Hepatoprotective activity of Uncaria tomentosa extract against sub-chronic exposure to fipronil in male rats
The effects of fipronil (FPN) on the liver of rats were studied. Rats ( n = 6) were treated with 9.7 mg/kg (1/10 of FPN LD 50 ), and other rats ( n = 6) received 120 mg/kg of 10% Uncaria tomentosa extract, while a mixture of 9.7 mg/kg FPN and 120 mg/kg of 10% Uncaria tomentosa extract were adminis...
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| description | The effects of fipronil (FPN) on the liver of rats were studied. Rats (
n
= 6) were treated with 9.7 mg/kg (1/10 of FPN LD
50
), and other rats (
n
= 6) received 120 mg/kg of 10%
Uncaria tomentosa
extract, while a mixture of 9.7 mg/kg FPN and 120 mg/kg of 10%
Uncaria tomentosa
extract were administered orally to the rats (
n
= 6) daily for 6 weeks. Body, hepatic weights, liver enzymes, and lipid profile were determined. Hepatic activities of MDA, TNO, TAC, TNF-α, and IL-6 in liver homogenate were measured. Immunohistochemistry of NF-kB and liver histopathology were performed. Fipronil-treated rats had a significant (
P
= 0.02) lower weight gain. Moreover, relative liver weight was significantly (
P
= 0.003) increased in FPN-treated rats. Rats administrated with FPN exhibited a significantly (
P
= 0.02) higher liver enzymes and promoted levels of MDA, TNO, TNF-α, and IL-6 (
P
|
| doi_str_mv | 10.1007/s11356-018-3615-5 |
| format | Article |
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n
= 6) were treated with 9.7 mg/kg (1/10 of FPN LD
50
), and other rats (
n
= 6) received 120 mg/kg of 10%
Uncaria tomentosa
extract, while a mixture of 9.7 mg/kg FPN and 120 mg/kg of 10%
Uncaria tomentosa
extract were administered orally to the rats (
n
= 6) daily for 6 weeks. Body, hepatic weights, liver enzymes, and lipid profile were determined. Hepatic activities of MDA, TNO, TAC, TNF-α, and IL-6 in liver homogenate were measured. Immunohistochemistry of NF-kB and liver histopathology were performed. Fipronil-treated rats had a significant (
P
= 0.02) lower weight gain. Moreover, relative liver weight was significantly (
P
= 0.003) increased in FPN-treated rats. Rats administrated with FPN exhibited a significantly (
P
= 0.02) higher liver enzymes and promoted levels of MDA, TNO, TNF-α, and IL-6 (
P
< 0.0001) than that in the other groups. Immunostaining of NF-κB was increased (
P
< 0.0001) in FPN-treated rats. Interestingly,
Uncaria tomentosa
alone or with FPN decreased the liver immunostaining of NF-κB. In conclusion, FPN produced liver injury through lipid peroxidation and stimulation of NF-κB. However,
Uncaria tomentosa
combated the oxidative stress and liver damage induced by FPN via inhibition of NF-κB.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-018-3615-5</identifier><identifier>PMID: 30387063</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Antioxidants - metabolism ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Body weight gain ; Cat's Claw - chemistry ; Cell Line ; Chemical and Drug Induced Liver Injury - metabolism ; Chemical and Drug Induced Liver Injury - prevention & control ; Chronic exposure ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental Pollutants - adverse effects ; Environmental science ; Enzymes ; Fipronil ; Histopathology ; Immunohistochemistry ; Insecticides ; Insecticides - adverse effects ; Interleukin 6 ; Interleukin-6 - metabolism ; Lipid peroxidation ; Lipid Peroxidation - drug effects ; Lipids ; Liver ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Male ; Malondialdehyde - metabolism ; NF-kappa B - metabolism ; NF-κB protein ; Oxidative stress ; Oxidative Stress - drug effects ; Peroxidation ; Pesticides ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Protective Agents - pharmacology ; Protective Agents - therapeutic use ; Pyrazoles - adverse effects ; Rats ; Rats, Wistar ; Research Article ; Rodents ; Tumor Necrosis Factor-alpha - antagonists & inhibitors ; Tumor necrosis factor-α ; Uncaria tomentosa ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2019, Vol.26 (1), p.199-207</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Environmental Science and Pollution Research is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-a8baa4eb0e4f34c5247e188ced212f4619e5e1a5ff7013a9be822bf24aa275a63</citedby><cites>FETCH-LOGICAL-c409t-a8baa4eb0e4f34c5247e188ced212f4619e5e1a5ff7013a9be822bf24aa275a63</cites><orcidid>0000-0003-2494-5407</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-018-3615-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-018-3615-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27933,27934,41497,42566,51328</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30387063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elgawish, Rania Abdelrahman</creatorcontrib><creatorcontrib>Abdelrazek, Heba M. A.</creatorcontrib><creatorcontrib>Ismail, Shimaa A. A.</creatorcontrib><creatorcontrib>Loutfy, Naglaa M.</creatorcontrib><creatorcontrib>Soliman, Mohamed T. A.</creatorcontrib><title>Hepatoprotective activity of Uncaria tomentosa extract against sub-chronic exposure to fipronil in male rats</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>The effects of fipronil (FPN) on the liver of rats were studied. Rats (
