Dermatofibrosarcoma protuberans – the impact of radiation therapy: a single institution series
BackgroundDermatofibrosarcoma protuberans (DFSP) is a locally aggressive intermediate malignancy.ObjectiveThe purpose of this retrospective analysis is to determine the efficacy of radiation therapy (RT) in local control of DFSP.Patients and methodsThe recurrence-free survival (RFS) for 45 patients...
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| Veröffentlicht in: | Journal of radiotherapy in practice 2018-12, Vol.17 (4), p.390-395 |
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| container_title | Journal of radiotherapy in practice |
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| creator | Sebastian, Patricia Siddique, Sharief K. Varghese, Sunitha Susan Prabhu, Anne Jennifer Titus, V. T. K. Backianathan, Selvamani Nayak, Sukriya |
| description | BackgroundDermatofibrosarcoma protuberans (DFSP) is a locally aggressive intermediate malignancy.ObjectiveThe purpose of this retrospective analysis is to determine the efficacy of radiation therapy (RT) in local control of DFSP.Patients and methodsThe recurrence-free survival (RFS) for 45 patients treated for DFSP at our institution was estimated and compared between surgery alone and postoperative RT groups.ResultsAge range of the patients were in the third and fourth decades; males:females=2:1; most common site: anterior abdominal wall; tumours >5 cm in size in 75%; low grade in 77·8%; margins positive in 31·8% and 50 Gy in 88% of patients. The patients treated with postoperative RT had poorer prognostic factors compared with surgery alone: they were males (17 versus 13 patients), and presented with high-grade tumours (5 versus 1 patients), multiple recurrences prior to presentation (25 versus 20 patients) and positive or |
| doi_str_mv | 10.1017/S1460396918000109 |
| format | Article |
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T. K. ; Backianathan, Selvamani ; Nayak, Sukriya</creator><creatorcontrib>Sebastian, Patricia ; Siddique, Sharief K. ; Varghese, Sunitha Susan ; Prabhu, Anne Jennifer ; Titus, V. T. K. ; Backianathan, Selvamani ; Nayak, Sukriya</creatorcontrib><description>BackgroundDermatofibrosarcoma protuberans (DFSP) is a locally aggressive intermediate malignancy.ObjectiveThe purpose of this retrospective analysis is to determine the efficacy of radiation therapy (RT) in local control of DFSP.Patients and methodsThe recurrence-free survival (RFS) for 45 patients treated for DFSP at our institution was estimated and compared between surgery alone and postoperative RT groups.ResultsAge range of the patients were in the third and fourth decades; males:females=2:1; most common site: anterior abdominal wall; tumours >5 cm in size in 75%; low grade in 77·8%; margins positive in 31·8% and <5 mm margins in 45·5%. Two-thirds of patients had at least one recurrence before presentation to our institution. RT dose was >50 Gy in 88% of patients. The patients treated with postoperative RT had poorer prognostic factors compared with surgery alone: they were males (17 versus 13 patients), and presented with high-grade tumours (5 versus 1 patients), multiple recurrences prior to presentation (25 versus 20 patients) and positive or <5 mm margins (22 versus 12 patients). Median follow-up for surgery alone group was 17 (1–152) months and for postoperative RT group, this was 54 (5–121) months. RFS at 5 years was 77·1% for surgery alone and 87·9% for postoperative RT group but was not statistically significant. The median time to recurrence was 4 years.ConclusionRT delays the time to recurrence in DFSP. RT improves the outcome of DFSP for recurrent tumours and with positive margins.