Distribution of 5’ -nucleotidase in the tissues of sheep and the effect of kidney and liver lesions on the activity of the enzyme in plasma and urine
The distribution of 5’-nucleotidase (5’-nt) activity in (he tissues of the sheep differs from that of gamma glutamyl transferase (GGT). Nevertheless, both enzymes are released into the plasma of sheep which have been infected with Fasciota hepatica or in which the bile duct has been ligated. In a sh...
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| Veröffentlicht in: | Research in veterinary science 1985-07, Vol.39 (1), p.103-109 |
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| creator | Ford, E.J.H. Evans, J. |
| description | The distribution of 5’-nucleotidase (5’-nt) activity in (he tissues of the sheep differs from that of gamma glutamyl transferase (GGT). Nevertheless, both enzymes are released into the plasma of sheep which have been infected with Fasciota hepatica or in which the bile duct has been ligated. In a sheep dosed with sporidesmin, a fungal toxin which damages the biliary tract, there was an increase in GGT activity in the plasma and urine but no change in 5’-nt activity. Neither enzyme was released into the plasma or urine of sheep dosed with carbon tetrachloride. In sheep with renal tubular necrosis and hepatocellular necrosis caused by dosage with hexachlorobutadiene, both enzymes were released into the plasma, and GGT, but not 5’-nt activity was found in urine. In sheep with tubular necrosis of the kidney caused by the administration of mercuric chloride, GGT activity, but not 5’-nt, increased in the plasma and urine. |
| doi_str_mv | 10.1016/S0034-5288(18)31782-X |
| format | Article |
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Nevertheless, both enzymes are released into the plasma of sheep which have been infected with Fasciota hepatica or in which the bile duct has been ligated. In a sheep dosed with sporidesmin, a fungal toxin which damages the biliary tract, there was an increase in GGT activity in the plasma and urine but no change in 5’-nt activity. Neither enzyme was released into the plasma or urine of sheep dosed with carbon tetrachloride. In sheep with renal tubular necrosis and hepatocellular necrosis caused by dosage with hexachlorobutadiene, both enzymes were released into the plasma, and GGT, but not 5’-nt activity was found in urine. In sheep with tubular necrosis of the kidney caused by the administration of mercuric chloride, GGT activity, but not 5’-nt, increased in the plasma and urine.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/S0034-5288(18)31782-X</identifier><identifier>PMID: 2863857</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>5'-Nucleotidase ; Animals ; Bile ducts ; Bile Ducts - surgery ; Biliary tract ; blood plasma ; Butadienes - adverse effects ; Carbon tetrachloride ; enzyme activity ; Enzymes ; Fascioliasis - enzymology ; Fascioliasis - veterinary ; Female ; gamma-Glutamyltransferase - metabolism ; Gangrene ; Kidney Diseases - chemically induced ; Kidney Diseases - enzymology ; Kidney Diseases - veterinary ; Kidneys ; Lesions ; Ligation - veterinary ; Liver ; Liver Diseases - enzymology ; Liver Diseases - etiology ; Liver Diseases - veterinary ; Male ; Mercuric chloride ; Mercuric Chloride - poisoning ; Mercury compounds ; Necrosis ; Nucleotidase ; Nucleotidases - metabolism ; Organ Specificity ; Plasma ; Sheep ; Sheep - metabolism ; Sheep Diseases - enzymology ; Sporidesmins - adverse effects ; Tissues ; Urine ; Veterinary medicine</subject><ispartof>Research in veterinary science, 1985-07, Vol.39 (1), p.103-109</ispartof><rights>1985</rights><rights>Copyright Elsevier Limited Jul 1985</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-dc99f891731da680ee7d763cf8c154171d17e17d35add7d7d68ff746df91d7663</citedby><cites>FETCH-LOGICAL-c412t-dc99f891731da680ee7d763cf8c154171d17e17d35add7d7d68ff746df91d7663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S003452881831782X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2863857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ford, E.J.H.