Scalable culture of human induced pluripotent cells on microcarriers under xeno‐free conditions using single‐use vertical‐wheel™ bioreactors

BACKGROUND Human induced pluripotent stem cells (hiPSC) are expected to become powerful tools for disease modelling, for the discovery and testing of new drugs and, ultimately, for regenerative therapies. The success of these applications depends on the development of scalable bioprocesses capable o...

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Veröffentlicht in:	Journal of chemical technology and biotechnology (1986) 2018-12, Vol.93 (12), p.3597-3606
Hauptverfasser:	Rodrigues, Carlos AV, Silva, Teresa P, Nogueira, Diogo ES, Fernandes, Tiago G, Hashimura, Yas, Wesselschmidt, Robin, Diogo, Maria Margarida, Lee, Brian, Cabral, Joaquim MS
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioreactors Blood vessels Cell culture Feasibility studies Good Manufacturing Practice induced pluripotent stem cells Manufacturing microcarriers Organic chemistry Pluripotency Precision medicine Stem cells vertical‐wheel bioreactors xeno‐free
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