Spontaneous bilateral pneumothorax in metastatic renal cell carcinoma on sunitinib therapy
Bilateral spontaneous pneumothorax is a rare occurrence in patients with both primary and metastatic lung cancer. Pneumothorax occurring as a complication of vascular endothelial growth factor receptor (VEGFR) inhibitor therapy has not been previously described in the medical literature. Sunitinib m...
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| Veröffentlicht in: | Cancer chemotherapy and pharmacology 2010-07, Vol.66 (2), p.409-412 |
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| creator | Katta, Anilkumar Fesler, Mark J Tan, Alan Vuong, Giao Richart, John M |
| description | Bilateral spontaneous pneumothorax is a rare occurrence in patients with both primary and metastatic lung cancer. Pneumothorax occurring as a complication of vascular endothelial growth factor receptor (VEGFR) inhibitor therapy has not been previously described in the medical literature. Sunitinib malate is a VEGFR inhibitor approved for the treatment of advanced renal cell carcinoma. We present a patient with metastatic renal cell carcinoma manifested as bilateral pulmonary nodules who developed a bilateral spontaneous pneumothorax 3 weeks after initiation of sunitinib therapy. We believe that sunitinib therapy resulted in necrosis of multiple pleural-based pulmonary nodules with central cavernization and ultimately rupture with bronchopleural fistula formation. Based on this experience, we advise that practitioners exercise caution when prescribing anti-VEGFR therapy in patients with pleural-based pulmonary metastases and recognize that the efficacy and toxicity of these agents may be closely linked. |
| doi_str_mv | 10.1007/s00280-010-1291-3 |
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Pneumothorax occurring as a complication of vascular endothelial growth factor receptor (VEGFR) inhibitor therapy has not been previously described in the medical literature. Sunitinib malate is a VEGFR inhibitor approved for the treatment of advanced renal cell carcinoma. We present a patient with metastatic renal cell carcinoma manifested as bilateral pulmonary nodules who developed a bilateral spontaneous pneumothorax 3 weeks after initiation of sunitinib therapy. We believe that sunitinib therapy resulted in necrosis of multiple pleural-based pulmonary nodules with central cavernization and ultimately rupture with bronchopleural fistula formation. Based on this experience, we advise that practitioners exercise caution when prescribing anti-VEGFR therapy in patients with pleural-based pulmonary metastases and recognize that the efficacy and toxicity of these agents may be closely linked.</description><identifier>ISSN: 0344-5704</identifier><identifier>EISSN: 1432-0843</identifier><identifier>DOI: 10.1007/s00280-010-1291-3</identifier><identifier>PMID: 20204363</identifier><identifier>CODEN: CCPHDZ</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Adult ; Antineoplastic agents ; Antineoplastic Agents - adverse effects ; Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Cancer Research ; Carcinoma, Renal Cell - complications ; Carcinoma, Renal Cell - drug therapy ; Carcinoma, Renal Cell - pathology ; Humans ; Indoles - adverse effects ; Indoles - therapeutic use ; Interleukin-2 - therapeutic use ; Kidney Neoplasms - complications ; Kidney Neoplasms - drug therapy ; Kidney Neoplasms - pathology ; Kidneys ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Necrosis - pathology ; Neoplasm Metastasis ; Nephrology. Urinary tract diseases ; Oncology ; Pharmacology. Drug treatments ; Pharmacology/Toxicology ; Pneumology ; pneumothorax ; Pneumothorax - chemically induced ; Pneumothorax - diagnostic imaging ; Pulmonary metastasis ; Pyrroles - adverse effects ; Pyrroles - therapeutic use ; Receptors, Vascular Endothelial Growth Factor - drug effects ; Renal cell carcinoma ; Respiratory system : syndromes and miscellaneous diseases ; Short Communication ; Sunitinib ; Tomography, X-Ray Computed ; Tumors of the respiratory system and mediastinum ; Tumors of the urinary system</subject><ispartof>Cancer chemotherapy and pharmacology, 2010-07, Vol.66 (2), p.409-412</ispartof><rights>Springer-Verlag 2010</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-7eaff22e5511187f2279bcb1cc4fa92065f568c8fb4caa52bd1eca6cdcd93b2c3</citedby><cites>FETCH-LOGICAL-c490t-7eaff22e5511187f2279bcb1cc4fa92065f568c8fb4caa52bd1eca6cdcd93b2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00280-010-1291-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00280-010-1291-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22862124$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20204363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katta, Anilkumar</creatorcontrib><creatorcontrib>Fesler, Mark J</creatorcontrib><creatorcontrib>Tan, Alan</creatorcontrib><creatorcontrib>Vuong, Giao</creatorcontrib><creatorcontrib>Richart, John M</creatorcontrib><title>Spontaneous bilateral pneumothorax in metastatic renal cell carcinoma on sunitinib therapy</title><title>Cancer chemotherapy and pharmacology</title><addtitle>Cancer Chemother Pharmacol</addtitle><addtitle>Cancer Chemother Pharmacol</addtitle><description>Bilateral spontaneous pneumothorax is a rare occurrence in patients with both primary and metastatic lung cancer. Pneumothorax occurring as a complication of vascular endothelial growth factor receptor (VEGFR) inhibitor therapy has not been previously described in the medical literature. Sunitinib malate is a VEGFR inhibitor approved for the treatment of advanced renal cell carcinoma. We present a patient with metastatic renal cell carcinoma manifested as bilateral pulmonary nodules who developed a bilateral spontaneous pneumothorax 3 weeks after initiation of sunitinib therapy. We believe that sunitinib therapy resulted in necrosis of multiple pleural-based pulmonary nodules with central cavernization and ultimately rupture with bronchopleural fistula formation. Based on this experience, we advise that practitioners exercise caution when prescribing anti-VEGFR therapy in patients with pleural-based pulmonary metastases and recognize that the efficacy and toxicity of these agents may be closely linked.