</creatorcontrib><creatorcontrib>Evans, J.</creatorcontrib><title>Distribution of 5’ -nucleotidase in the tissues of sheep and the effect of kidney and liver lesions on the activity of the enzyme in plasma and urine</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>The distribution of 5’-nucleotidase (5’-nt) activity in (he tissues of the sheep differs from that of gamma glutamyl transferase (GGT). Nevertheless, both enzymes are released into the plasma of sheep which have been infected with Fasciota hepatica or in which the bile duct has been ligated. In a sheep dosed with sporidesmin, a fungal toxin which damages the biliary tract, there was an increase in GGT activity in the plasma and urine but no change in 5’-nt activity. Neither enzyme was released into the plasma or urine of sheep dosed with carbon tetrachloride. In sheep with renal tubular necrosis and hepatocellular necrosis caused by dosage with hexachlorobutadiene, both enzymes were released into the plasma, and GGT, but not 5’-nt activity was found in urine. In sheep with tubular necrosis of the kidney caused by the administration of mercuric chloride, GGT activity, but not 5’-nt, increased in the plasma and urine.</description><subject>5'-Nucleotidase</subject><subject>Animals</subject><subject>Bile ducts</subject><subject>Bile Ducts - surgery</subject><subject>Biliary tract</subject><subject>blood plasma</subject><subject>Butadienes - adverse effects</subject><subject>Carbon tetrachloride</subject><subject>enzyme activity</subject><subject>Enzymes</subject><subject>Fascioliasis - enzymology</subject><subject>Fascioliasis - veterinary</subject><subject>Female</subject><subject>gamma-Glutamyltransferase - metabolism</subject><subject>Gangrene</subject><subject>Kidney Diseases - chemically induced</subject><subject>Kidney Diseases - enzymology</subject><subject>Kidney Diseases - veterinary</subject><subject>Kidneys</subject><subject>Lesions</subject><subject>Ligation - veterinary</subject><subject>Liver</subject><subject>Liver Diseases - enzymology</subject><subject>Liver Diseases - etiology</subject><subject>Liver Diseases - veterinary</subject><subject>Male</subject><subject>Mercuric chloride</subject><subject>Mercuric Chloride - poisoning</subject><subject>Mercury compounds</subject><subject>Necrosis</subject><subject>Nucleotidase</subject><subject>Nucleotidases - metabolism</subject><subject>Organ Specificity</subject><subject>Plasma</subject><subject>Sheep</subject><subject>Sheep - metabolism</subject><subject>Sheep Diseases - enzymology</subject><subject>Sporidesmins - adverse effects</subject><subject>Tissues</subject><subject>Urine</subject><subject>Veterinary medicine</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS1EVaaFR6iIxIYuUnzjxHZWqCp_lSp1USp1Z7n2NXXJJIPtjDSseAvE6_EkOMmoW1aWfL5zfH0uISdAz4ACf3dDKavLppLyLchTBkJW5d0zsoKGVWXFOTwnqyfkBTmK8ZFSWgOIQ3JYSc5kI1bk9wcfU_D3Y_JDXwyuaP7--lOU_Wg6HJK3OmLh-yI9YJF8jCPGCYoPiJtC93YW0Dk0abr_7m2Pu1no_BZD0WHMudmzRGiT_Nan3cTOzv7nbj0_sOl0XOvZOQbf40ty4HQX8dX-PCa3nz5-vfhSXl1_vrw4vypNDVUqrWlbJ1sQDKzmkiIKKzgzThpoahBgQSAIyxptbZYsl86JmlvXQgY5OyZvltxNGH7k3yX1OIyhz0-qCqq2FkIwmqlmoUwYYgzo1Cb4tQ47BVRN21DzNtRUtQKp5m2ou-w72aeP92u0T659_Vl_vehOD0p_Cz6q25uKAqNQN6yup_neLwTmErYeg4rGY2_Q-pBLV3bw_5nhH79ypUs</recordid><startdate>198507</startdate><enddate>198507</enddate><creator>Ford, E.J.H.</creator><creator>Evans, J.