Characterization of a novel sigma-2 receptor PET probe for brain imaging studies

Objectives: Sigma-2 receptor (S2R) antagonists have been reported to antagonize beta amyloid (Abeta) oligomer trafficking to neurons, thereby having a disease-modifying benefit for Alzheimer’s disease (AD) patients. Consequently, a PET radiotracer for studying the role of the S2R in AD is needed. Un...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2018-05, Vol.59, p.1635
Hauptverfasser:	Weng, Chi-Chang, Padakanti, Prashanth, Hou, Catherine, Hsieh, Chia-Ju, Lieberman, Brian, Li, Shihong, Lee, sharon, Peng, Xin, Mach, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Alzheimer's disease Animals Antagonist drugs Blood-brain barrier Brain Coinjection Dosage In vivo methods and tests Injection Macaca mulatta Mathematical analysis Medical imaging Mice Muscles Neostriatum Neuroimaging Neurons Organ weight Pentazocine Positron emission Positron emission tomography Proteins Radioactive tracers Receptors Selectivity Thalamus Tomography β-Amyloid
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