</description><subject>Adult</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cancer Research</subject><subject>Carcinoma, Renal Cell - complications</subject><subject>Carcinoma, Renal Cell - drug therapy</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Humans</subject><subject>Indoles - adverse effects</subject><subject>Indoles - therapeutic use</subject><subject>Interleukin-2 - therapeutic use</subject><subject>Kidney Neoplasms - complications</subject><subject>Kidney Neoplasms - drug therapy</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Necrosis - pathology</subject><subject>Neoplasm Metastasis</subject><subject>Nephrology. 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Urinary tract diseases</topic><topic>Oncology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pharmacology/Toxicology</topic><topic>Pneumology</topic><topic>pneumothorax</topic><topic>Pneumothorax - chemically induced</topic><topic>Pneumothorax - diagnostic imaging</topic><topic>Pulmonary metastasis</topic><topic>Pyrroles - adverse effects</topic><topic>Pyrroles - therapeutic use</topic><topic>Receptors, Vascular Endothelial Growth Factor - drug effects</topic><topic>Renal cell carcinoma</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Short Communication</topic><topic>Sunitinib</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumors of the respiratory system and mediastinum</topic><topic>Tumors of the urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katta, Anilkumar</creatorcontrib><creatorcontrib>Fesler, Mark J</creatorcontrib><creatorcontrib>Tan, Alan</creatorcontrib><creatorcontrib>Vuong, Giao</creatorcontrib><creatorcontrib>Richart, John M</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Cancer chemotherapy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katta, Anilkumar</au><au>Fesler, Mark J</au><au>Tan, Alan</au><au>Vuong, Giao</au><au>Richart, John M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous bilateral pneumothorax in metastatic renal cell carcinoma on sunitinib therapy</atitle><jtitle>Cancer chemotherapy and pharmacology</jtitle><stitle>Cancer Chemother Pharmacol</stitle><addtitle>Cancer Chemother Pharmacol</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>66</volume><issue>2</issue><spage>409</spage><epage>412</epage><pages>409-412</pages><issn>0344-5704</issn><eissn>1432-0843</eissn><coden>CCPHDZ</coden><abstract>Bilateral spontaneous pneumothorax is a rare occurrence in patients with both primary and metastatic lung cancer. Pneumothorax occurring as a complication of vascular endothelial growth factor receptor (VEGFR) inhibitor therapy has not been previously described in the medical literature. Sunitinib malate is a VEGFR inhibitor approved for the treatment of advanced renal cell carcinoma. We present a patient with metastatic renal cell carcinoma manifested as bilateral pulmonary nodules who developed a bilateral spontaneous pneumothorax 3 weeks after initiation of sunitinib therapy. We believe that sunitinib therapy resulted in necrosis of multiple pleural-based pulmonary nodules with central cavernization and ultimately rupture with bronchopleural fistula formation. Based on this experience, we advise that practitioners exercise caution when prescribing anti-VEGFR therapy in patients with pleural-based pulmonary metastases and recognize that the efficacy and toxicity of these agents may be closely linked.</abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>20204363</pmid><doi>10.1007/s00280-010-1291-3</doi><tpages>4</tpages></addata></record> |
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| ispartof | Cancer chemotherapy and pharmacology, 2010-07, Vol.66 (2), p.409-412 |
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| subjects | Adult Antineoplastic agents Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Biological and medical sciences Cancer Research Carcinoma, Renal Cell - complications Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - pathology Humans Indoles - adverse effects Indoles - therapeutic use Interleukin-2 - therapeutic use Kidney Neoplasms - complications Kidney Neoplasms - drug therapy Kidney Neoplasms - pathology Kidneys Male Medical sciences Medicine Medicine & Public Health Necrosis - pathology Neoplasm Metastasis Nephrology. Urinary tract diseases Oncology Pharmacology. Drug treatments Pharmacology/Toxicology Pneumology pneumothorax Pneumothorax - chemically induced Pneumothorax - diagnostic imaging Pulmonary metastasis Pyrroles - adverse effects Pyrroles - therapeutic use Receptors, Vascular Endothelial Growth Factor - drug effects Renal cell carcinoma Respiratory system : syndromes and miscellaneous diseases Short Communication Sunitinib Tomography, X-Ray Computed Tumors of the respiratory system and mediastinum Tumors of the urinary system |
| title | Spontaneous bilateral pneumothorax in metastatic renal cell carcinoma on sunitinib therapy |
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