Hepatoprotective activity of Uncaria tomentosa extract against sub-chronic exposure to fipronil in male rats

The effects of fipronil (FPN) on the liver of rats were studied. Rats ( n = 6) were treated with 9.7 mg/kg (1/10 of FPN LD 50 ), and other rats ( n = 6) received 120 mg/kg of 10% Uncaria tomentosa extract, while a mixture of 9.7 mg/kg FPN and 120 mg/kg of 10% Uncaria tomentosa extract were adminis...

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Veröffentlicht in:	Environmental science and pollution research international 2019, Vol.26 (1), p.199-207
Hauptverfasser:	Elgawish, Rania Abdelrahman, Abdelrazek, Heba M. A., Ismail, Shimaa A. A., Loutfy, Naglaa M., Soliman, Mohamed T. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Antioxidants - pharmacology Antioxidants - therapeutic use Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Body weight gain Cat's Claw - chemistry Cell Line Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - prevention & control Chronic exposure Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental Pollutants - adverse effects Environmental science Enzymes Fipronil Histopathology Immunohistochemistry Insecticides Insecticides - adverse effects Interleukin 6 Interleukin-6 - metabolism Lipid peroxidation Lipid Peroxidation - drug effects Lipids Liver Liver - drug effects Liver - metabolism Liver - pathology Male Malondialdehyde - metabolism NF-kappa B - metabolism NF-κB protein Oxidative stress Oxidative Stress - drug effects Peroxidation Pesticides Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Protective Agents - pharmacology Protective Agents - therapeutic use Pyrazoles - adverse effects Rats Rats, Wistar Research Article Rodents Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor necrosis factor-α Uncaria tomentosa Waste Water Technology Water Management Water Pollution Control
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Zusammenfassung:	The effects of fipronil (FPN) on the liver of rats were studied. Rats ( n = 6) were treated with 9.7 mg/kg (1/10 of FPN LD 50 ), and other rats ( n = 6) received 120 mg/kg of 10% Uncaria tomentosa extract, while a mixture of 9.7 mg/kg FPN and 120 mg/kg of 10% Uncaria tomentosa extract were administered orally to the rats ( n = 6) daily for 6 weeks. Body, hepatic weights, liver enzymes, and lipid profile were determined. Hepatic activities of MDA, TNO, TAC, TNF-α, and IL-6 in liver homogenate were measured. Immunohistochemistry of NF-kB and liver histopathology were performed. Fipronil-treated rats had a significant ( P = 0.02) lower weight gain. Moreover, relative liver weight was significantly ( P = 0.003) increased in FPN-treated rats. Rats administrated with FPN exhibited a significantly ( P = 0.02) higher liver enzymes and promoted levels of MDA, TNO, TNF-α, and IL-6 ( P
ISSN:	0944-1344 1614-7499
DOI:	10.1007/s11356-018-3615-5