</description><identifier>ISSN: 1460-3969</identifier><identifier>EISSN: 1467-1131</identifier><identifier>DOI: 10.1017/S1460396918000109</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Abdominal wall ; Age ; Background radiation ; Dermatofibrosarcoma protuberans ; Females ; Histopathology ; Males ; Malignancy ; Metastasis ; Original Article ; Patients ; Radiation ; Radiation therapy ; Statistical analysis ; Surgery ; Systematic review ; Tumors</subject><ispartof>Journal of radiotherapy in practice, 2018-12, Vol.17 (4), p.390-395</ispartof><rights>Cambridge University Press 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c269t-7caae8b475131b5b475e4b1fe0fd814715f577acfc44abbed233efd0b2eb85923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S1460396918000109/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids></links><search><creatorcontrib>Sebastian, Patricia</creatorcontrib><creatorcontrib>Siddique, Sharief K.</creatorcontrib><creatorcontrib>Varghese, Sunitha Susan</creatorcontrib><creatorcontrib>Prabhu, Anne Jennifer</creatorcontrib><creatorcontrib>Titus, V. T. K.</creatorcontrib><creatorcontrib>Backianathan, Selvamani</creatorcontrib><creatorcontrib>Nayak, Sukriya</creatorcontrib><title>Dermatofibrosarcoma protuberans – the impact of radiation therapy: a single institution series</title><title>Journal of radiotherapy in practice</title><addtitle>J Radiother Pract</addtitle><description>BackgroundDermatofibrosarcoma protuberans (DFSP) is a locally aggressive intermediate malignancy.ObjectiveThe purpose of this retrospective analysis is to determine the efficacy of radiation therapy (RT) in local control of DFSP.Patients and methodsThe recurrence-free survival (RFS) for 45 patients treated for DFSP at our institution was estimated and compared between surgery alone and postoperative RT groups.ResultsAge range of the patients were in the third and fourth decades; males:females=2:1; most common site: anterior abdominal wall; tumours >5 cm in size in 75%; low grade in 77·8%; margins positive in 31·8% and <5 mm margins in 45·5%. Two-thirds of patients had at least one recurrence before presentation to our institution. RT dose was >50 Gy in 88% of patients. The patients treated with postoperative RT had poorer prognostic factors compared with surgery alone: they were males (17 versus 13 patients), and presented with high-grade tumours (5 versus 1 patients), multiple recurrences prior to presentation (25 versus 20 patients) and positive or <5 mm margins (22 versus 12 patients). Median follow-up for surgery alone group was 17 (1–152) months and for postoperative RT group, this was 54 (5–121) months. RFS at 5 years was 77·1% for surgery alone and 87·9% for postoperative RT group but was not statistically significant. The median time to recurrence was 4 years.ConclusionRT delays the time to recurrence in DFSP. RT improves the outcome of DFSP for recurrent tumours and with positive margins.</description><subject>Abdominal wall</subject><subject>Age</subject><subject>Background radiation</subject><subject>Dermatofibrosarcoma protuberans</subject><subject>Females</subject><subject>Histopathology</subject><subject>Males</subject><subject>Malignancy</subject><subject>Metastasis</subject><subject>Original Article</subject><subject>Patients</subject><subject>Radiation</subject><subject>Radiation therapy</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Systematic review</subject><subject>Tumors</subject><issn>1460-3969</issn><issn>1467-1131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1UMtOwzAQtBBIlMIHcLPEOeB1nDrhhspTqsQBOId1YhdXzQPbOXDjH_hDvgSnrcQBcdrVzszu7BByCuwcGMiLJxAzlhazAnLGGLBij0ziSCYAKexvepaM-CE58n7FmBCCyQl5vdauwdAZq1zn0VVdg7R3XRiUdth6-v35RcObprbpsQq0M9RhbTHYrh3nDvuPS4rU23a5jqzWBxuGDeq1s9ofkwODa69PdnVKXm5vnuf3yeLx7mF-tUgqPitCIitEnSshs-hXZWOjhQKjmalzEBIyk0mJlamEQKV0zdNUm5oprlWeFTydkrPt3mj-fdA-lKtucG08WXJIeQY8phFZsGVV8VvvtCl7Zxt0HyWwcgyy_BNk1KQ7DTbK2Xqpf1f_r_oBSlZ3wg</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Sebastian, Patricia</creator><creator>Siddique, Sharief K.</creator><creator>Varghese, Sunitha Susan</creator><creator>Prabhu, Anne Jennifer</creator><creator>Titus, V. 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K.