Alleviation of side effects induced by irinotecan hydrochloride (CPT-11) in rats by intravenous infusion

Irinotecan hydrochloride (CPT-11) is a potent topoisomerase I inhibitor and is established and used widely as an antitumor agent. However, it sometimes causes severe side effects such as myelosuppression and diarrhea. These dose-limiting toxicities prevent the adoption of CPT-11 in aggressive chemot...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2003-11, Vol.52 (5), p.349-360
Hauptverfasser:	KURITA, Akinobu, KADO, Shoichi, KANEDA, Norimasa, ONOUE, Masaharu, HASHIMOTO, Shusuke, YOKOKURA, Teruo
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - adverse effects Antineoplastic Agents, Phytogenic - pharmacokinetics Area Under Curve Bile - metabolism Biological and medical sciences Biotransformation Blood Cell Count Body Weight - drug effects Bone Marrow - metabolism Bone Marrow Diseases - chemically induced Bone Marrow Diseases - pathology Bone Marrow Diseases - prevention & control Camptothecin - administration & dosage Camptothecin - adverse effects Camptothecin - analogs & derivatives Camptothecin - pharmacokinetics Diarrhea - chemically induced Diarrhea - pathology Diarrhea - prevention & control Drug toxicity and drugs side effects treatment Infusions, Intravenous Intestines - pathology Male Medical sciences Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Toxicity: blood Toxicity: digestive system
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