Primary and Secondary Allergies to Laboratory Animals
Although laboratory animal allergy (LAA) is a significant occupational hazard among workers exposed to laboratory animalsy few studie have evaluated long-term risks to workers who remain in the workplace. This short-term focus has obscured the evaluation of subsequent animal allergies (secondary LAA...
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| Veröffentlicht in: | Journal of occupational and environmental medicine 2002-12, Vol.44 (12), p.1143-1152 |
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| container_title | Journal of occupational and environmental medicine |
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| creator | Goodno, Leslie E. Stave, Gregg M. |
| description | Although laboratory animal allergy (LAA) is a significant occupational hazard among workers exposed to laboratory animalsy few studie have evaluated long-term risks to workers who remain in the workplace. This short-term focus has obscured the evaluation of subsequent animal allergies (secondary LAA). We analyzed surveillance data from a 10-year LAA prevention program to estimate incidence rates of primary and secondary LAA and to evaluate the effectiveness of the prevention program in reducing the development of primary LAA. The 10-year incidence rates of primary and secondary LAA were 1.34 (95% CI, 0.78-1.90) and 11 (95% CI, 7.4-14.6) cases per 100 person-years, respectively. The annual incidence of primary LAA was reduced from 3.6% to 0 in the first 5 years and did not rise above 1.2% over the remaining years, whereas the incidence of secondary LAA was greater than 8% in most years. These findings suggest that programs effective at preventing primary LAA may need to be evaluated for their effectiveness at protecting against further risk. |
| doi_str_mv | 10.1097/00043764-200212000-00008 |
| format | Article |
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This short-term focus has obscured the evaluation of subsequent animal allergies (secondary LAA). We analyzed surveillance data from a 10-year LAA prevention program to estimate incidence rates of primary and secondary LAA and to evaluate the effectiveness of the prevention program in reducing the development of primary LAA. The 10-year incidence rates of primary and secondary LAA were 1.34 (95% CI, 0.78-1.90) and 11 (95% CI, 7.4-14.6) cases per 100 person-years, respectively. The annual incidence of primary LAA was reduced from 3.6% to 0 in the first 5 years and did not rise above 1.2% over the remaining years, whereas the incidence of secondary LAA was greater than 8% in most years. 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This short-term focus has obscured the evaluation of subsequent animal allergies (secondary LAA). We analyzed surveillance data from a 10-year LAA prevention program to estimate incidence rates of primary and secondary LAA and to evaluate the effectiveness of the prevention program in reducing the development of primary LAA. The 10-year incidence rates of primary and secondary LAA were 1.34 (95% CI, 0.78-1.90) and 11 (95% CI, 7.4-14.6) cases per 100 person-years, respectively. The annual incidence of primary LAA was reduced from 3.6% to 0 in the first 5 years and did not rise above 1.2% over the remaining years, whereas the incidence of secondary LAA was greater than 8% in most years. These findings suggest that programs effective at preventing primary LAA may need to be evaluated for their effectiveness at protecting against further risk.</description><subject>Adult</subject><subject>Allergic diseases</subject><subject>Allergies</subject><subject>Animal Technicians</subject><subject>Animals</subject><subject>Animals, Laboratory - immunology</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity - etiology</subject><subject>Hypersensitivity - prevention & control</subject><subject>Immunopathology</subject><subject>Incidence</subject><subject>Laboratory animals</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>North Carolina - epidemiology</subject><subject>Occupational Diseases - etiology</subject><subject>Occupational Diseases - prevention & control</subject><subject>Occupational hazards</subject><subject>ORIGINAL ARTICLES</subject><subject>Other localizations</subject><subject>Population Surveillance</subject><subject>Risk Factors</subject><issn>1076-2752</issn><issn>1536-5948</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctOwzAQRS0E4lH4BFCExDIwfjtLhHhJlUAC1pYTO7QlTYqdquLvmZJCVyzs8VjnzniuCckoXFIo9BUACK6VyBkAo7hBjgvMDjmkkqtcFsLs4hm0ypmW7IAcpTQDoJKC3CcHlEmsINUhkc9xOnfxK3Otz15C1bV-nV03TYjv05CyvsvGruyi67v1fYt0k47JXo0hnGziiLzd3b7ePOTjp_vHm-txXgkuTR7AYROgHvBBJSa-FgxUpVioveEcKl_JUkDJQYIPwRludM0U01Q470s-IudD3UXsPpch9XbWLWOLLS2OrQqjuEHIDFAVu5RiqO1imMlSsGu77K9d9s8u-2MXSs829ZflPPitcOMPAhcbwKXKNXV0bTVNW04IobkQyImBW3VNH2L6aJarEO0kuKaf2P--C2Wng2yW0N6_skIUhdEa-DdGtYlT</recordid><startdate>200212</startdate><enddate>200212</enddate><creator>Goodno, Leslie E.