n
= 6) were treated with 9.7 mg/kg (1/10 of FPN LD
50
), and other rats (
n
= 6) received 120 mg/kg of 10%
Uncaria tomentosa
extract, while a mixture of 9.7 mg/kg FPN and 120 mg/kg of 10%
Uncaria tomentosa
extract were administered orally to the rats (
n
= 6) daily for 6 weeks. Body, hepatic weights, liver enzymes, and lipid profile were determined. Hepatic activities of MDA, TNO, TAC, TNF-α, and IL-6 in liver homogenate were measured. Immunohistochemistry of NF-kB and liver histopathology were performed. Fipronil-treated rats had a significant (
P
= 0.02) lower weight gain. Moreover, relative liver weight was significantly (
P
= 0.003) increased in FPN-treated rats. Rats administrated with FPN exhibited a significantly (
P
= 0.02) higher liver enzymes and promoted levels of MDA, TNO, TNF-α, and IL-6 (
P
< 0.0001) than that in the other groups. Immunostaining of NF-κB was increased (
P
< 0.0001) in FPN-treated rats. Interestingly,
Uncaria tomentosa
alone or with FPN decreased the liver immunostaining of NF-κB. In conclusion, FPN produced liver injury through lipid peroxidation and stimulation of NF-κB. However,
Uncaria tomentosa
combated the oxidative stress and liver damage induced by FPN via inhibition of NF-κB.</description><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Body weight gain</subject><subject>Cat's Claw - chemistry</subject><subject>Cell Line</subject><subject>Chemical and Drug Induced Liver Injury - metabolism</subject><subject>Chemical and Drug Induced Liver Injury - prevention & control</subject><subject>Chronic exposure</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental Pollutants - adverse effects</subject><subject>Environmental science</subject><subject>Enzymes</subject><subject>Fipronil</subject><subject>Histopathology</subject><subject>Immunohistochemistry</subject><subject>Insecticides</subject><subject>Insecticides - adverse effects</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - metabolism</subject><subject>Lipid peroxidation</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipids</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>NF-kappa B - metabolism</subject><subject>NF-κB protein</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Peroxidation</subject><subject>Pesticides</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Protective Agents - pharmacology</subject><subject>Protective Agents - therapeutic use</subject><subject>Pyrazoles - adverse effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Research Article</subject><subject>Rodents</subject><subject>Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><subject>Tumor necrosis factor-α</subject><subject>Uncaria tomentosa</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kE1LAzEQhoMotlZ_gBcJeI7ma7-OUtQKBS_2HGa3k7ql3axJVuy_N6VVT54GZp55Z3gIuRb8TnBe3AchVJYzLkqmcpGx7ISMRS40K3RVnZIxr7RmQmk9IhchrDmXvJLFORkprsqC52pMNjPsIbreu4hNbD-Rwr60cUedpYuuAd8CjW6LXXQBKH5FnwgKK2i7EGkYata8e9e1TZr1LgweE05t2--bG9p2dAsbpB5iuCRnFjYBr451QhZPj2_TGZu_Pr9MH-as0byKDMoaQGPNUVulm0zqAkVZNriUQlqdiwozFJBZW3ChoKqxlLK2UgPIIoNcTcjtITf98DFgiGbtBt-lkyYlFKVWZc4TJQ5U410IHq3pfbsFvzOCm71fc_Brkl-z92uytHNzTB7qLS5_N36EJkAegJBG3Qr93-n_U78Bry-Hzw</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Elgawish, Rania Abdelrahman</creator><creator>Abdelrazek, Heba M. A.</creator><creator>Ismail, Shimaa A. A.</creator><creator>Loutfy, Naglaa M.</creator><creator>Soliman, Mohamed T. 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A. ; Ismail, Shimaa A. A. ; Loutfy, Naglaa M. ; Soliman, Mohamed T. