Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors

Recently, the cannabinoid receptors CB(1) and CB(2) were shown to modulate bone formation and resorption in vivo, although little is known of the mechanisms underlying this. The effects of cannabinoids on mesenchymal stem cell (MSC) recruitment in whole bone marrow were investigated using either the...

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Veröffentlicht in:	Calcified tissue international 2007-01, Vol.80 (1), p.50-59
Hauptverfasser:	Scutt, A, Williamson, E M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acids - pharmacology Benzoxazines Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - physiology Bones Cannabinoid Receptor Modulators - pharmacology Cannabinoids - pharmacology Cell culture Cells, Cultured Cellular biology Chemical compounds Colony-Forming Units Assay Cyclohexanols - pharmacology Dose-Response Relationship, Drug Endocannabinoids Glycerides - pharmacology Indomethacin - analogs & derivatives Indomethacin - pharmacology Male Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - physiology Morpholines - pharmacology Naphthalenes - pharmacology Rats Rats, Wistar Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - drug effects Receptor, Cannabinoid, CB1 - physiology Receptor, Cannabinoid, CB2 - agonists Receptor, Cannabinoid, CB2 - drug effects Receptor, Cannabinoid, CB2 - physiology Stem cells Stem Cells - cytology Stem Cells - drug effects Stem Cells - physiology Tissue engineering
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