</creator><creator>Stave, Gregg M.</creator><general>Lippincott Williams & Wilkins</general><general>The American College of Occupational and Environmental Medicine</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope></search><sort><creationdate>200212</creationdate><title>Primary and Secondary Allergies to Laboratory Animals</title><author>Goodno, Leslie E. ; Stave, Gregg M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4358-e0a45601d0594b0a4df4206c62efd8330cdc5b40b3050deea8387f262714addb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Allergic diseases</topic><topic>Allergies</topic><topic>Animal Technicians</topic><topic>Animals</topic><topic>Animals, Laboratory - immunology</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Humans</topic><topic>Hypersensitivity - etiology</topic><topic>Hypersensitivity - prevention & control</topic><topic>Immunopathology</topic><topic>Incidence</topic><topic>Laboratory animals</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>North Carolina - epidemiology</topic><topic>Occupational Diseases - etiology</topic><topic>Occupational Diseases - prevention & control</topic><topic>Occupational hazards</topic><topic>ORIGINAL ARTICLES</topic><topic>Other localizations</topic><topic>Population Surveillance</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goodno, Leslie E.</creatorcontrib><creatorcontrib>Stave, Gregg M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Journal of occupational and environmental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goodno, Leslie E.</au><au>Stave, Gregg M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary and Secondary Allergies to Laboratory Animals</atitle><jtitle>Journal of occupational and environmental medicine</jtitle><addtitle>J Occup Environ Med</addtitle><date>2002-12</date><risdate>2002</risdate><volume>44</volume><issue>12</issue><spage>1143</spage><epage>1152</epage><pages>1143-1152</pages><issn>1076-2752</issn><eissn>1536-5948</eissn><coden>JOEMFM</coden><abstract>Although laboratory animal allergy (LAA) is a significant occupational hazard among workers exposed to laboratory animalsy few studie have evaluated long-term risks to workers who remain in the workplace. This short-term focus has obscured the evaluation of subsequent animal allergies (secondary LAA). We analyzed surveillance data from a 10-year LAA prevention program to estimate incidence rates of primary and secondary LAA and to evaluate the effectiveness of the prevention program in reducing the development of primary LAA. The 10-year incidence rates of primary and secondary LAA were 1.34 (95% CI, 0.78-1.90) and 11 (95% CI, 7.4-14.6) cases per 100 person-years, respectively. The annual incidence of primary LAA was reduced from 3.6% to 0 in the first 5 years and did not rise above 1.2% over the remaining years, whereas the incidence of secondary LAA was greater than 8% in most years. These findings suggest that programs effective at preventing primary LAA may need to be evaluated for their effectiveness at protecting against further risk.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>12500456</pmid><doi>10.1097/00043764-200212000-00008</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of occupational and environmental medicine, 2002-12, Vol.44 (12), p.1143-1152 |
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| source | MEDLINE; Journals@Ovid Complete; JSTOR Archive Collection A-Z Listing |
| subjects | Adult Allergic diseases Allergies Animal Technicians Animals Animals, Laboratory - immunology Biological and medical sciences Female Humans Hypersensitivity - etiology Hypersensitivity - prevention & control Immunopathology Incidence Laboratory animals Male Medical sciences Middle Aged North Carolina - epidemiology Occupational Diseases - etiology Occupational Diseases - prevention & control Occupational hazards ORIGINAL ARTICLES Other localizations Population Surveillance Risk Factors |
| title | Primary and Secondary Allergies to Laboratory Animals |
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