The antioxidant effect of derivatives pyroglutamic lactam
Diphenylpicrylhydrazyl (DPPH) is widely used for quickly accessing the ability of polyphenols to transfer labile H atoms to radicals. The antioxidant activity of all the synthesized compounds was screened by DPPH method. Compound (4) showed 54% antioxidant potential while all other compounds were fo...
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| creator | Atisya, Rohadi Lazim, Azwani Mat Hasbullah, Siti Aishah |
| description | Diphenylpicrylhydrazyl (DPPH) is widely used for quickly accessing the ability of polyphenols to transfer labile H atoms to radicals. The antioxidant activity of all the synthesized compounds was screened by DPPH method. Compound (4) showed 54% antioxidant potential while all other compounds were found to have moderate to have moderate to mild antioxidant activity ranging from 47–52%. Pyroglutamic lactams have been synthesized stereoselectively in racemic form from levulinic acid as bifunctional adduct using convertible isocyanide in one-pot Ugi 4-center-3-component condensation reaction (U-4C-3CR). The product formed provides biologically interesting products in excellent yields in a short reaction time. The structures of the synthesized compounds were elucidated using spectroscopic data and elemental analysis. |
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The antioxidant activity of all the synthesized compounds was screened by DPPH method. Compound (4) showed 54% antioxidant potential while all other compounds were found to have moderate to have moderate to mild antioxidant activity ranging from 47–52%. Pyroglutamic lactams have been synthesized stereoselectively in racemic form from levulinic acid as bifunctional adduct using convertible isocyanide in one-pot Ugi 4-center-3-component condensation reaction (U-4C-3CR). The product formed provides biologically interesting products in excellent yields in a short reaction time. 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The structures of the synthesized compounds were elucidated using spectroscopic data and elemental analysis.</description><subject>Amides</subject><subject>Antioxidants</subject><subject>Chemical synthesis</subject><subject>Condensates</subject><subject>Levulinic acid</subject><subject>Polyphenols</subject><subject>Reaction time</subject><issn>0094-243X</issn><issn>1551-7616</issn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2014</creationdate><recordtype>conference_proceeding</recordtype><recordid>eNqNiksKwjAUAIMoWD93CLguJGnTmLUoHqALdyWkL5pSm5pP0dvbhQdwNQMzC5RRzmkuKlotUUaILHNWFrc12oTQEcKkEMcMyfoBWA3RurdtZ2IwBnTEzuAWvJ1UtBMEPH68u_cpqqfVuFd6lh1aGdUH2P-4RYfLuT5d89G7V4IQm84lP8ypYZQJwRnjsvjv-gLKkzh_</recordid><startdate>20140106</startdate><enddate>20140106</enddate><creator>Atisya, Rohadi</creator><creator>Lazim, Azwani Mat</creator><creator>Hasbullah, Siti Aishah</creator><general>American Institute of Physics</general><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope></search><sort><creationdate>20140106</creationdate><title>The antioxidant effect of derivatives pyroglutamic lactam</title><author>Atisya, Rohadi ; Lazim, Azwani Mat ; Hasbullah, Siti Aishah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_21277522593</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Amides</topic><topic>Antioxidants</topic><topic>Chemical synthesis</topic><topic>Condensates</topic><topic>Levulinic acid</topic><topic>Polyphenols</topic><topic>Reaction time</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Atisya, Rohadi</creatorcontrib><creatorcontrib>Lazim, Azwani Mat</creatorcontrib><creatorcontrib>Hasbullah, Siti Aishah</creatorcontrib><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Atisya, Rohadi</au><au>Lazim, Azwani Mat</au><au>Hasbullah, Siti Aishah</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>The antioxidant effect of derivatives pyroglutamic lactam</atitle><btitle>AIP conference proceedings</btitle><date>2014-01-06</date><risdate>2014</risdate><volume>1571</volume><issue>1</issue><epage>805</epage><issn>0094-243X</issn><eissn>1551-7616</eissn><abstract>Diphenylpicrylhydrazyl (DPPH) is widely used for quickly accessing the ability of polyphenols to transfer labile H atoms to radicals. 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| subjects | Amides Antioxidants Chemical synthesis Condensates Levulinic acid Polyphenols Reaction time |
| title | The antioxidant effect of derivatives pyroglutamic lactam |
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