Coronary restenosis after sirolimus-eluting stent implantation: Morphological description and mechanistic analysis from a consecutive series of cases
We describe the clinical and morphological patterns of restenosis after sirolimus-eluting stent (SES) implantation. From 121 patients with coronary angiography obtained >30 days after SES implantation, restenosis (diameter stenosis >50%) was identified in 19 patients and 20 lesions (located at...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2003-07, Vol.108 (3), p.257-260 |
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| creator | LEMOS, Pedro A SAIA, Francesco HOFMA, Sjoerd SMITS, Pieter C DE FEYTER, Pim VAN DER GIESSEN, Willem J VAN DOMBURG, Ron T SERRUYS, Patrick W LIGTHART, Jurgen M. R ARAMPATZIS, Chourmouzios A SIANOS, Georgios TANABE, Kengo HOYE, Angela DEGERTEKIN, Muzaffer DAEMEN, Joost MCFADDEN, Eugene |
| description | We describe the clinical and morphological patterns of restenosis after sirolimus-eluting stent (SES) implantation.
From 121 patients with coronary angiography obtained >30 days after SES implantation, restenosis (diameter stenosis >50%) was identified in 19 patients and 20 lesions (located at the proximal 5-mm segment in 30% or within the stent in 70%). Residual dissection after the procedure or balloon trauma outside the stent was identified in 83% of the proximal edge lesions. Lesions within the stent were focal, and stent discontinuity was identified in some lesions evaluated by intravascular ultrasound.
Sirolimus-eluting stent edge restenosis is frequently associated with local trauma outside the stent. In-stent restenosis occurs as a localized lesion, commonly associated with a discontinuity in stent coverage. Local conditions instead of intrinsic drug-resistance to sirolimus are likely to play a major role in post-SES restenosis. |
| doi_str_mv | 10.1161/01.CIR.0000083366.33686.11 |
| format | Article |
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From 121 patients with coronary angiography obtained >30 days after SES implantation, restenosis (diameter stenosis >50%) was identified in 19 patients and 20 lesions (located at the proximal 5-mm segment in 30% or within the stent in 70%). Residual dissection after the procedure or balloon trauma outside the stent was identified in 83% of the proximal edge lesions. Lesions within the stent were focal, and stent discontinuity was identified in some lesions evaluated by intravascular ultrasound.
Sirolimus-eluting stent edge restenosis is frequently associated with local trauma outside the stent. In-stent restenosis occurs as a localized lesion, commonly associated with a discontinuity in stent coverage. Local conditions instead of intrinsic drug-resistance to sirolimus are likely to play a major role in post-SES restenosis.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.0000083366.33686.11</identifier><identifier>PMID: 12860901</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; Angioplasty, Balloon, Coronary ; Biological and medical sciences ; Blood Vessel Prosthesis Implantation - adverse effects ; Coronary Angiography ; Coronary Restenosis - diagnosis ; Coronary Restenosis - etiology ; Diseases of the cardiovascular system ; Drug Implants - adverse effects ; Female ; Follow-Up Studies ; Humans ; Immunosuppressive Agents - adverse effects ; Male ; Medical sciences ; Middle Aged ; Postoperative Complications - diagnosis ; Postoperative Complications - etiology ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Registries ; Sirolimus - adverse effects ; Stents - adverse effects ; Treatment Outcome ; Ultrasonography, Interventional</subject><ispartof>Circulation (New York, N.Y.), 2003-07, Vol.108 (3), p.257-260</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Jul 22 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c356t-a8117b7072a1a10b19ee0b090ad2742585b4fa2670884d100d39b5d51880cb1f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15005761$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12860901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LEMOS, Pedro A</creatorcontrib><creatorcontrib>SAIA, Francesco</creatorcontrib><creatorcontrib>HOFMA, Sjoerd</creatorcontrib><creatorcontrib>SMITS, Pieter C</creatorcontrib><creatorcontrib>DE FEYTER, Pim</creatorcontrib><creatorcontrib>VAN DER GIESSEN, Willem J</creatorcontrib><creatorcontrib>VAN DOMBURG, Ron T</creatorcontrib><creatorcontrib>SERRUYS, Patrick W</creatorcontrib><creatorcontrib>LIGTHART, Jurgen M. R</creatorcontrib><creatorcontrib>ARAMPATZIS, Chourmouzios A</creatorcontrib><creatorcontrib>SIANOS, Georgios</creatorcontrib><creatorcontrib>TANABE, Kengo</creatorcontrib><creatorcontrib>HOYE, Angela</creatorcontrib><creatorcontrib>DEGERTEKIN, Muzaffer</creatorcontrib><creatorcontrib>DAEMEN, Joost</creatorcontrib><creatorcontrib>MCFADDEN, Eugene</creatorcontrib><title>Coronary restenosis after sirolimus-eluting stent implantation: Morphological description and mechanistic analysis from a consecutive series of cases</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>We describe the clinical and morphological patterns of restenosis after sirolimus-eluting stent (SES) implantation.
From 121 patients with coronary angiography obtained >30 days after SES implantation, restenosis (diameter stenosis >50%) was identified in 19 patients and 20 lesions (located at the proximal 5-mm segment in 30% or within the stent in 70%). Residual dissection after the procedure or balloon trauma outside the stent was identified in 83% of the proximal edge lesions. Lesions within the stent were focal, and stent discontinuity was identified in some lesions evaluated by intravascular ultrasound.
