CHLORPROPAMIDE ALCOHOL FLUSHING AND DIABETIC RETINOPATHY
"Mason-type" diabetics (mild diabetes which is dominantly inherited) are relatively free of retinopathy. Alcohol almost invariably causes facial flushing in these patients when they are given chlorpropamide (chlorpropamide alcohol flush, C.P.A.F.). 291 non-insulin-dependent diabetics were...
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| Veröffentlicht in: | The Lancet (British edition) 1979-05, Vol.313 (8124), p.997-999 |
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| creator | Leslie, R.D.G. Barnett, A.H. Pyke, D.A. |
| description | "Mason-type" diabetics (mild diabetes which is dominantly inherited) are relatively free of retinopathy. Alcohol almost invariably causes facial flushing in these patients when they are given chlorpropamide (chlorpropamide alcohol flush, C.P.A.F.). 291 non-insulin-dependent diabetics were examined to see whether there was a difference in frequency of retinopathy between C.P.A.F. positive and negative cases who were of comparable age and duration of diabetes. Retinopathy was commoner and often severe in C.P.A.F.-negative patients. Blindness from retinopathy was almost confined to C.P.A.F.-negative cases. Lens opacities, on the other hand, were equally common in both groups. Since C.P.A.F. is an inherited trait, retinopathy in non-insulin-dependent diabetics is to a considerable extent, although not entirely, determined by genetic factors. |
| doi_str_mv | 10.1016/S0140-6736(79)92753-3 |
| format | Article |
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Alcohol almost invariably causes facial flushing in these patients when they are given chlorpropamide (chlorpropamide alcohol flush, C.P.A.F.). 291 non-insulin-dependent diabetics were examined to see whether there was a difference in frequency of retinopathy between C.P.A.F. positive and negative cases who were of comparable age and duration of diabetes. Retinopathy was commoner and often severe in C.P.A.F.-negative patients. Blindness from retinopathy was almost confined to C.P.A.F.-negative cases. Lens opacities, on the other hand, were equally common in both groups. Since C.P.A.F. is an inherited trait, retinopathy in non-insulin-dependent diabetics is to a considerable extent, although not entirely, determined by genetic factors.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(79)92753-3</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Alcohol ; Alcohols ; Blindness ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (insulin dependent) ; Diabetes mellitus (non-insulin dependent) ; Diabetic retinopathy ; Flushing ; Genetic factors ; Insulin ; Patients ; Retinopathy</subject><ispartof>The Lancet (British edition), 1979-05, Vol.313 (8124), p.997-999</ispartof><rights>1979</rights><rights>Copyright Elsevier Limited May 12, 1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c250t-1e287696dc2915ba64de5a40ed6d99969fe342d4da64c35574de9052fef61ddc3</citedby><cites>FETCH-LOGICAL-c250t-1e287696dc2915ba64de5a40ed6d99969fe342d4da64c35574de9052fef61ddc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0140673679927533$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids></links><search><creatorcontrib>Leslie, R.D.G.</creatorcontrib><creatorcontrib>Barnett, A.H.</creatorcontrib><creatorcontrib>Pyke, D.A.</creatorcontrib><title>CHLORPROPAMIDE ALCOHOL FLUSHING AND DIABETIC RETINOPATHY</title><title>The Lancet (British edition)</title><description>"Mason-type" diabetics (mild diabetes which is dominantly inherited) are relatively free of retinopathy. Alcohol almost invariably causes facial flushing in these patients when they are given chlorpropamide (chlorpropamide alcohol flush, C.P.A.F.). 291 non-insulin-dependent diabetics were examined to see whether there was a difference in frequency of retinopathy between C.P.A.F. positive and negative cases who were of comparable age and duration of diabetes. Retinopathy was commoner and often severe in C.P.A.F.-negative patients. Blindness from retinopathy was almost confined to C.P.A.F.