Potential immunomodulatory and antioxidant effects of walnut Juglans regia vegetable oil against lead‐mediated hepatic damage and their interaction with lipase activity in rats
Environmental pollutants, particularly lead, pose a serious threat to human and animal health that causes disturbances of several functions, including hepatotoxicity. Therefore, the search for a new treatment that could safely and effectively block or reverse liver injuries remains a challenge. This...
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| Veröffentlicht in: | Environmental toxicology 2018-12, Vol.33 (12), p.1261-1271 |
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| creator | Soussi, Ahlem Gargouri, Manel El Feki, Abdelfattah |
| description | Environmental pollutants, particularly lead, pose a serious threat to human and animal health that causes disturbances of several functions, including hepatotoxicity. Therefore, the search for a new treatment that could safely and effectively block or reverse liver injuries remains a challenge. This study was carried out to investigate the protective efficacy of Juglans regia vegetable oil (JRVO) against the hepatotoxicity induced by lead. To achieve this aim, adults male rats were treated for 10 days with Pb (0.344 g/kg bw) associated or not with JRVO (0.9 g/kg bw). The rats intoxicated by lead exhibited oxidative stress determined by TBARS, protein carbonyls, liver tumor necrosis factor‐α (TNF‐α), caspase‐3, and antioxidant status: SOD, CAT, GPx, and GSH. Administration of lead increased the levels of plasma hepatic markers (AST, ALT, LDH) and bilirubin, the lipid profiles (total cholesterol, triglycerides, VLDL‐Ch, LDL‐Ch levels, TBARS, NOx, and PCO), the plasmatic lipase activity and the inflammatory markers, while the plasmatic ALP decreased. Coadministration of JRVO restored all the hepatic markers, the lipid profiles and the antioxidants to near‐normal values and lowered the plasmatic lipase activity as well as the elevated thiobarbituric acid reactive substances. Hepatic histological studies confirmed the beneficial role of JRVO through the amelioration of all biochemical parameters. Our results suggest that Juglans regia vegetable oil contains promising substances to counteract the lead intoxication and may be efficient in the prevention of hepatotoxicity complications. |
| doi_str_mv | 10.1002/tox.22634 |
| format | Article |
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Therefore, the search for a new treatment that could safely and effectively block or reverse liver injuries remains a challenge. This study was carried out to investigate the protective efficacy of Juglans regia vegetable oil (JRVO) against the hepatotoxicity induced by lead. To achieve this aim, adults male rats were treated for 10 days with Pb (0.344 g/kg bw) associated or not with JRVO (0.9 g/kg bw). The rats intoxicated by lead exhibited oxidative stress determined by TBARS, protein carbonyls, liver tumor necrosis factor‐α (TNF‐α), caspase‐3, and antioxidant status: SOD, CAT, GPx, and GSH. Administration of lead increased the levels of plasma hepatic markers (AST, ALT, LDH) and bilirubin, the lipid profiles (total cholesterol, triglycerides, VLDL‐Ch, LDL‐Ch levels, TBARS, NOx, and PCO), the plasmatic lipase activity and the inflammatory markers, while the plasmatic ALP decreased. Coadministration of JRVO restored all the hepatic markers, the lipid profiles and the antioxidants to near‐normal values and lowered the plasmatic lipase activity as well as the elevated thiobarbituric acid reactive substances. Hepatic histological studies confirmed the beneficial role of JRVO through the amelioration of all biochemical parameters. Our results suggest that Juglans regia vegetable oil contains promising substances to counteract the lead intoxication and may be efficient in the prevention of hepatotoxicity complications.