A New Flavone and Cytotoxic Constituents of Nicotiana tabacum
A new flavone, 8-formyl-7-hydroxy-6,4′-dimethoxyflavone ( 1 ), has been isolated from the leaves of Nicotiana tabacum, together with five known compounds, 8-formyl-4′-hydroxy-6,7-dimethoxyflavone ( 2 ), quercetin ( 3 ), (2R,3R)-3,5-dihydroxy-7-methoxyflavanone ( 4 ), kaempferol ( 5 ), and rutin ( 6...
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| Veröffentlicht in: | Chemistry of natural compounds 2018-11, Vol.54 (6), p.1044-1047 |
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| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A new flavone, 8-formyl-7-hydroxy-6,4′-dimethoxyflavone (
1
), has been isolated from the leaves of Nicotiana tabacum, together with five known compounds, 8-formyl-4′-hydroxy-6,7-dimethoxyflavone (
2
), quercetin (
3
), (2R,3R)-3,5-dihydroxy-7-methoxyflavanone (
4
), kaempferol (
5
), and rutin (
6
). The structure of the new compound
1
was determined through spectroscopic and MS analyses. Among the isolates, 8-formyl-7-hydroxy-6,4′-dimethoxyflavone (
1
) and 8-formyl-4′-hydroxy-6,7-dimethoxyflavone (
2
) exhibited cytotoxicities, with IC50 values of 2.24 ± 0.32 and 3.40 ± 0.21 μg/mL, respectively, against CCRF-CEM and P388D1 cell lines. |
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| ISSN: | 0009-3130 1573-8388 |
| DOI: | 10.1007/s10600-018-2551-4 |