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-a8baa4eb0e4f34c5247e188ced212f4619e5e1a5ff7013a9be822bf24aa275a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Body weight gain</topic><topic>Cat's Claw - chemistry</topic><topic>Cell Line</topic><topic>Chemical and Drug Induced Liver Injury - metabolism</topic><topic>Chemical and Drug Induced Liver Injury - prevention & control</topic><topic>Chronic exposure</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Environmental Pollutants - adverse effects</topic><topic>Environmental science</topic><topic>Enzymes</topic><topic>Fipronil</topic><topic>Histopathology</topic><topic>Immunohistochemistry</topic><topic>Insecticides</topic><topic>Insecticides - adverse effects</topic><topic>Interleukin 6</topic><topic>Interleukin-6 - metabolism</topic><topic>Lipid peroxidation</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lipids</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>NF-kappa B - metabolism</topic><topic>NF-κB protein</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Peroxidation</topic><topic>Pesticides</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Protective Agents - pharmacology</topic><topic>Protective Agents - therapeutic use</topic><topic>Pyrazoles - adverse effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Research Article</topic><topic>Rodents</topic><topic>Tumor Necrosis Factor-alpha - antagonists & inhibitors</topic><topic>Tumor necrosis factor-α</topic><topic>Uncaria tomentosa</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollution Control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elgawish, Rania Abdelrahman</creatorcontrib><creatorcontrib>Abdelrazek, Heba M. 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A.</au><au>Ismail, Shimaa A. A.</au><au>Loutfy, Naglaa M.</au><au>Soliman, Mohamed T. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatoprotective activity of Uncaria tomentosa extract against sub-chronic exposure to fipronil in male rats</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2019</date><risdate>2019</risdate><volume>26</volume><issue>1</issue><spage>199</spage><epage>207</epage><pages>199-207</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>The effects of fipronil (FPN) on the liver of rats were studied. Rats (
n
= 6) were treated with 9.7 mg/kg (1/10 of FPN LD
50
), and other rats (
n
= 6) received 120 mg/kg of 10%
Uncaria tomentosa
extract, while a mixture of 9.7 mg/kg FPN and 120 mg/kg of 10%
Uncaria tomentosa
extract were administered orally to the rats (
n
= 6) daily for 6 weeks. Body, hepatic weights, liver enzymes, and lipid profile were determined. Hepatic activities of MDA, TNO, TAC, TNF-α, and IL-6 in liver homogenate were measured. Immunohistochemistry of NF-kB and liver histopathology were performed. Fipronil-treated rats had a significant (
P
= 0.02) lower weight gain. Moreover, relative liver weight was significantly (
P
= 0.003) increased in FPN-treated rats. Rats administrated with FPN exhibited a significantly (
P
= 0.02) higher liver enzymes and promoted levels of MDA, TNO, TNF-α, and IL-6 (
P
< 0.0001) than that in the other groups. Immunostaining of NF-κB was increased (
P
< 0.0001) in FPN-treated rats. Interestingly,
Uncaria tomentosa
alone or with FPN decreased the liver immunostaining of NF-κB. In conclusion, FPN produced liver injury through lipid peroxidation and stimulation of NF-κB. However,
Uncaria tomentosa
combated the oxidative stress and liver damage induced by FPN via inhibition of NF-κB.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30387063</pmid><doi>10.1007/s11356-018-3615-5</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2494-5407</orcidid></addata></record> |
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| identifier | ISSN: 0944-1344 |
| ispartof | Environmental science and pollution research international, 2019, Vol.26 (1), p.199-207 |
| issn | 0944-1344 1614-7499 |
| language | eng |
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| source | MEDLINE; Springer Journals |
| subjects | Animals Antioxidants - metabolism Antioxidants - pharmacology Antioxidants - therapeutic use Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Body weight gain Cat's Claw - chemistry Cell Line Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - prevention & control Chronic exposure Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental Pollutants - adverse effects Environmental science Enzymes Fipronil Histopathology Immunohistochemistry Insecticides Insecticides - adverse effects Interleukin 6 Interleukin-6 - metabolism Lipid peroxidation Lipid Peroxidation - drug effects Lipids Liver Liver - drug effects Liver - metabolism Liver - pathology Male Malondialdehyde - metabolism NF-kappa B - metabolism NF-κB protein Oxidative stress Oxidative Stress - drug effects Peroxidation Pesticides Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Protective Agents - pharmacology Protective Agents - therapeutic use Pyrazoles - adverse effects Rats Rats, Wistar Research Article Rodents Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor necrosis factor-α Uncaria tomentosa Waste Water Technology Water Management Water Pollution Control |
| title | Hepatoprotective activity of Uncaria tomentosa extract against sub-chronic exposure to fipronil in male rats |
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