Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-α and angiotensin II

Tumor necrosis factor-alpha (TNF-alpha) and angiotensin II (Ang II) modulate heart failure in part by provoking the hypertrophic response. Signal transduction pathways of those factors are implicated in reactive oxygen intermediates (ROIs). Therefore, we hypothesized that TNF-alpha and Ang II might...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1998-08, Vol.98 (8), p.794-799
Hauptverfasser:	NAKAMURA, K, FUSHIMI, K, KOUCHI, H, MIHARA, K, MIYAZAKI, M, OHE, T, NAMBA, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - toxicity Animals Animals, Newborn Antioxidants - therapeutic use Biological and medical sciences Butylated Hydroxyanisole - therapeutic use Cardiology. Vascular system Cardiomegaly - chemically induced Cardiomegaly - drug therapy Catalase - therapeutic use Cells, Cultured Heart Heart failure, cardiogenic pulmonary edema, cardiac enlargement Leucine - metabolism Medical sciences Rats Rats, Wistar Reactive Oxygen Species - metabolism Recombinant Proteins - toxicity Tritium Tumor Necrosis Factor-alpha - toxicity Vitamin E - therapeutic use
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