in nematode habitats. Altogether, the MAPK cascades are major parts of signaling network that regulate fungal adaptation to insects and nematodes and their habitats.</description><subject>ATPases</subject><subject>Biological control</subject><subject>Biological pest control</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Cascades</subject><subject>Cell walls</subject><subject>Crosstalk</subject><subject>Dispersal</subject><subject>Fungi</subject><subject>Fungicides</subject><subject>Genes</subject><subject>Hog1 protein</subject><subject>Insects</subject><subject>Integrity</subject><subject>Kinases</subject><subject>Life cycles</subject><subject>Life cycles (Biology)</subject><subject>Life Sciences</subject><subject>MAP kinase</subject><subject>Mediation</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>Mini-Review</subject><subject>Mitogen-activated protein kinases</subject><subject>Mitogens</subject><subject>Mycelia</subject><subject>Na+/K+-exchanging ATPase</subject><subject>Nematodes</subject><subject>Nematophagous fungi</subject><subject>Observations</subject><subject>Phenotypes</subject><subject>Physiological aspects</subject><subject>Polyols</subject><subject>Protein kinase</subject><subject>Protein kinases</subject><subject>Proteins</subject><subject>Roles</subject><subject>Roundworms</subject><subject>Signal transduction</subject><subject>Signaling</subject><subject>Stresses</subject><subject>Toxicity</subject><subject>Transcription</subject><subject>Transcription (Genetics)</subject><subject>Virulence</subject><subject>Yeast</subject><subject>Yeasts</subject><issn>0175-7598</issn><issn>1432-0614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1ks1u1DAUhSMEokPhAdggS6xYpNiOHSfLUcXPiCIQP2vLY9-kqZI4-DqCvEKfug4zUI0EK1u-3znX1z5Z9pzRC0apeo2UclnklFV5LVmZswfZhomC57Rk4mG2oUzJXMm6OsueIN5QynhVlo-zs4IKUdVUbrLb3Yhdex2RdGP0JEA79yb6sJDge0DiG_Jx-_lDbg1a48CRycTrn2ZZeTLMfeymHgjGAIhJjZMfMcnM6EjfNUDsYo82XSrY-LsywpB6OCDDYv1q6FsY8Wn2qDE9wrPjep59f_vm2-X7_OrTu93l9iq3QhUxl4ZXe8prJ1XFjaz3qmBMpL2STVVLIZxlJbiK86IE5RQAK_YgqJOmltTR4jx7efCdgv8xA0Z94-cwppaas0KUVJSK3VOt6UF3Y-NjMHbo0OqtVFxVJVNFoi7-QZn1qYbO-hGaLp2fCF6dCBIT4VdszYyod1-_nLLswNrgEQM0egrdYMKiGdVrAPQhADoFQK8B0Ou1XxyHm_cDuL-KPz-eAH4AMJXGFsL99P93vQMKw7oj</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Tong, 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into regulatory roles of MAPK-cascaded pathways in multiple stress responses and life cycles of insect and nematode mycopathogens</title><author>Tong, Sen-Miao ; Feng, Ming-Guang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-5a28b029d5782a59b7311478275f89544dc16ed82236e7d7ee13be40d5a950d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>ATPases</topic><topic>Biological control</topic><topic>Biological pest control</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Cascades</topic><topic>Cell walls</topic><topic>Crosstalk</topic><topic>Dispersal</topic><topic>Fungi</topic><topic>Fungicides</topic><topic>Genes</topic><topic>Hog1 protein</topic><topic>Insects</topic><topic>Integrity</topic><topic>Kinases</topic><topic>Life cycles</topic><topic>Life cycles (Biology)</topic><topic>Life Sciences</topic><topic>MAP 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Biotechnol</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>103</volume><issue>2</issue><spage>577</spage><epage>587</epage><pages>577-587</pages><issn>0175-7598</issn><eissn>1432-0614</eissn><abstract>Fungal entomopathogenicity may have evolved at least 200 million years later than carnivorism of nematophagous fungi on Earth. This mini-review focuses on the composition and regulatory roles of mitogen-activated protein kinase (MAPK) cascades, which act as stress-responsive signaling pathways. Unveiled by genomic comparison, three MAPK cascades of these mycopathogens consist of singular MAPKs (Fus3/Hog1/Slt2), MAPK kinases (Ste7/Pbs2/Mkk1), and MAPK kinase kinases (Ste11/Ssk2/Bck1). All cascaded components characterized in fungal entomopathogens play conserved and special roles in regulating multiple stress responses and phenotypes associated with biological control potential. Fus3-cascaded components are indispensable for fungal growth on oligotrophic substrata and virulence, and mediate cell tolerance to Na
+
/K
+
toxicity, which is often misinterpreted as hyperosmotic effect but readily clarified by transcriptional changes of Na
+
/K
+
ATPase genes and/or cell responses to osmotic polyols. Hog1-cascaded components regulate osmotolerance positively and phenylpyrrole-type fungicide resistance negatively, and also play differential roles in cell growth, conidiation, virulence, and responses to other stress cues. Ste11 has no stress-responsive role in the
Beauveria
Hog1 cascade despite an essential role in branched yeast Hog1 cascade. Slt2-cascaded components are required for mediation of cell wall integrity and repair of cell wall damage. A crosstalk between Hog1 and Slt2 cascades ensures fungal osmotolerance inside or outside insect. In nematode-trapping fungi, Slt2 is indispensable for cell wall integrity, conidiation, and mycelial trap formation, suggesting that the Slt2 cascade could have evolved along a distinct trajectory required for fungal carnivorism and dispersal/survival in nematode habitats. Altogether, the MAPK cascades are major parts of signaling network that regulate fungal adaptation to insects and nematodes and their habitats.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30448905</pmid><doi>10.1007/s00253-018-9516-1</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2657-0293</orcidid></addata></record> |
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| ispartof | Applied microbiology and biotechnology, 2019-01, Vol.103 (2), p.577-587 |
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| source | SpringerLink Journals |
| subjects | ATPases Biological control Biological pest control Biomedical and Life Sciences Biotechnology Cascades Cell walls Crosstalk Dispersal Fungi Fungicides Genes Hog1 protein Insects Integrity Kinases Life cycles Life cycles (Biology) Life Sciences MAP kinase Mediation Microbial Genetics and Genomics Microbiology Mini-Review Mitogen-activated protein kinases Mitogens Mycelia Na+/K+-exchanging ATPase Nematodes Nematophagous fungi Observations Phenotypes Physiological aspects Polyols Protein kinase Protein kinases Proteins Roles Roundworms Signal transduction Signaling Stresses Toxicity Transcription Transcription (Genetics) Virulence Yeast Yeasts |
| title | Insights into regulatory roles of MAPK-cascaded pathways in multiple stress responses and life cycles of insect and nematode mycopathogens |
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