Nrf2 Signaling Elicits a Neuroprotective Role Against PFOS-mediated Oxidative Damage and Apoptosis

Perfluorooctanesulfonate (PFOS) may cause neurotoxicity through the initiation of oxidative stress. In the current study, we investigated the role of anti-oxidant nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in PFOS-induced neurotoxicity. We found that human neuroblastoma SH-SY5Y cells...

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Veröffentlicht in:	Neurochemical research 2018-12, Vol.43 (12), p.2446-2459
Hauptverfasser:	Sun, Pingping, Nie, Xiaoke, Chen, Xiaoxu, Yin, Lifeng, Luo, Jiashan, Sun, Lingli, Wan, Chunhua, Jiang, Shengyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Alkanesulfonic Acids - toxicity Apoptosis Apoptosis - drug effects Apoptosis - physiology Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cell counters Cell death Cell Line, Tumor Dose-Response Relationship, Drug Exposure Fluorocarbons - toxicity Heme Heme oxygenase (decyclizing) Humans Membrane potential Mitochondria Morphology Neurochemistry Neurology Neuroprotection Neuroprotection - drug effects Neuroprotection - physiology Neurosciences Neurotoxicity NF-E2-Related Factor 2 - metabolism Original Paper Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Oxygenase Perfluorooctane sulfonic acid Proteins Reactive oxygen species Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Signaling Transcription Viability
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