Radiosynthesis and evaluation of a high affinity GSK3 ligand [^sup 11^C]CMP

Objectives: Glycogen synthase kinase-3 (GSK3) plays significant role as a signaling mediator and it deals with more than 100 substrates in most cells. Dysfunction of GSK3 is implicated in the etiology of a variety of psychiatric disorders, neurological disorders, inflammatory diseases and cancer. No...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2018-05, Vol.59, p.1029
Hauptverfasser:	Prabhakaran, Jaya, Kumar, Dileep, Sattiraju, Anirudh, Ramanathan, Gayathri, Mintz, Akiva, Mann, J John, Solingapuram Sai, Kiran Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Alkylation Binding Blood-brain barrier Brain diseases Cancer Cell culture Change detection Chemical synthesis Computed tomography Cyclosporins Demethylation Disorders Efflux Etiology Evaluation Glioblastoma Glioblastoma cells Glycogen Glycogen synthase kinase 3 Inflammatory diseases Injection Kinases Ligands Medical imaging Mental disorders Mice Neuroimaging Neurological diseases Penetration Positron emission Positron emission tomography Purity Radioactive tracers Radioactivity Radiochemistry Radiolabelling Radiology Sodium hydroxide Substrates Tomography
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