Macro-micron-nano-featured surface topography of Ti-6Al-4V alloy for biomedical applications
One of the critical issues in the development of novel metallic biomaterials is the design and fabrication of metallic scaffolds and implants with hierarchical structures mimicking human bones. In this work, selective laser melting (SLM) and electrochemical anodization were applied to fabricate dens...
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| Veröffentlicht in: | Rare metals 2018-12, Vol.37 (12), p.1055-1063 |
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| creator | Zhao, Da-Peng Tang, Jin-Cheng Nie, He-Min Zhang, Yuan Chen, Yu-Kai Zhang, Xu Li, Hui-Xing Yan, Ming |
| description | One of the critical issues in the development of novel metallic biomaterials is the design and fabrication of metallic scaffolds and implants with hierarchical structures mimicking human bones. In this work, selective laser melting (SLM) and electrochemical anodization were applied to fabricate dense Ti-6Al-4V components with macro-micron-nanoscale hierarchical surfaces. Scanning electron microscopy (SEM), 3D laser scanning microscopy (3D LSM), contact angle video system, fluorescence microscopy and spectrophotometer were used to investigate the properties of the samples. The results reveal that the SLMed post-anodization (SLM-TNT) exhibits enhanced or at least comparable wettability, protein adsorption and biological response of mesenchymal stem cells (MSCs) in comparison with the three reference configurations, i.e., the polished Ti-6Al-4V (PO-Ti64), the SLMed Ti-6Al-4V (SLM-Ti64) and the polished Ti-6Al-4V post-anodization (PO-TNT). The improved cytocompatibility of the samples after SLM and anodization should be mainly attributed to the nanoscale tubular features, while the macro-micron-scale structures only lead to slight preference for cell attachment. |
| doi_str_mv | 10.1007/s12598-018-1150-7 |
| format | Article |
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In this work, selective laser melting (SLM) and electrochemical anodization were applied to fabricate dense Ti-6Al-4V components with macro-micron-nanoscale hierarchical surfaces. Scanning electron microscopy (SEM), 3D laser scanning microscopy (3D LSM), contact angle video system, fluorescence microscopy and spectrophotometer were used to investigate the properties of the samples. The results reveal that the SLMed post-anodization (SLM-TNT) exhibits enhanced or at least comparable wettability, protein adsorption and biological response of mesenchymal stem cells (MSCs) in comparison with the three reference configurations, i.e., the polished Ti-6Al-4V (PO-Ti64), the SLMed Ti-6Al-4V (SLM-Ti64) and the polished Ti-6Al-4V post-anodization (PO-TNT). The improved cytocompatibility of the samples after SLM and anodization should be mainly attributed to the nanoscale tubular features, while the macro-micron-scale structures only lead to slight preference for cell attachment.</description><identifier>ISSN: 1001-0521</identifier><identifier>EISSN: 1867-7185</identifier><identifier>DOI: 10.1007/s12598-018-1150-7</identifier><language>eng</language><publisher>Beijing: Nonferrous Metals Society of China</publisher><subject>Anodizing ; Biocompatibility ; Biomaterials ; Biomedical materials ; Bones ; Chemistry and Materials Science ; Contact angle ; Energy ; Fluorescence ; Laser beam melting ; Materials Engineering ; Materials Science ; Metallic Materials ; Microscopy ; Nanoscale Science and Technology ; Physical Chemistry ; Protein adsorption ; Proteins ; Scanning electron microscopy ; Scanning microscopy ; Scanning transmission electron microscopy ; Stem cells ; Structural hierarchy ; Surgical implants ; Titanium base alloys ; Wettability</subject><ispartof>Rare metals, 2018-12, Vol.37 (12), p.1055-1063</ispartof><rights>The Nonferrous Metals Society of China and Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Rare Metals