Assessment of a guideline-based heart substructures delineation in left-sided breast cancer patients undergoing adjuvant radiotherapy
Background and purposeIn our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014, NCT2236806), assessing preclinical heart damage with heart speckle-tracking ultrasound. To develop a dose constraint related to...
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| Veröffentlicht in: | Strahlentherapie und Onkologie 2019-01, Vol.195 (1), p.43-51 |
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| creator | Francolini, Giulio Desideri, Isacco Meattini, Icro Becherini, Carlotta Terziani, Francesca Olmetto, Emanuela Camilla Delli Paoli Donato Pezzulla Loi, Mauro Bonomo, Pierluigi Greto, Daniela Calusi, Silvia Casati, Marta Pallotta, Stefania Livi, Lorenzo |
| description | Background and purposeIn our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014, NCT2236806), assessing preclinical heart damage with heart speckle-tracking ultrasound. To develop a dose constraint related to subclinical heart damage, a reliable delineation of heart substructures based on a pre-existing guideline was made.Patients and methodsHeart substructures of 16 left-sided breast cancer patients included in the SAFE protocol were delineated by five operators. For each substructure, a multi-contour delineation based on a majority vote algorithm (MCD) was created. A consensus-based delineation (CBD) was developed by an independent team of two blinded operators. Dice similarity coefficients (DSC) between volumes delineated by different operators and the MCD were collected and reported, as well as DSC between CBD and MCD.ResultsMean DSCs between heart chambers delineated by each operator and the corresponding MCDs ranged between 0.78 and 0.96. Mean DSC between substructures delineated by all single operators and the corresponding MCD ranged between 0.84 and 0.94. Mean DSC between CBD and the corresponding MCD ranged from 0.89 to 0.97.ConclusionResults showed low inter-observer variability of heart substructure delineation. This constitutes an external validation of the contouring atlas used, allowing a reliable dosimetric assessment of these volumes within the SAFE-2014 trial. |
| doi_str_mv | 10.1007/s00066-018-1388-x |
| format | Article |
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To develop a dose constraint related to subclinical heart damage, a reliable delineation of heart substructures based on a pre-existing guideline was made.Patients and methodsHeart substructures of 16 left-sided breast cancer patients included in the SAFE protocol were delineated by five operators. For each substructure, a multi-contour delineation based on a majority vote algorithm (MCD) was created. A consensus-based delineation (CBD) was developed by an independent team of two blinded operators. Dice similarity coefficients (DSC) between volumes delineated by different operators and the MCD were collected and reported, as well as DSC between CBD and MCD.ResultsMean DSCs between heart chambers delineated by each operator and the corresponding MCDs ranged between 0.78 and 0.96. Mean DSC between substructures delineated by all single operators and the corresponding MCD ranged between 0.84 and 0.94. Mean DSC between CBD and the corresponding MCD ranged from 0.89 to 0.97.ConclusionResults showed low inter-observer variability of heart substructure delineation. This constitutes an external validation of the contouring atlas used, allowing a reliable dosimetric assessment of these volumes within the SAFE-2014 trial.</description><identifier>ISSN: 0179-7158</identifier><identifier>EISSN: 1439-099X</identifier><identifier>DOI: 10.1007/s00066-018-1388-x</identifier><language>eng</language><publisher>Heidelberg: Springer Nature B.V</publisher><subject>Algorithms ; Breast cancer ; Cancer ; Contouring ; Damage assessment ; Delineation ; Health risk assessment ; Heart ; Immunotherapy ; Monoclonal antibodies ; Operators ; Patients ; Radiation therapy ; Similarity ; Substructures ; Targeted cancer therapy ; Tracking</subject><ispartof>Strahlentherapie und Onkologie, 2019-01, Vol.195 (1), p.43-51</ispartof><rights>Strahlentherapie und Onkologie