-negative cases. Lens opacities, on the other hand, were equally common in both groups. Since C.P.A.F. is an inherited trait, retinopathy in non-insulin-dependent diabetics is to a considerable extent, although not entirely, determined by genetic factors.</description><subject>Alcohol</subject><subject>Alcohols</subject><subject>Blindness</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetic retinopathy</subject><subject>Flushing</subject><subject>Genetic factors</subject><subject>Insulin</subject><subject>Patients</subject><subject>Retinopathy</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><recordid>eNqFkEtLw0AUhQdRsFZ_ghBwo4vovKezkpi0TSA2pQ_Q1RBnJpCiTZ1pBf-901bcurl3cc85l_MBcI3gPYKIP8whojDmgvBbIe8kFozE5AT0EBU0ZlS8nILen-QcXHi_ghBSDlkPDNK8rGbTWTVNnotsGCVlWuVVGY3K5TwvJuMomWRRViRPw0WRRrMwJ0G6yF8vwVlTv3t79bv7YDkaLtI8LqtxkSZlrDGD2xhZPBBccqOxROyt5tRYVlNoDTdSSi4bSyg21ISLJoyJcJeQ4cY2HBmjSR_cHHM3rvvcWb9Vq27n1uGlwihY2SA0Cyp2VGnXee9sozau_ajdt0JQ7SGpAyS1J6CEVAdIigTf49FnQ4Wv1jrldWvX2prWWb1Vpmv_SfgBxNZoKQ</recordid><startdate>19790512</startdate><enddate>19790512</enddate><creator>Leslie, R.D.G.</creator><creator>Barnett, A.H.</creator><creator>Pyke, D.A.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>ASE</scope><scope>C1K</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>KB~</scope><scope>M7N</scope><scope>NAPCQ</scope></search><sort><creationdate>19790512</creationdate><title>CHLORPROPAMIDE ALCOHOL FLUSHING AND DIABETIC RETINOPATHY</title><author>Leslie, R.D.G. ; Barnett, A.H. ; Pyke, D.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c250t-1e287696dc2915ba64de5a40ed6d99969fe342d4da64c35574de9052fef61ddc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Alcohol</topic><topic>Alcohols</topic><topic>Blindness</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetic retinopathy</topic><topic>Flushing</topic><topic>Genetic factors</topic><topic>Insulin</topic><topic>Patients</topic><topic>Retinopathy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leslie, R.D.G.</creatorcontrib><creatorcontrib>Barnett, A.H.</creatorcontrib><creatorcontrib>Pyke, D.A.</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Newsstand Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leslie, R.D.G.</au><au>Barnett, A.H.</au><au>Pyke, D.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CHLORPROPAMIDE ALCOHOL FLUSHING AND DIABETIC RETINOPATHY</atitle><jtitle>The Lancet (British edition)</jtitle><date>1979-05-12</date><risdate>1979</risdate><volume>313</volume><issue>8124</issue><spage>997</spage><epage>999</epage><pages>997-999</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><abstract>"Mason-type" diabetics (mild diabetes which is dominantly inherited) are relatively free of retinopathy. Alcohol almost invariably causes facial flushing in these patients when they are given chlorpropamide (chlorpropamide alcohol flush, C.P.A.F.). 291 non-insulin-dependent diabetics were examined to see whether there was a difference in frequency of retinopathy between C.P.A.F. positive and negative cases who were of comparable age and duration of diabetes. Retinopathy was commoner and often severe in C.P.A.F.-negative patients. Blindness from retinopathy was almost confined to C.P.A.F.-negative cases. Lens opacities, on the other hand, were equally common in both groups. Since C.P.A.F. is an inherited trait, retinopathy in non-insulin-dependent diabetics is to a considerable extent, although not entirely, determined by genetic factors.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><doi>10.1016/S0140-6736(79)92753-3</doi><tpages>3</tpages></addata></record> |
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| ispartof | The Lancet (British edition), 1979-05, Vol.313 (8124), p.997-999 |
| issn | 0140-6736 1474-547X |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Alcohol Alcohols Blindness Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes mellitus (non-insulin dependent) Diabetic retinopathy Flushing Genetic factors Insulin Patients Retinopathy |
| title | CHLORPROPAMIDE ALCOHOL FLUSHING AND DIABETIC RETINOPATHY |
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