</creator><creator>Backianathan, Selvamani</creator><creator>Nayak, Sukriya</creator><general>Cambridge University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>201812</creationdate><title>Dermatofibrosarcoma protuberans – the impact of radiation therapy: a single institution series</title><author>Sebastian, Patricia ; Siddique, Sharief K. ; Varghese, Sunitha Susan ; Prabhu, Anne Jennifer ; Titus, V. T. K. ; Backianathan, Selvamani ; Nayak, Sukriya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c269t-7caae8b475131b5b475e4b1fe0fd814715f577acfc44abbed233efd0b2eb85923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abdominal wall</topic><topic>Age</topic><topic>Background radiation</topic><topic>Dermatofibrosarcoma protuberans</topic><topic>Females</topic><topic>Histopathology</topic><topic>Males</topic><topic>Malignancy</topic><topic>Metastasis</topic><topic>Original Article</topic><topic>Patients</topic><topic>Radiation</topic><topic>Radiation therapy</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>Systematic review</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sebastian, Patricia</creatorcontrib><creatorcontrib>Siddique, Sharief K.</creatorcontrib><creatorcontrib>Varghese, Sunitha Susan</creatorcontrib><creatorcontrib>Prabhu, Anne Jennifer</creatorcontrib><creatorcontrib>Titus, V. 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K.</creatorcontrib><creatorcontrib>Backianathan, Selvamani</creatorcontrib><creatorcontrib>Nayak, Sukriya</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of radiotherapy in practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sebastian, Patricia</au><au>Siddique, Sharief K.</au><au>Varghese, Sunitha Susan</au><au>Prabhu, Anne Jennifer</au><au>Titus, V. T. K.</au><au>Backianathan, Selvamani</au><au>Nayak, Sukriya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dermatofibrosarcoma protuberans – the impact of radiation therapy: a single institution series</atitle><jtitle>Journal of radiotherapy in practice</jtitle><addtitle>J Radiother Pract</addtitle><date>2018-12</date><risdate>2018</risdate><volume>17</volume><issue>4</issue><spage>390</spage><epage>395</epage><pages>390-395</pages><issn>1460-3969</issn><eissn>1467-1131</eissn><abstract>BackgroundDermatofibrosarcoma protuberans (DFSP) is a locally aggressive intermediate malignancy.ObjectiveThe purpose of this retrospective analysis is to determine the efficacy of radiation therapy (RT) in local control of DFSP.Patients and methodsThe recurrence-free survival (RFS) for 45 patients treated for DFSP at our institution was estimated and compared between surgery alone and postoperative RT groups.ResultsAge range of the patients were in the third and fourth decades; males:females=2:1; most common site: anterior abdominal wall; tumours >5 cm in size in 75%; low grade in 77·8%; margins positive in 31·8% and <5 mm margins in 45·5%. Two-thirds of patients had at least one recurrence before presentation to our institution. RT dose was >50 Gy in 88% of patients. The patients treated with postoperative RT had poorer prognostic factors compared with surgery alone: they were males (17 versus 13 patients), and presented with high-grade tumours (5 versus 1 patients), multiple recurrences prior to presentation (25 versus 20 patients) and positive or <5 mm margins (22 versus 12 patients). Median follow-up for surgery alone group was 17 (1–152) months and for postoperative RT group, this was 54 (5–121) months. RFS at 5 years was 77·1% for surgery alone and 87·9% for postoperative RT group but was not statistically significant. The median time to recurrence was 4 years.ConclusionRT delays the time to recurrence in DFSP. RT improves the outcome of DFSP for recurrent tumours and with positive margins.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><doi>10.1017/S1460396918000109</doi><tpages>6</tpages></addata></record> |
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| subjects | Abdominal wall Age Background radiation Dermatofibrosarcoma protuberans Females Histopathology Males Malignancy Metastasis Original Article Patients Radiation Radiation therapy Statistical analysis Surgery Systematic review Tumors |
| title | Dermatofibrosarcoma protuberans – the impact of radiation therapy: a single institution series |
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