</description><identifier>ISSN: 1520-4081</identifier><identifier>EISSN: 1522-7278</identifier><identifier>DOI: 10.1002/tox.22634</identifier><identifier>PMID: 30251767</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adults ; Animal health ; Animals ; Antioxidants ; Antioxidants - pharmacology ; Bilirubin ; Carbonyl compounds ; Carbonyls ; Caspase ; caspase‐3 ; Chemical and Drug Induced Liver Injury - prevention & control ; Cholesterol ; GC‐Ms ; Hepatotoxicity ; Immunomodulation ; Immunomodulation - drug effects ; Immunomodulators ; Inflammation ; Intoxication ; Juglans - chemistry ; Juglans regia ; Lead ; Lead - toxicity ; Lipase ; Lipase - metabolism ; Lipids ; Lipoproteins (very low density) ; Liver ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Liver cancer ; Low density lipoprotein ; Male ; Markers ; Necrosis ; Neoplasms ; Nitrogen compounds ; Oil ; Oils & fats ; Oxidative stress ; Oxidative Stress - drug effects ; Oxides ; Plant Extracts - pharmacology ; Plant Oils - pharmacology ; Pollutants ; Profiles ; Proteins ; Rats ; Rats, Wistar ; Rodents ; Thiobarbituric acid ; Thiobarbituric Acid Reactive Substances - metabolism ; TNF‐α ; Triglycerides ; Tumor necrosis factor ; Tumor necrosis factor-TNF ; vegetable oil ; Vegetable oils ; Vegetables ; walnut ; Walnuts</subject><ispartof>Environmental toxicology, 2018-12, Vol.33 (12), p.1261-1271</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3534-d019bdddd72250baba2b30d97c717c778a8a7a5063dbf022900bb95658344a93</citedby><cites>FETCH-LOGICAL-c3534-d019bdddd72250baba2b30d97c717c778a8a7a5063dbf022900bb95658344a93</cites><orcidid>0000-0002-1803-3308</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Ftox.22634$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Ftox.22634$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30251767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soussi, Ahlem</creatorcontrib><creatorcontrib>Gargouri, Manel</creatorcontrib><creatorcontrib>El Feki, Abdelfattah</creatorcontrib><title>Potential immunomodulatory and antioxidant effects of walnut Juglans regia vegetable oil against lead‐mediated hepatic damage and their interaction with lipase activity in rats</title><title>Environmental toxicology</title><addtitle>Environ Toxicol</addtitle><description>Environmental pollutants, particularly lead, pose a serious threat to human and animal health that causes disturbances of several functions, including hepatotoxicity. Therefore, the search for a new treatment that could safely and effectively block or reverse liver injuries remains a challenge. This study was carried out to investigate the protective efficacy of Juglans regia vegetable oil (JRVO) against the hepatotoxicity induced by lead. To achieve this aim, adults male rats were treated for 10 days with Pb (0.344 g/kg bw) associated or not with JRVO (0.9 g/kg bw). The rats intoxicated by lead exhibited oxidative stress determined by TBARS, protein carbonyls, liver tumor necrosis factor‐α (TNF‐α), caspase‐3, and antioxidant status: SOD, CAT, GPx, and GSH. Administration of lead increased the levels of plasma hepatic markers (AST, ALT, LDH) and bilirubin, the lipid profiles (total cholesterol, triglycerides, VLDL‐Ch, LDL‐Ch levels, TBARS, NOx, and PCO), the plasmatic lipase activity and the inflammatory markers, while the plasmatic ALP decreased. Coadministration of JRVO restored all the hepatic markers, the lipid profiles and the antioxidants to near‐normal values and lowered the plasmatic lipase activity as well as the elevated thiobarbituric acid reactive substances. Hepatic histological studies confirmed the beneficial role of JRVO through the amelioration of all biochemical parameters. Our results suggest that Juglans regia vegetable oil contains promising substances to counteract the lead intoxication and may be efficient in the prevention of hepatotoxicity complications.