Blood-derived amyloid-β protein induces Alzheimer’s disease pathologies

The amyloid-β protein (Aβ) protein plays a pivotal role in the pathogenesis of Alzheimer’s disease (AD). It is believed that Aβ deposited in the brain originates from the brain tissue itself. However, Aβ is generated in both brain and peripheral tissues. Whether circulating Aβ contributes to brain A...

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Veröffentlicht in:	Molecular psychiatry 2018-09, Vol.23 (9), p.1948-1956
Hauptverfasser:	Bu, X-L, Xiang, Y, Jin, W-S, Wang, J, Shen, L-L, Huang, Z-L, Zhang, K, Liu, Y-H, Zeng, F, Liu, J-H, Sun, H-L, Zhuang, Z-Q, Chen, S-H, Yao, X-Q, Giunta, B, Shan, Y-C, Tan, J, Chen, X-W, Dong, Z-F, Zhou, H-D, Zhou, X-F, Song, W, Wang, Y-J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - blood Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - physiology Amyloid beta-Protein Precursor - metabolism Animals Behavioral Sciences Biological Psychology Blood Brain Brain - metabolism Brain - pathology Cerebral amyloid angiopathy Cerebral Amyloid Angiopathy - metabolism Cerebral blood flow Disease Models, Animal Female Hippocampus Hippocampus - metabolism Inflammation Long-term potentiation Male Medicine Medicine & Public Health Metabolism Mice Mice, Inbred C57BL Mice, Transgenic Neurodegeneration Neurons - metabolism Neurosciences Parabiosis Parabiosis - methods Pathogenesis Pharmacotherapy Phosphorylation Plaque, Amyloid - etiology Plaque, Amyloid - metabolism Presenilin-1 - metabolism Proteins Psychiatry Rodents Senile plaques Tau protein Transgenic mice
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