High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells: Role of protein kinase C and reactive oxygen species

Prostaglandins generated by cyclooxygenase (COX) have been implicated in hyperglycemia-induced endothelial dysfunction. However, the role of individual COX isoenzymes as well as the molecular mechanisms linking oxidative stress and endothelial dysfunction in diabetes remains to be clarified. Human a...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2003-02, Vol.107 (7), p.1017-1023
Hauptverfasser:	COSENTINO, Francesco, ETO, Masato, LÜSCHER, Thomas F, DE PAOLIS, Paola, VAN DER LOO, Bernd, BACHSCHMID, Markus, ULLRICH, Volker, KOUROEDOV, Alexei, DELLI GATTI, Chiara, JOCH, Hana, VOLPE, Massimo
Format:	Artikel
Sprache:	eng
Schlagworte:	Associated diseases and complications Biological and medical sciences Cells, Cultured Cyclooxygenase 2 Cytochrome P-450 Enzyme System - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Endothelium, Vascular - metabolism Epoprostenol - metabolism Gene Expression Regulation Glucose - pharmacology Humans Intramolecular Oxidoreductases - metabolism Isoenzymes - biosynthesis Isoenzymes - genetics Medical sciences Membrane Proteins Models, Biological NADPH Oxidases - metabolism Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III Oxidative Stress Prostaglandin-Endoperoxide Synthases - biosynthesis Prostaglandin-Endoperoxide Synthases - genetics Prostaglandins - metabolism Protein Kinase C - metabolism Reactive Oxygen Species - metabolism Signal Transduction Tetradecanoylphorbol Acetate - pharmacology Thromboxane A2 - biosynthesis Tyrosine - analogs & derivatives Tyrosine - analysis Up-Regulation
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