Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review)
Ischemic stroke is one of the main causes of death and disablement globally. The NLR family pyrin domain containing 3 (NLRP3) inflammasome is established as a sensor of detecting cellular damage and modulating inflammatory responses to injury during the progress of ischemic stroke. Inhibiting or blo...
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| Veröffentlicht in: | International journal of molecular medicine 2018-12, Vol.42 (6), p.2979-2990 |
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| container_title | International journal of molecular medicine |
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| creator | Ma, Chongyang Liu, Shuling Zhang, Shuang Xu, Tian Yu, Xue Gao, Yushan Zhai, Changming Li, Changxiang Lei, Chaofang Fan, Shuning Chen, Yuxi Tian, Huiling Wang, Qingguo Cheng, Fafeng Wang, Xueqian |
| description | Ischemic stroke is one of the main causes of death and disablement globally. The NLR family pyrin domain containing 3 (NLRP3) inflammasome is established as a sensor of detecting cellular damage and modulating inflammatory responses to injury during the progress of ischemic stroke. Inhibiting or blocking the NLRP3 inflammasome at different stages, including expression, assembly, and secretion, may have great promise to improve the neurological deficits during ischemic stroke. The current review provides a comprehensive summary of the current understanding in the literature of the molecular structure, expression, and assembly of the NLRP3 inflammasome, and highlights its potential as a novel therapeutic target for ischemic stroke. |
| doi_str_mv | 10.3892/ijmm.2018.3911 |
| format | Article |
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The NLR family pyrin domain containing 3 (NLRP3) inflammasome is established as a sensor of detecting cellular damage and modulating inflammatory responses to injury during the progress of ischemic stroke. Inhibiting or blocking the NLRP3 inflammasome at different stages, including expression, assembly, and secretion, may have great promise to improve the neurological deficits during ischemic stroke. The current review provides a comprehensive summary of the current understanding in the literature of the molecular structure, expression, and assembly of the NLRP3 inflammasome, and highlights its potential as a novel therapeutic target for ischemic stroke.</description><identifier>ISSN: 1107-3756</identifier><identifier>EISSN: 1791-244X</identifier><identifier>DOI: 10.3892/ijmm.2018.3911</identifier><identifier>PMID: 30280193</identifier><language>eng</language><publisher>Greece: Spandidos Publications UK Ltd</publisher><subject>Animals ; Apoptosis ; Biomarkers ; Cardiovascular disease ; Cytokines ; Edema ; Gene Expression ; Humans ; Inflammasomes - metabolism ; Inflammation ; Ischemia ; Molecular Targeted Therapy ; Multiprotein Complexes - chemistry ; Multiprotein Complexes - metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism ; Phosphorylation ; Proteins ; Rodents ; Signal Transduction ; Stroke - drug therapy ; Stroke - etiology ; Stroke - metabolism ; Stroke - pathology</subject><ispartof>International journal of molecular medicine, 2018-12, Vol.42 (6), p.2979-2990</ispartof><rights>Copyright Spandidos Publications UK Ltd. 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-9265df3d902f8751e1df4008ea46929527d81338d7f13a26d3f87415ff045e4b3</citedby><cites>FETCH-LOGICAL-c363t-9265df3d902f8751e1df4008ea46929527d81338d7f13a26d3f87415ff045e4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30280193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Chongyang</creatorcontrib><creatorcontrib>Liu, Shuling</creatorcontrib><creatorcontrib>Zhang, Shuang</creatorcontrib><creatorcontrib>Xu, Tian</creatorcontrib><creatorcontrib>Yu, Xue</creatorcontrib><creatorcontrib>Gao, Yushan</creatorcontrib><creatorcontrib>Zhai, Changming</creatorcontrib><creatorcontrib>Li, Changxiang</creatorcontrib><creatorcontrib>Lei, Chaofang</creatorcontrib><creatorcontrib>Fan, Shuning</creatorcontrib><creatorcontrib>Chen, Yuxi</creatorcontrib><creatorcontrib>Tian, Huiling</creatorcontrib><creatorcontrib>Wang, Qingguo</creatorcontrib><creatorcontrib>Cheng, Fafeng</creatorcontrib><creatorcontrib>Wang, Xueqian</creatorcontrib><title>Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review)</title><title>International