Human leukocye antigen-G expression after heart transplantation is associated with a reduced incidence of rejection
BACKGROUND: Human leukocyte antigen (HLA)-G, a nonclassic major histocompatibility complex class I molecule expressed in the extravillous cytotrophoblast at the feto-maternal interface, is known to protect the fetus from maternal cellular immunity. In a preliminary study, we showed that HLA-G is exp...
Gespeichert in:
| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2002-04, Vol.105 (16), p.1949 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 16 |
| container_start_page | 1949 |
| container_title | Circulation (New York, N.Y.) |
| container_volume | 105 |
| creator | Nermine Lila Amrein, Catherine Guillemain, Romain Chevalier, Patrick |
| description | BACKGROUND: Human leukocyte antigen (HLA)-G, a nonclassic major histocompatibility complex class I molecule expressed in the extravillous cytotrophoblast at the feto-maternal interface, is known to protect the fetus from maternal cellular immunity. In a preliminary study, we showed that HLA-G is expressed in the hearts of some patients after heart transplantation. METHODS AND RESULTS: In the present study, a larger number of patients was investigated to confirm this finding and to look for possible correlations between HLA-G expression and the number and types of rejection. Expression of HLA-G in endomyocardial biopsy specimens was investigated by immunohistochemical analysis, and detection of the soluble HLA-G in the serum was performed by immunoprecipitation followed by Western blot analysis. HLA-G was detected in the biopsy specimens and serum of 9 of 51 patients (18%). The number of episodes of acute rejection was significantly lower in HLA-G-positive patients (1.2+/-1.1) as compared with HLA-G-negative patients (4.5+/-2.8) (P |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_212751047</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>118899951</sourcerecordid><originalsourceid>FETCH-proquest_journals_2127510473</originalsourceid><addsrcrecordid>eNqNi1sKwjAURIMoWB97uPhfaNPW4rf4WID_cklvNbUmNTdB3b0RXIBfw5kzMxJJXskyLatiMxZJlmWbtC6knIoZcxdxXdRVIvgY7migp3Cz6k2AxusLmfQA9BocMWtrAFtPDq6EzoN3aHjo4w7912kGZLZKo6cGntpfAcFRE1REbZRuyCgC28ayI_X9LMSkxZ5p-cu5WO13p-0xHZx9BGJ_7mxwJqqzzGVd5VlZF3-NPuZSTYg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>212751047</pqid></control><display><type>article</type><title>Human leukocye antigen-G expression after heart transplantation is associated with a reduced incidence of rejection</title><source>American Heart Association Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Journals@Ovid Complete</source><creator>Nermine Lila ; Amrein, Catherine ; Guillemain, Romain ; Chevalier, Patrick</creator><creatorcontrib>Nermine Lila ; Amrein, Catherine ; Guillemain, Romain ; Chevalier, Patrick</creatorcontrib><description>BACKGROUND: Human leukocyte antigen (HLA)-G, a nonclassic major histocompatibility complex class I molecule expressed in the extravillous cytotrophoblast at the feto-maternal interface, is known to protect the fetus from maternal cellular immunity. In a preliminary study, we showed that HLA-G is expressed in the hearts of some patients after heart transplantation. METHODS AND RESULTS: In the present study, a larger number of patients was investigated to confirm this finding and to look for possible correlations between HLA-G expression and the number and types of rejection. Expression of HLA-G in endomyocardial biopsy specimens was investigated by immunohistochemical analysis, and detection of the soluble HLA-G in the serum was performed by immunoprecipitation followed by Western blot analysis. HLA-G was detected in the biopsy specimens and serum of 9 of 51 patients (18%). The number of episodes of acute rejection was significantly lower in HLA-G-positive patients (1.2+/-1.1) as compared with HLA-G-negative patients (4.5+/-2.8) (P<0.001). No chronic rejection was observed in HLA-G-positive patients, whereas 15 HLA-G-negative patients had chronic rejection (P<0.032). A longitudinal study of these patients reveals that the status of HLA-G expression was maintained after 6 months both in serum and in biopsy specimens. During this period, HLA-G-positive patients did not have chronic rejection. CONCLUSIONS: There is a significant correlation between rejection and HLA-G expression in the heart after transplantation. HLA-G expression and its effect in reducing the incidence and severity of rejection seem to be stable throughout the evolution.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Baltimore: American Heart Association, Inc</publisher><ispartof>Circulation (New York, N.Y.), 2002-04, Vol.105 (16), p.1949</ispartof><rights>Copyright American Heart Association, Inc. Apr 23, 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>Nermine Lila</creatorcontrib><creatorcontrib>Amrein, Catherine</creatorcontrib><creatorcontrib>Guillemain, Romain</creatorcontrib><creatorcontrib>Chevalier, Patrick</creatorcontrib><title>Human leukocye antigen-G expression after heart transplantation is associated with a reduced incidence of rejection</title><title>Circulation (New York, N.Y.)