Zinc-mediated reduction of apoptosis in cardiac allografts

BACKGROUND: Apoptosis is thought to occur during immune-mediated acute rejection of cardiac allografts. In vitro studies have shown that zinc inhibits the activity of the proapoptotic enzyme caspase-3. We hypothesized that ZnCl(2) would reduce acute cardiac rejection in vivo via the blockade of casp...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2000-11, Vol.102 (19), p.228-232
Hauptverfasser:	KOWN, Murray H, VAN DER STEENHOVEN, Tim, BLANKENBERG, Francis G, HOYT, Grant, BERRY, Gerald J, TAIT, Jonathan F, STRAUSS, H. William, ROBBINS, Robert C
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences General and cellular metabolism. Vitamins Medical sciences Pharmacology. Drug treatments
Online-Zugang:	Volltext
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