FOXRED1 silencing in mice: a possible animal model for Leigh syndrome

Leigh syndrome (LS) is one of the most puzzling mitochondrial disorders, which is also known as subacute necrotizing encephalopathy. It has an incidence of 1 in 77,000 live births worldwide with poor prognosis. Currently, there is a poor understanding of the underlying pathophysiological mechanisms...

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Veröffentlicht in:	Metabolic brain disease 2019-02, Vol.34 (1), p.367-372
Hauptverfasser:	Salama, Mohamed, El-Desouky, Sara, Alsayed, Aziza, El-Hussiny, Mahmoud, Moustafa, Abdelrahman, Taalab, Yasmeen, Mohamed, Wael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Biochemistry Biomedical and Life Sciences Biomedicine Biosynthesis Brain research Corpus striatum Corpus Striatum - pathology Degeneration Disease Models, Animal Dopamine receptors Echoes Encephalopathy Gene Silencing Genes Laboratory animals Leigh Disease - genetics Leigh Disease - pathology Medical treatment Medicine Metabolic Diseases Mice Mitochondria Molecular Chaperones - genetics Mutation Neostriatum Neurology Neurosciences Oncology Parkinson's disease Proteins Ribonucleic acid RNA Short Communication siRNA Substantia nigra Substantia Nigra - pathology
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