Plasma pharmacokinetics and tissue distribution of the breast cancer resistance protein (BCRP/ABCG2) inhibitor fumitremorgin C in SCID mice bearing T8 tumors

Multidrug resistance (MDR) remains a major obstacle in the treatment of human cancers. The recently discovered breast cancer resistance protein (BCRP/ABCG2) has been found to be an important mediator of chemotherapeutic MDR. Fumitremorgin C (FTC) is a selective and potent inhibitor of BCRP that comp...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2005-02, Vol.55 (2), p.101-109
Hauptverfasser:	GARIMELLA, T. S, ROSS, D. D, EISEMAN, J. L, MONDICK, J. T, JOSEPH, E, NAKANISHI, T, BATES, S. E, BAUER, K. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents ATP Binding Cassette Transporter, Sub-Family G, Member 2 ATP-Binding Cassette Transporters - analysis ATP-Binding Cassette Transporters - antagonists & inhibitors ATP-Binding Cassette Transporters - physiology Biological and medical sciences Cell Line, Tumor Female Humans Indoles - administration & dosage Indoles - pharmacokinetics Medical sciences Mice Mice, SCID Neoplasm Proteins - analysis Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - physiology Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Pharmacology. Drug treatments Tissue Distribution
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