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>198507</creationdate><title>Distribution of 5’ -nucleotidase in the tissues of sheep and the effect of kidney and liver lesions on the activity of the enzyme in plasma and urine</title><author>Ford, E.J.H. ; Evans, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-dc99f891731da680ee7d763cf8c154171d17e17d35add7d7d68ff746df91d7663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>5'-Nucleotidase</topic><topic>Animals</topic><topic>Bile ducts</topic><topic>Bile Ducts - surgery</topic><topic>Biliary tract</topic><topic>blood plasma</topic><topic>Butadienes - adverse effects</topic><topic>Carbon tetrachloride</topic><topic>enzyme activity</topic><topic>Enzymes</topic><topic>Fascioliasis - enzymology</topic><topic>Fascioliasis - veterinary</topic><topic>Female</topic><topic>gamma-Glutamyltransferase - metabolism</topic><topic>Gangrene</topic><topic>Kidney Diseases - chemically induced</topic><topic>Kidney Diseases - enzymology</topic><topic>Kidney Diseases - veterinary</topic><topic>Kidneys</topic><topic>Lesions</topic><topic>Ligation - veterinary</topic><topic>Liver</topic><topic>Liver Diseases - enzymology</topic><topic>Liver Diseases - etiology</topic><topic>Liver Diseases - veterinary</topic><topic>Male</topic><topic>Mercuric chloride</topic><topic>Mercuric Chloride - poisoning</topic><topic>Mercury compounds</topic><topic>Necrosis</topic><topic>Nucleotidase</topic><topic>Nucleotidases - metabolism</topic><topic>Organ Specificity</topic><topic>Plasma</topic><topic>Sheep</topic><topic>Sheep - metabolism</topic><topic>Sheep Diseases - enzymology</topic><topic>Sporidesmins - adverse effects</topic><topic>Tissues</topic><topic>Urine</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ford, E.J.H.</creatorcontrib><creatorcontrib>Evans, J.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ford, E.J.H.</au><au>Evans, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of 5’ -nucleotidase in the tissues of sheep and the effect of kidney and liver lesions on the activity of the enzyme in plasma and urine</atitle><jtitle>Research in veterinary science</jtitle><addtitle>Res Vet Sci</addtitle><date>1985-07</date><risdate>1985</risdate><volume>39</volume><issue>1</issue><spage>103</spage><epage>109</epage><pages>103-109</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>The distribution of 5’-nucleotidase (5’-nt) activity in (he tissues of the sheep differs from that of gamma glutamyl transferase (GGT). Nevertheless, both enzymes are released into the plasma of sheep which have been infected with Fasciota hepatica or in which the bile duct has been ligated. In a sheep dosed with sporidesmin, a fungal toxin which damages the biliary tract, there was an increase in GGT activity in the plasma and urine but no change in 5’-nt activity. Neither enzyme was released into the plasma or urine of sheep dosed with carbon tetrachloride. In sheep with renal tubular necrosis and hepatocellular necrosis caused by dosage with hexachlorobutadiene, both enzymes were released into the plasma, and GGT, but not 5’-nt activity was found in urine. In sheep with tubular necrosis of the kidney caused by the administration of mercuric chloride, GGT activity, but not 5’-nt, increased in the plasma and urine.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>2863857</pmid><doi>10.1016/S0034-5288(18)31782-X</doi><tpages>7</tpages></addata></record> |
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| ispartof | Research in veterinary science, 1985-07, Vol.39 (1), p.103-109 |
| issn | 0034-5288 1532-2661 |
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| subjects | 5'-Nucleotidase Animals Bile ducts Bile Ducts - surgery Biliary tract blood plasma Butadienes - adverse effects Carbon tetrachloride enzyme activity Enzymes Fascioliasis - enzymology Fascioliasis - veterinary Female gamma-Glutamyltransferase - metabolism Gangrene Kidney Diseases - chemically induced Kidney Diseases - enzymology Kidney Diseases - veterinary Kidneys Lesions Ligation - veterinary Liver Liver Diseases - enzymology Liver Diseases - etiology Liver Diseases - veterinary Male Mercuric chloride Mercuric Chloride - poisoning Mercury compounds Necrosis Nucleotidase Nucleotidases - metabolism Organ Specificity Plasma Sheep Sheep - metabolism Sheep Diseases - enzymology Sporidesmins - adverse effects Tissues Urine Veterinary medicine |
| title | Distribution of 5’ -nucleotidase in the tissues of sheep and the effect of kidney and liver lesions on the activity of the enzyme in plasma and urine |
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