</description><subject>Adults</subject><subject>Animal health</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Bilirubin</subject><subject>Carbonyl compounds</subject><subject>Carbonyls</subject><subject>Caspase</subject><subject>caspase‐3</subject><subject>Chemical and Drug Induced Liver Injury - prevention & control</subject><subject>Cholesterol</subject><subject>GC‐Ms</subject><subject>Hepatotoxicity</subject><subject>Immunomodulation</subject><subject>Immunomodulation - drug effects</subject><subject>Immunomodulators</subject><subject>Inflammation</subject><subject>Intoxication</subject><subject>Juglans - chemistry</subject><subject>Juglans regia</subject><subject>Lead</subject><subject>Lead - toxicity</subject><subject>Lipase</subject><subject>Lipase - metabolism</subject><subject>Lipids</subject><subject>Lipoproteins (very low density)</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver cancer</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Markers</subject><subject>Necrosis</subject><subject>Neoplasms</subject><subject>Nitrogen compounds</subject><subject>Oil</subject><subject>Oils & fats</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxides</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Oils - pharmacology</subject><subject>Pollutants</subject><subject>Profiles</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Thiobarbituric acid</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>TNF‐α</subject><subject>Triglycerides</subject><subject>Tumor necrosis factor</subject><subject>Tumor necrosis factor-TNF</subject><subject>vegetable oil</subject><subject>Vegetable oils</subject><subject>Vegetables</subject><subject>walnut</subject><subject>Walnuts</subject><issn>1520-4081</issn><issn>1522-7278</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9u1DAQxi1ERUvhwAsgS5w4pPWfOE6OqIJSVKkc9sAtGsdO1pVjL7bT7d54hD4Lj8ST1OwWbh1pNKPRT98nzYfQO0rOKCHsPIf7M8YaXr9AJ1QwVkkm25f7nVQ1aekxep3SLSGka0TzCh1zwgSVjTxBv7-HbHy24LCd58WHOejFQQ5xh8Hr0tmGe6vLxGYczZATDiPegvNLxt-WyYFPOJrJAr4zk8mgnMHBOgwTWJ8ydgb0n18Ps9EWstF4bTaQ7YA1zDCZvUleGxux9dlEGIqfx1ub19jZDaRClNOdzbsC4Ag5vUFHI7hk3j7NU7T68nl18bW6vrm8uvh0XQ1c8LrShHZKl5KMCaJAAVOc6E4OkpaWLbQgQZCGazUSxjpClOpEI1pe19DxU_ThILuJ4ediUu5vwxJ9cewZ5ZQWD0EK9fFADTGkFM3Yb6KdIe56Svq_4fQlnH4fTmHfPykuqrzjP_kvjQKcH4CtdWb3vFK_uvlxkHwESzmeag</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Soussi, Ahlem</creator><creator>Gargouri, Manel</creator><creator>El Feki, Abdelfattah</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7ST</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>K9.</scope><scope>L.G</scope><scope>M7N</scope><scope>SOI</scope><orcidid>https://orcid.org/0000-0002-1803-3308</orcidid></search><sort><creationdate>201812</creationdate><title>Potential immunomodulatory and antioxidant effects of walnut Juglans regia vegetable oil against lead‐mediated hepatic damage and their interaction with lipase activity in rats</title><author>Soussi, Ahlem ; Gargouri, Manel ; El Feki, Abdelfattah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3534-d019bdddd72250baba2b30d97c717c778a8a7a5063dbf022900bb95658344a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adults</topic><topic>Animal health</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Bilirubin</topic><topic>Carbonyl compounds</topic><topic>Carbonyls</topic><topic>Caspase</topic><topic>caspase‐3</topic><topic>Chemical and Drug Induced Liver Injury - prevention & control</topic><topic>Cholesterol</topic><topic>GC‐Ms</topic><topic>Hepatotoxicity</topic><topic>Immunomodulation</topic><topic>Immunomodulation - drug effects</topic><topic>Immunomodulators</topic><topic>Inflammation</topic><topic>Intoxication</topic><topic>Juglans - chemistry</topic><topic>Juglans regia</topic><topic>Lead</topic><topic>Lead - toxicity</topic><topic>Lipase</topic><topic>Lipase - metabolism</topic><topic>Lipids</topic><topic>Lipoproteins (very low density)</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver cancer</topic><topic>Low density lipoprotein</topic><topic>Male</topic><topic>Markers</topic><topic>Necrosis</topic><topic>Neoplasms</topic><topic>Nitrogen compounds</topic><topic>Oil</topic><topic>Oils & fats</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxides</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Oils - pharmacology</topic><topic>Pollutants</topic><topic>Profiles</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Thiobarbituric acid</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>TNF‐α</topic><topic>Triglycerides</topic><topic>Tumor necrosis factor</topic><topic>Tumor necrosis factor-TNF</topic><topic>vegetable oil</topic><topic>Vegetable