Sirolimus-eluting stent edge restenosis is frequently associated with local trauma outside the stent. In-stent restenosis occurs as a localized lesion, commonly associated with a discontinuity in stent coverage. Local conditions instead of intrinsic drug-resistance to sirolimus are likely to play a major role in post-SES restenosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Angioplasty, Balloon, Coronary</subject><subject>Biological and medical sciences</subject><subject>Blood Vessel Prosthesis Implantation - adverse effects</subject><subject>Coronary Angiography</subject><subject>Coronary Restenosis - diagnosis</subject><subject>Coronary Restenosis - etiology</subject><subject>Diseases of the cardiovascular system</subject><subject>Drug Implants - adverse effects</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Postoperative Complications - diagnosis</subject><subject>Postoperative Complications - etiology</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Registries</subject><subject>Sirolimus - adverse effects</subject><subject>Stents - adverse effects</subject><subject>Treatment Outcome</subject><subject>Ultrasonography, Interventional</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUV1r3DAQFKWluV77F4oI9NFXrWR9OG_lSJtASqG0z0KW5UTBtlytHcgP6f-t3BycHlYsMzvSzhByCewAoOAzg8Px9ueBbccIodShFKMK-IrsQPK6qqVoXpNdwZtKC84vyDvEx9IqoeVbcgHcKNYw2JG_x5TT5PIzzQGXMCWMSF2_hEwx5jTEccUqDOsSp3u6ERYax3lw0-KWmKYr-j3l-SEN6T56N9AuoM9x3iDqpo6OwT-4KeISfend8LzJ9zmN1FGfJgy-KD8FiiHHgDT11DsM-J686d2A4cPp3pPfX69_HW-qux_fbo9f7iovpFoqZwB0q5nmDhywFpoQWFsWcx3XNZdGtnXvuNLMmLoDxjrRtLKTYAzzLfRiTy5fdOec_qzFAPuY1lz-iZYD11w1xeA9uXoh-ZwQc-jtnONYLLPA7BaIZWBLIPYciP0fSAHL8MfTC2s7hu48ekqgED6dCA6Lg312k4945knGpFYg_gETupc3</recordid><startdate>20030722</startdate><enddate>20030722</enddate><creator>LEMOS, Pedro A</creator><creator>SAIA, Francesco</creator><creator>HOFMA, Sjoerd</creator><creator>SMITS, Pieter C</creator><creator>DE FEYTER, Pim</creator><creator>VAN DER GIESSEN, Willem J</creator><creator>VAN DOMBURG, Ron T</creator><creator>SERRUYS, Patrick W</creator><creator>LIGTHART, Jurgen M. 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Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Registries</topic><topic>Sirolimus - adverse effects</topic><topic>Stents - adverse effects</topic><topic>Treatment Outcome</topic><topic>Ultrasonography, Interventional</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEMOS, Pedro A</creatorcontrib><creatorcontrib>SAIA, Francesco</creatorcontrib><creatorcontrib>HOFMA, Sjoerd</creatorcontrib><creatorcontrib>SMITS, Pieter C</creatorcontrib><creatorcontrib>DE FEYTER, Pim</creatorcontrib><creatorcontrib>VAN DER GIESSEN, Willem J</creatorcontrib><creatorcontrib>VAN DOMBURG, Ron T</creatorcontrib><creatorcontrib>SERRUYS, Patrick W</creatorcontrib><creatorcontrib>LIGTHART, Jurgen M. 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R</au><au>ARAMPATZIS, Chourmouzios A</au><au>SIANOS, Georgios</au><au>TANABE, Kengo</au><au>HOYE, Angela</au><au>DEGERTEKIN, Muzaffer</au><au>DAEMEN, Joost</au><au>MCFADDEN, Eugene</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coronary restenosis after sirolimus-eluting stent implantation: Morphological description and mechanistic analysis from a consecutive series of cases</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2003-07-22</date><risdate>2003</risdate><volume>108</volume><issue>3</issue><spage>257</spage><epage>260</epage><pages>257-260</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>We describe the clinical and morphological patterns of restenosis after sirolimus-eluting stent (SES) implantation.
From 121 patients with coronary angiography obtained >30 days after SES implantation, restenosis (diameter stenosis >50%) was identified in 19 patients and 20 lesions (located at the proximal 5-mm segment in 30% or within the stent in 70%). Residual dissection after the procedure or balloon trauma outside the stent was identified in 83% of the proximal edge lesions. Lesions within the stent were focal, and stent discontinuity was identified in some lesions evaluated by intravascular ultrasound.
Sirolimus-eluting stent edge restenosis is frequently associated with local trauma outside the stent. In-stent restenosis occurs as a localized lesion, commonly associated with a discontinuity in stent coverage. Local conditions instead of intrinsic drug-resistance to sirolimus are likely to play a major role in post-SES restenosis.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>12860901</pmid><doi>10.1161/01.CIR.0000083366.33686.11</doi><tpages>4</tpages></addata></record> |
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| ispartof | Circulation (New York, N.Y.), 2003-07, Vol.108 (3), p.257-260 |
| issn | 0009-7322 1524-4539 |
| language | eng |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Adult Aged Angioplasty, Balloon, Coronary Biological and medical sciences Blood Vessel Prosthesis Implantation - adverse effects Coronary Angiography Coronary Restenosis - diagnosis Coronary Restenosis - etiology Diseases of the cardiovascular system Drug Implants - adverse effects Female Follow-Up Studies Humans Immunosuppressive Agents - adverse effects Male Medical sciences Middle Aged Postoperative Complications - diagnosis Postoperative Complications - etiology Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Registries Sirolimus - adverse effects Stents - adverse effects Treatment Outcome Ultrasonography, Interventional |
| title | Coronary restenosis after sirolimus-eluting stent implantation: Morphological description and mechanistic analysis from a consecutive series of cases |
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