Dual-functional 3D-printed composite scaffold for inhibiting bacterial infection and promoting bone regeneration in infected bone defect models

[Display omitted] Infection is one of the pivotal causes of nonunion in large bone defect after trauma or tumor resection. Three-dimensional (3D) composite scaffold with multifunctional-therapeutic properties offer many advantages over allogenic or xenogenic bone grafting for the restoration of chal...

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Veröffentlicht in:	Acta biomaterialia 2018-10, Vol.79, p.265-275
Hauptverfasser:	Yang, Ying, Chu, Linyang, Yang, Shengbing, Zhang, Hongbo, Qin, Ling, Guillaume, Olivier, Eglin, David, Richards, R. Geoff, Tang, Tingting
Format:	Artikel
Sprache:	eng
Schlagworte:	3-D printers 3D printing Bacterial infections Biocompatibility Biodegradation Biofilms Biomedical materials Bone grafts Bone growth Bone regeneration Cancellous bone Chitosan Composite materials Computed tomography Cortical bone Defects Dual-functional Femur Grafting Hydroxyapatite In vivo methods and tests Infected bone defect Infections Maintenance Nonunion Osteoconduction Polylactic acid Polylactide-co-glycolide Quaternized chitosan Rabbits Regeneration Regeneration (physiology) Restoration Scaffolds Substitute bone Surgical implants Three dimensional composites Three dimensional printing Tissue engineering Transplants & implants Trauma Xenografts
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