is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-ec4d56e960901c99ad263e4232b29bba834bb031afbc9c5dbd1003f4524ea933</citedby><cites>FETCH-LOGICAL-c316t-ec4d56e960901c99ad263e4232b29bba834bb031afbc9c5dbd1003f4524ea933</cites><orcidid>0000-0001-6777-7760</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12598-018-1150-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12598-018-1150-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids></links><search><creatorcontrib>Zhao, Da-Peng</creatorcontrib><creatorcontrib>Tang, Jin-Cheng</creatorcontrib><creatorcontrib>Nie, He-Min</creatorcontrib><creatorcontrib>Zhang, Yuan</creatorcontrib><creatorcontrib>Chen, Yu-Kai</creatorcontrib><creatorcontrib>Zhang, Xu</creatorcontrib><creatorcontrib>Li, Hui-Xing</creatorcontrib><creatorcontrib>Yan, Ming</creatorcontrib><title>Macro-micron-nano-featured surface topography of Ti-6Al-4V alloy for biomedical applications</title><title>Rare metals</title><addtitle>Rare Met</addtitle><description>One of the critical issues in the development of novel metallic biomaterials is the design and fabrication of metallic scaffolds and implants with hierarchical structures mimicking human bones. In this work, selective laser melting (SLM) and electrochemical anodization were applied to fabricate dense Ti-6Al-4V components with macro-micron-nanoscale hierarchical surfaces. Scanning electron microscopy (SEM), 3D laser scanning microscopy (3D LSM), contact angle video system, fluorescence microscopy and spectrophotometer were used to investigate the properties of the samples. The results reveal that the SLMed post-anodization (SLM-TNT) exhibits enhanced or at least comparable wettability, protein adsorption and biological response of mesenchymal stem cells (MSCs) in comparison with the three reference configurations, i.e., the polished Ti-6Al-4V (PO-Ti64), the SLMed Ti-6Al-4V (SLM-Ti64) and the polished Ti-6Al-4V post-anodization (PO-TNT). The improved cytocompatibility of the samples after SLM and anodization should be mainly attributed to the nanoscale tubular features, while the macro-micron-scale structures only lead to slight preference for cell attachment.</description><subject>Anodizing</subject><subject>Biocompatibility</subject><subject>Biomaterials</subject><subject>Biomedical materials</subject><subject>Bones</subject><subject>Chemistry and Materials Science</subject><subject>Contact angle</subject><subject>Energy</subject><subject>Fluorescence</subject><subject>Laser beam melting</subject><subject>Materials Engineering</subject><subject>Materials Science</subject><subject>Metallic Materials</subject><subject>Microscopy</subject><subject>Nanoscale Science and Technology</subject><subject>Physical Chemistry</subject><subject>Protein adsorption</subject><subject>Proteins</subject><subject>Scanning electron microscopy</subject><subject>Scanning microscopy</subject><subject>Scanning transmission electron microscopy</subject><subject>Stem cells</subject><subject>Structural hierarchy</subject><subject>Surgical implants</subject><subject>Titanium base alloys</subject><subject>Wettability</subject><issn>1001-0521</issn><issn>1867-7185</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kEtPwzAQhC0EEqXwA7hZ4mzw-pHEx6riJRVxqTghWY5jl1RpHOzk0H-PqyBx4rK7h5lZzYfQLdB7oLR8SMCkqgiFigBISsoztICqKEkJlTzPN6VAqGRwia5S2lMqRFHQBfp8MzYGcmjz7Elv-kC8M-MUXYPTFL2xDo9hCLtohq8jDh5vW1KsOiI-sOm6cMQ-RFy34eCa1poOm2Ho8jG2oU_X6MKbLrmb371E26fH7fqFbN6fX9erDbEcipE4KxpZOFVQRcEqZRpWcCcYZzVTdW0qLuqacjC-tsrKpm5yG-6FZMIZxfkS3c2xQwzfk0uj3ocp9vmjZsBBCl4plVUwq3LTlKLzeojtwcSjBqpPDPXMUGeG-sRQl9nDZk_K2n7n4l_y_6YffO90Tw</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Zhao, Da-Peng</creator><creator>Tang, Jin-Cheng</creator><creator>Nie, He-Min</creator><creator>Zhang, Yuan</creator><creator>Chen, Yu-Kai</creator><creator>Zhang, Xu</creator><creator>Li, Hui-Xing</creator><creator>Yan, Ming</creator><general>Nonferrous Metals Society of China</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0001-6777-7760</orcidid></search><sort><creationdate>20181201</creationdate><title>Macro-micron-nano-featured surface topography of Ti-6Al-4V alloy for biomedical applications</title><author>Zhao, Da-Peng ; Tang, Jin-Cheng ; Nie, He-Min ; Zhang, Yuan ; Chen, Yu-Kai ; Zhang, Xu ; Li, Hui-Xing ; Yan, Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-ec4d56e960901c99ad263e4232b29bba834bb031afbc9c5dbd1003f4524ea933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anodizing</topic><topic>Biocompatibility</topic><topic>Biomaterials</topic><topic>Biomedical materials</topic><topic>Bones</topic><topic>Chemistry and Materials Science</topic><topic>Contact angle</topic><topic>Energy</topic><topic>Fluorescence</topic><topic>Laser beam melting</topic><topic>Materials Engineering</topic><topic>Materials Science</topic><topic>Metallic Materials</topic><topic>Microscopy</topic><topic>Nanoscale Science and Technology</topic><topic>Physical Chemistry</topic><topic>Protein adsorption</topic><topic>Proteins</topic><topic>Scanning electron microscopy</topic><topic>Scanning microscopy</topic><topic>Scanning transmission electron microscopy</topic><topic>Stem cells</topic><topic>Structural hierarchy</topic><topic>Surgical implants</topic><topic>Titanium base alloys</topic><topic>Wettability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Da-Peng</creatorcontrib><creatorcontrib>Tang, Jin-Cheng</creatorcontrib><creatorcontrib>Nie, He-Min</creatorcontrib><creatorcontrib>Zhang, Yuan</creatorcontrib><creatorcontrib>Chen, Yu-Kai</creatorcontrib><creatorcontrib>Zhang, Xu</creatorcontrib><creatorcontrib>Li, Hui-Xing</creatorcontrib><creatorcontrib>Yan, Ming</creatorcontrib><collection>CrossRef</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Rare metals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Da-Peng</au><au>Tang, Jin-Cheng</au><au>Nie, He-Min</au><au>Zhang, Yuan</au><au>Chen, Yu-Kai</au><au>Zhang, Xu</au><au>Li, Hui-Xing</au><au>Yan, Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Macro-micron-nano-featured surface topography of Ti-6Al-4V alloy for biomedical applications</atitle><jtitle>Rare metals</jtitle><stitle>Rare Met</stitle><date>2018-12-01</date><risdate>2018</risdate><volume>37</volume><issue>12</issue><spage>1055</spage><epage>1063</epage><pages>1055-1063</pages><issn>1001-0521</issn><eissn>1867-7185</eissn><abstract>One of the critical issues in the development of novel metallic biomaterials is the design and fabrication of metallic scaffolds and implants with hierarchical structures mimicking human bones. In this work, selective laser melting (SLM) and electrochemical anodization were applied to fabricate dense Ti-6Al-4V components with macro-micron-nanoscale hierarchical surfaces. Scanning electron microscopy (SEM), 3D laser scanning microscopy (3D LSM), contact angle video system, fluorescence microscopy and spectrophotometer were used to investigate the properties of the samples. The results reveal that the SLMed post-anodization (SLM-TNT) exhibits enhanced or at least comparable wettability, protein adsorption and biological response of mesenchymal stem cells (MSCs) in comparison with the three reference configurations, i.e., the polished Ti-6Al-4V (PO-Ti64), the SLMed Ti-6Al-4V (SLM-Ti64) and the polished Ti-6Al-4V post-anodization (PO-TNT). The improved cytocompatibility of the samples after SLM and anodization should be mainly attributed to the nanoscale tubular features, while the macro-micron-scale structures only lead to slight preference for cell attachment.</abstract><cop>Beijing</cop><pub>Nonferrous Metals Society of China</pub><doi>10.1007/s12598-018-1150-7</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6777-7760</orcidid></addata></record> |
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| subjects | Anodizing Biocompatibility Biomaterials Biomedical materials Bones Chemistry and Materials Science Contact angle Energy Fluorescence Laser beam melting Materials Engineering Materials Science Metallic Materials Microscopy Nanoscale Science and Technology Physical Chemistry Protein adsorption Proteins Scanning electron microscopy Scanning microscopy Scanning transmission electron microscopy Stem cells Structural hierarchy Surgical implants Titanium base alloys Wettability |
| title | Macro-micron-nano-featured surface topography of Ti-6Al-4V alloy for biomedical applications |
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