Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway

NO-induced dilations in resistance arteries (RAs) are not associated with decreases in vascular smooth muscle cell Ca2+. We tested whether a cGMP-dependent activation of the smooth muscle myosin light chain phosphatase (MLCP) resulting in a Ca2+ desensitization of the contractile apparatus was the u...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2003-06, Vol.107 (24), p.3081-3087
Hauptverfasser:	BOLZ, Steffen-Sebastian, VOGEL, Lukas, SOLLINGER, Daniel, DERWAND, Roland, DE WIT, Cor, LOIRAND, Gervaise, POHL, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP Ribose Transferases - biosynthesis ADP Ribose Transferases - genetics ADP Ribose Transferases - pharmacology Animals Arteries - drug effects Arteries - physiology Biological and medical sciences Blood vessels and receptors Botulinum Toxins - biosynthesis Botulinum Toxins - genetics Botulinum Toxins - pharmacology Calcium - pharmacology Cricetinae Cyclic GMP - metabolism Enzyme Inhibitors - pharmacology Female Fundamental and applied biological sciences. Psychology In Vitro Techniques Intracellular Signaling Peptides and Proteins Lysophospholipids Muscles - blood supply Mutagenesis, Site-Directed Myosin-Light-Chain Phosphatase Nitric Oxide - pharmacology Phosphoprotein Phosphatases - antagonists & inhibitors Phosphoprotein Phosphatases - metabolism Protein-Serine-Threonine Kinases - drug effects Protein-Serine-Threonine Kinases - metabolism rho-Associated Kinases rhoA GTP-Binding Protein - drug effects rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism Signal Transduction - drug effects Signal Transduction - physiology Sphingosine - analogs & derivatives Sphingosine - pharmacology Transfection Vascular Patency - drug effects Vascular Patency - physiology Vascular Resistance - drug effects Vascular Resistance - physiology Vasoconstriction - drug effects Vasoconstriction - physiology Vasoconstrictor Agents - pharmacology Vasodilator Agents - pharmacology Vertebrates: cardiovascular system
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