Mechanisms underlying cytotoxicity of anti-DNA antibodies

We studied mechanisms underlying cytotoxicity of catalytic anti-DNA autoantibodies or DNA abzymes isolated from the blood of patients with systemic lupus erythematosus and autoimmune mice. Experiments were performed on L929, HL-60, Raji, and K562 cells. Treatment with DNA abzymes caused internucleos...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2001-05, Vol.131 (5), p.475
1. Verfasser:	Suchkov, S V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - toxicity Apoptosis Cell Line Cell Membrane - metabolism DNA - immunology DNA - metabolism DNA Fragmentation Flow Cytometry Humans Lupus Erythematosus, Systemic - blood Mice Mice, Inbred BALB C Mice, Inbred MRL lpr Microscopy, Fluorescence Phosphatidylserines - metabolism Time Factors
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