</title><description>BACKGROUND: Human leukocyte antigen (HLA)-G, a nonclassic major histocompatibility complex class I molecule expressed in the extravillous cytotrophoblast at the feto-maternal interface, is known to protect the fetus from maternal cellular immunity. In a preliminary study, we showed that HLA-G is expressed in the hearts of some patients after heart transplantation. METHODS AND RESULTS: In the present study, a larger number of patients was investigated to confirm this finding and to look for possible correlations between HLA-G expression and the number and types of rejection. Expression of HLA-G in endomyocardial biopsy specimens was investigated by immunohistochemical analysis, and detection of the soluble HLA-G in the serum was performed by immunoprecipitation followed by Western blot analysis. HLA-G was detected in the biopsy specimens and serum of 9 of 51 patients (18%). The number of episodes of acute rejection was significantly lower in HLA-G-positive patients (1.2+/-1.1) as compared with HLA-G-negative patients (4.5+/-2.8) (P<0.001). No chronic rejection was observed in HLA-G-positive patients, whereas 15 HLA-G-negative patients had chronic rejection (P<0.032). A longitudinal study of these patients reveals that the status of HLA-G expression was maintained after 6 months both in serum and in biopsy specimens. During this period, HLA-G-positive patients did not have chronic rejection. CONCLUSIONS: There is a significant correlation between rejection and HLA-G expression in the heart after transplantation. HLA-G expression and its effect in reducing the incidence and severity of rejection seem to be stable throughout the evolution.</description><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqNi1sKwjAURIMoWB97uPhfaNPW4rf4WID_cklvNbUmNTdB3b0RXIBfw5kzMxJJXskyLatiMxZJlmWbtC6knIoZcxdxXdRVIvgY7migp3Cz6k2AxusLmfQA9BocMWtrAFtPDq6EzoN3aHjo4w7912kGZLZKo6cGntpfAcFRE1REbZRuyCgC28ayI_X9LMSkxZ5p-cu5WO13p-0xHZx9BGJ_7mxwJqqzzGVd5VlZF3-NPuZSTYg</recordid><startdate>20020423</startdate><enddate>20020423</enddate><creator>Nermine Lila</creator><creator>Amrein, Catherine</creator><creator>Guillemain, Romain</creator><creator>Chevalier, Patrick</creator><general>American Heart Association, Inc</general><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope></search><sort><creationdate>20020423</creationdate><title>Human leukocye antigen-G expression after heart transplantation is associated with a reduced incidence of rejection</title><author>Nermine Lila ; Amrein, Catherine ; Guillemain, Romain ; Chevalier, Patrick</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_2127510473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nermine Lila</creatorcontrib><creatorcontrib>Amrein, Catherine</creatorcontrib><creatorcontrib>Guillemain, Romain</creatorcontrib><creatorcontrib>Chevalier, Patrick</creatorcontrib><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nermine Lila</au><au>Amrein, Catherine</au><au>Guillemain, Romain</au><au>Chevalier, Patrick</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human leukocye antigen-G expression after heart transplantation is associated with a reduced incidence of rejection</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><date>2002-04-23</date><risdate>2002</risdate><volume>105</volume><issue>16</issue><spage>1949</spage><pages>1949-</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>BACKGROUND: Human leukocyte antigen (HLA)-G, a nonclassic major histocompatibility complex class I molecule expressed in the extravillous cytotrophoblast at the feto-maternal interface, is known to protect the fetus from maternal cellular immunity. In a preliminary study, we showed that HLA-G is expressed in the hearts of some patients after heart transplantation. METHODS AND RESULTS: In the present study, a larger number of patients was investigated to confirm this finding and to look for possible correlations between HLA-G expression and the number and types of rejection. Expression of HLA-G in endomyocardial biopsy specimens was investigated by immunohistochemical analysis, and detection of the soluble HLA-G in the serum was performed by immunoprecipitation followed by Western blot analysis. HLA-G was detected in the biopsy specimens and serum of 9 of 51 patients (18%). The number of episodes of acute rejection was significantly lower in HLA-G-positive patients (1.2+/-1.1) as compared with HLA-G-negative patients (4.5+/-2.8) (P<0.001). No chronic rejection was observed in HLA-G-positive patients, whereas 15 HLA-G-negative patients had chronic rejection (P<0.032). A longitudinal study of these patients reveals that the status of HLA-G expression was maintained after 6 months both in serum and in biopsy specimens. During this period, HLA-G-positive patients did not have chronic rejection. CONCLUSIONS: There is a significant correlation between rejection and HLA-G expression in the heart after transplantation. HLA-G expression and its effect in reducing the incidence and severity of rejection seem to be stable throughout the evolution.</abstract><cop>Baltimore</cop><pub>American Heart Association, Inc</pub></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 2002-04, Vol.105 (16), p.1949 |
| issn | 0009-7322 1524-4539 |
| language | eng |
| recordid | cdi_proquest_journals_212751047 |
| source | American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| title | Human leukocye antigen-G expression after heart transplantation is associated with a reduced incidence of rejection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T05%3A21%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Human%20leukocye%20antigen-G%20expression%20after%20heart%20transplantation%20is%20associated%20with%20a%20reduced%20incidence%20of%20rejection&rft.jtitle=Circulation%20(New%20York,%20N.Y.)&rft.au=Nermine%20Lila&rft.date=2002-04-23&rft.volume=105&rft.issue=16&rft.spage=1949&rft.pages=1949-&rft.issn=0009-7322&rft.eissn=1524-4539&rft.coden=CIRCAZ&rft_id=info:doi/&rft_dat=%3Cproquest%3E118899951%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=212751047&rft_id=info:pmid/&rfr_iscdi=true |