journal of molecular medicine</title><addtitle>Int J Mol Med</addtitle><description>Ischemic stroke is one of the main causes of death and disablement globally. The NLR family pyrin domain containing 3 (NLRP3) inflammasome is established as a sensor of detecting cellular damage and modulating inflammatory responses to injury during the progress of ischemic stroke. Inhibiting or blocking the NLRP3 inflammasome at different stages, including expression, assembly, and secretion, may have great promise to improve the neurological deficits during ischemic stroke. The current review provides a comprehensive summary of the current understanding in the literature of the molecular structure, expression, and assembly of the NLRP3 inflammasome, and highlights its potential as a novel therapeutic target for ischemic stroke.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Biomarkers</subject><subject>Cardiovascular disease</subject><subject>Cytokines</subject><subject>Edema</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Inflammasomes - metabolism</subject><subject>Inflammation</subject><subject>Ischemia</subject><subject>Molecular Targeted Therapy</subject><subject>Multiprotein Complexes - chemistry</subject><subject>Multiprotein Complexes - metabolism</subject><subject>NLR Family, Pyrin Domain-Containing 3 Protein - metabolism</subject><subject>Phosphorylation</subject><subject>Proteins</subject><subject>Rodents</subject><subject>Signal Transduction</subject><subject>Stroke - drug therapy</subject><subject>Stroke - etiology</subject><subject>Stroke - metabolism</subject><subject>Stroke - pathology</subject><issn>1107-3756</issn><issn>1791-244X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNo9kE1P3DAQhq2KqrvQXntElrjAIVt_JvaxQrQgrVqEisQt8sbjXS9JnNreRfwG_nQTFnqaV5pnXmkehL5SsuBKs29-23ULRqhacE3pBzSnlaYFE-LhaMyUVAWvZDlDxyltCWFSaPUJzThhilDN5-jlau8t9A1g01s8QEwDNNnvAbsQcd4AjqEFHNxr_rW8u-XY9641XWdS6AAnv-5N6_s1HkzePJnncY19ajbQ-QanHMPjodvnNHVEM8Auj6shZOizNy0-v4O9h6eLz-ijM22CL2_zBN3_uPpzeV0sf_-8ufy-LBpe8lxoVkrruNWEOVVJCtQ6QYgCI0rNtGSVVZRzZStHuWGl5SMmqHSOCAlixU_Q2aF3iOHvDlKut2EXxy9SzSirpNRKsJFaHKgmhpQiuHqIvjPxuaakntzXk_t6cl9P7seD07fa3aoD-x9_l83_Ac4JgOA</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Ma, Chongyang</creator><creator>Liu, Shuling</creator><creator>Zhang, Shuang</creator><creator>Xu, Tian</creator><creator>Yu, Xue</creator><creator>Gao, Yushan</creator><creator>Zhai, Changming</creator><creator>Li, Changxiang</creator><creator>Lei, Chaofang</creator><creator>Fan, Shuning</creator><creator>Chen, Yuxi</creator><creator>Tian, Huiling</creator><creator>Wang, Qingguo</creator><creator>Cheng, Fafeng</creator><creator>Wang, Xueqian</creator><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20181201</creationdate><title>Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review)</title><author>Ma, Chongyang ; 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| source | Spandidos Publications Journals; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Apoptosis Biomarkers Cardiovascular disease Cytokines Edema Gene Expression Humans Inflammasomes - metabolism Inflammation Ischemia Molecular Targeted Therapy Multiprotein Complexes - chemistry Multiprotein Complexes - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Phosphorylation Proteins Rodents Signal Transduction Stroke - drug therapy Stroke - etiology Stroke - metabolism Stroke - pathology |
| title | Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review) |
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