oils</topic><topic>Vegetables</topic><topic>walnut</topic><topic>Walnuts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soussi, Ahlem</creatorcontrib><creatorcontrib>Gargouri, Manel</creatorcontrib><creatorcontrib>El Feki, Abdelfattah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>Environment Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Environment Abstracts</collection><jtitle>Environmental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soussi, Ahlem</au><au>Gargouri, Manel</au><au>El Feki, Abdelfattah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential immunomodulatory and antioxidant effects of walnut Juglans regia vegetable oil against lead‐mediated hepatic damage and their interaction with lipase activity in rats</atitle><jtitle>Environmental toxicology</jtitle><addtitle>Environ Toxicol</addtitle><date>2018-12</date><risdate>2018</risdate><volume>33</volume><issue>12</issue><spage>1261</spage><epage>1271</epage><pages>1261-1271</pages><issn>1520-4081</issn><eissn>1522-7278</eissn><abstract>Environmental pollutants, particularly lead, pose a serious threat to human and animal health that causes disturbances of several functions, including hepatotoxicity. Therefore, the search for a new treatment that could safely and effectively block or reverse liver injuries remains a challenge. This study was carried out to investigate the protective efficacy of Juglans regia vegetable oil (JRVO) against the hepatotoxicity induced by lead. To achieve this aim, adults male rats were treated for 10 days with Pb (0.344 g/kg bw) associated or not with JRVO (0.9 g/kg bw). The rats intoxicated by lead exhibited oxidative stress determined by TBARS, protein carbonyls, liver tumor necrosis factor‐α (TNF‐α), caspase‐3, and antioxidant status: SOD, CAT, GPx, and GSH. Administration of lead increased the levels of plasma hepatic markers (AST, ALT, LDH) and bilirubin, the lipid profiles (total cholesterol, triglycerides, VLDL‐Ch, LDL‐Ch levels, TBARS, NOx, and PCO), the plasmatic lipase activity and the inflammatory markers, while the plasmatic ALP decreased. Coadministration of JRVO restored all the hepatic markers, the lipid profiles and the antioxidants to near‐normal values and lowered the plasmatic lipase activity as well as the elevated thiobarbituric acid reactive substances. Hepatic histological studies confirmed the beneficial role of JRVO through the amelioration of all biochemical parameters. Our results suggest that Juglans regia vegetable oil contains promising substances to counteract the lead intoxication and may be efficient in the prevention of hepatotoxicity complications.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>30251767</pmid><doi>10.1002/tox.22634</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-1803-3308</orcidid></addata></record> |
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| ispartof | Environmental toxicology, 2018-12, Vol.33 (12), p.1261-1271 |
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| subjects | Adults Animal health Animals Antioxidants Antioxidants - pharmacology Bilirubin Carbonyl compounds Carbonyls Caspase caspase‐3 Chemical and Drug Induced Liver Injury - prevention & control Cholesterol GC‐Ms Hepatotoxicity Immunomodulation Immunomodulation - drug effects Immunomodulators Inflammation Intoxication Juglans - chemistry Juglans regia Lead Lead - toxicity Lipase Lipase - metabolism Lipids Lipoproteins (very low density) Liver Liver - drug effects Liver - metabolism Liver - pathology Liver cancer Low density lipoprotein Male Markers Necrosis Neoplasms Nitrogen compounds Oil Oils & fats Oxidative stress Oxidative Stress - drug effects Oxides Plant Extracts - pharmacology Plant Oils - pharmacology Pollutants Profiles Proteins Rats Rats, Wistar Rodents Thiobarbituric acid Thiobarbituric Acid Reactive Substances - metabolism TNF‐α Triglycerides Tumor necrosis factor Tumor necrosis factor-TNF vegetable oil Vegetable oils Vegetables walnut Walnuts |
| title | Potential immunomodulatory and antioxidant effects of walnut Juglans regia vegetable oil against lead‐mediated hepatic damage and their interaction with lipase activity in rats |
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