is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c767-f61556a085527261aae9b91a7b91d345e0d49965cb9ba4071edfafaf5434733</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Francolini, Giulio</creatorcontrib><creatorcontrib>Desideri, Isacco</creatorcontrib><creatorcontrib>Meattini, Icro</creatorcontrib><creatorcontrib>Becherini, Carlotta</creatorcontrib><creatorcontrib>Terziani, Francesca</creatorcontrib><creatorcontrib>Olmetto, Emanuela</creatorcontrib><creatorcontrib>Camilla Delli Paoli</creatorcontrib><creatorcontrib>Donato Pezzulla</creatorcontrib><creatorcontrib>Loi, Mauro</creatorcontrib><creatorcontrib>Bonomo, Pierluigi</creatorcontrib><creatorcontrib>Greto, Daniela</creatorcontrib><creatorcontrib>Calusi, Silvia</creatorcontrib><creatorcontrib>Casati, Marta</creatorcontrib><creatorcontrib>Pallotta, Stefania</creatorcontrib><creatorcontrib>Livi, Lorenzo</creatorcontrib><title>Assessment of a guideline-based heart substructures delineation in left-sided breast cancer patients undergoing adjuvant radiotherapy</title><title>Strahlentherapie und Onkologie</title><description>Background and purposeIn our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014, NCT2236806), assessing preclinical heart damage with heart speckle-tracking ultrasound. To develop a dose constraint related to subclinical heart damage, a reliable delineation of heart substructures based on a pre-existing guideline was made.Patients and methodsHeart substructures of 16 left-sided breast cancer patients included in the SAFE protocol were delineated by five operators. For each substructure, a multi-contour delineation based on a majority vote algorithm (MCD) was created. A consensus-based delineation (CBD) was developed by an independent team of two blinded operators. Dice similarity coefficients (DSC) between volumes delineated by different operators and the MCD were collected and reported, as well as DSC between CBD and MCD.ResultsMean DSCs between heart chambers delineated by each operator and the corresponding MCDs ranged between 0.78 and 0.96. Mean DSC between substructures delineated by all single operators and the corresponding MCD ranged between 0.84 and 0.94. Mean DSC between CBD and the corresponding MCD ranged from 0.89 to 0.97.ConclusionResults showed low inter-observer variability of heart substructure delineation. This constitutes an external validation of the contouring atlas used, allowing a reliable dosimetric assessment of these volumes within the SAFE-2014 trial.</description><subject>Algorithms</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Contouring</subject><subject>Damage assessment</subject><subject>Delineation</subject><subject>Health risk assessment</subject><subject>Heart</subject><subject>Immunotherapy</subject><subject>Monoclonal antibodies</subject><subject>Operators</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Similarity</subject><subject>Substructures</subject><subject>Targeted cancer therapy</subject><subject>Tracking</subject><issn>0179-7158</issn><issn>1439-099X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNotjc1KAzEUhYMoWKsP4C7gOppM_ibLUvyDgiAu3JU7kzvtlJqpuRnRB_C9HagcOGfznXMYu1byVknp70hK6ZyQqhZK17X4PmEzZXQQMoT3UzaTygfhla3P2QXRTkrlTDAz9rsgQqIPTIUPHQe-GfuI-z6haIAw8i1CLpzGhkoe2zJmJH4EoPRD4n3ie-yKoKkWeZMRqPAWUouZHyZkGiY-poh5M_RpwyHuxi-Y3jLEfihbzHD4uWRnHewJr_5zzl4f7t-WT2L18vi8XKxE650XnVPWOpC1tZWvnALA0AQFfrKojUUZTQjOtk1owEivMHYwyRptvNZzdnMcPeThc0Qq690w5jT9rSulpauCC17_Afx2Zdo</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Francolini, Giulio</creator><creator>Desideri, Isacco</creator><creator>Meattini, Icro</creator><creator>Becherini, Carlotta</creator><creator>Terziani, Francesca</creator><creator>Olmetto, Emanuela</creator><creator>Camilla Delli Paoli</creator><creator>Donato Pezzulla</creator><creator>Loi, Mauro</creator><creator>Bonomo, Pierluigi</creator><creator>Greto, Daniela</creator><creator>Calusi, Silvia</creator><creator>Casati, Marta</creator><creator>Pallotta, Stefania</creator><creator>Livi, Lorenzo</creator><general>Springer Nature B.V</general><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20190101</creationdate><title>Assessment of a guideline-based heart substructures delineation in left-sided breast cancer patients undergoing adjuvant radiotherapy</title><author>Francolini, Giulio ; Desideri, Isacco ; Meattini, Icro ; Becherini, Carlotta ; Terziani, Francesca ; Olmetto, Emanuela ; Camilla Delli Paoli ; Donato Pezzulla ; Loi, Mauro ; Bonomo, Pierluigi ; Greto, Daniela ; Calusi, Silvia ; Casati, Marta ; Pallotta, Stefania ; Livi, Lorenzo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c767-f61556a085527261aae9b91a7b91d345e0d49965cb9ba4071edfafaf5434733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Algorithms</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Contouring</topic><topic>Damage assessment</topic><topic>Delineation</topic><topic>Health risk assessment</topic><topic>Heart</topic><topic>Immunotherapy</topic><topic>Monoclonal antibodies</topic><topic>Operators</topic><topic>Patients</topic><topic>Radiation therapy</topic><topic>Similarity</topic><topic>Substructures</topic><topic>Targeted cancer therapy</topic><topic>Tracking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Francolini, Giulio</creatorcontrib><creatorcontrib>Desideri, Isacco</creatorcontrib><creatorcontrib>Meattini, Icro</creatorcontrib><creatorcontrib>Becherini, Carlotta</creatorcontrib><creatorcontrib>Terziani, Francesca</creatorcontrib><creatorcontrib>Olmetto, Emanuela</creatorcontrib><creatorcontrib>Camilla Delli Paoli</creatorcontrib><creatorcontrib>Donato Pezzulla</creatorcontrib><creatorcontrib>Loi, Mauro</creatorcontrib><creatorcontrib>Bonomo, Pierluigi</creatorcontrib><creatorcontrib>Greto, Daniela</creatorcontrib><creatorcontrib>Calusi, Silvia</creatorcontrib><creatorcontrib>Casati, Marta</creatorcontrib><creatorcontrib>Pallotta, Stefania</creatorcontrib><creatorcontrib>Livi, Lorenzo</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Strahlentherapie und Onkologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Francolini, Giulio</au><au>Desideri, Isacco</au><au>Meattini, Icro</au><au>Becherini, Carlotta</au><au>Terziani, Francesca</au><au>Olmetto, Emanuela</au><au>Camilla Delli Paoli</au><au>Donato Pezzulla</au><au>Loi, Mauro</au><au>Bonomo, Pierluigi</au><au>Greto, Daniela</au><au>Calusi, Silvia</au><au>Casati, Marta</au><au>Pallotta, Stefania</au><au>Livi, Lorenzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of a guideline-based heart substructures delineation in left-sided breast cancer patients undergoing adjuvant radiotherapy</atitle><jtitle>Strahlentherapie und Onkologie</jtitle><date>2019-01-01</date><risdate>2019</risdate><volume>195</volume><issue>1</issue><spage>43</spage><epage>51</epage><pages>43-51</pages><issn>0179-7158</issn><eissn>1439-099X</eissn><abstract>Background and purposeIn our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014, NCT2236806), assessing preclinical heart damage with heart speckle-tracking ultrasound. To develop a dose constraint related to subclinical heart damage, a reliable delineation of heart substructures based on a pre-existing guideline was made.Patients and methodsHeart substructures of 16 left-sided breast cancer patients included in the SAFE protocol were delineated by five operators. For each substructure, a multi-contour delineation based on a majority vote algorithm (MCD) was created. A consensus-based delineation (CBD) was developed by an independent team of two blinded operators. Dice similarity coefficients (DSC) between volumes delineated by different operators and the MCD were collected and reported, as well as DSC between CBD and MCD.ResultsMean DSCs between heart chambers delineated by each operator and the corresponding MCDs ranged between 0.78 and 0.96. Mean DSC between substructures delineated by all single operators and the corresponding MCD ranged between 0.84 and 0.94. Mean DSC between CBD and the corresponding MCD ranged from 0.89 to 0.97.ConclusionResults showed low inter-observer variability of heart substructure delineation. This constitutes an external validation of the contouring atlas used, allowing a reliable dosimetric assessment of these volumes within the SAFE-2014 trial.</abstract><cop>Heidelberg</cop><pub>Springer Nature B.V</pub><doi>10.1007/s00066-018-1388-x</doi><tpages>9</tpages></addata></record> |
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| subjects | Algorithms Breast cancer Cancer Contouring Damage assessment Delineation Health risk assessment Heart Immunotherapy Monoclonal antibodies Operators Patients Radiation therapy Similarity Substructures Targeted cancer therapy Tracking |
| title | Assessment of a guideline-based heart substructures delineation in left-sided breast cancer patients undergoing adjuvant radiotherapy |
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