Effect of afobazole on teratogenic activity of cyclophosphamide in rats

A new anxiolytic afobazole (1-100 mg/kg perorally, Russia) dose-dependently abolished the embryotoxic and teratogenic effects of cyclophosphamide and reduced the range of induced malformations in outbred albino rats. Our results suggest that afobazole possesses antiteratogenic activity.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2008-04, Vol.145 (4), p.436-439
Hauptverfasser:	Shreder, O. V, Smolnikova, N. M, Durnev, A. D, Seredenin, S. B
Format:	Artikel
Sprache:	eng
Schlagworte:	afobazole Animals Animals, Outbred Strains Anti-Anxiety Agents - pharmacology Benzimidazoles - pharmacology Biomedical and Life Sciences Biomedicine Cell Biology Congenital Abnormalities - pathology Congenital Abnormalities - prevention & control Congenital Abnormalities - veterinary cyclophosphamide Cyclophosphamide - toxicity Cytoprotection - drug effects Dose-Response Relationship, Drug Drug Evaluation, Preclinical Female Fetal Viability - drug effects Internal Medicine Laboratory Medicine Morpholines - pharmacology Pathology Pharmacology and Toxicology Pregnancy Rats teratogenesis Teratogens - toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!