Toxicity of silver nanoparticles on different tissues of Balb/C mice
The main purpose of the current study was to evaluate the toxicity of silver nanoparticles (Ag NPs) on adult Balb/C mice. Twenty five Balb/C mice purchased and divided into four groups of five. Group one serves as control and injected by normal saline; group's two to four were injected by Ag NP...
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| Veröffentlicht in: | Life sciences (1973) 2018-10, Vol.211, p.81-90 |
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| container_title | Life sciences (1973) |
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| creator | Moradi-Sardareh, Hemen Basir, Hamid Reza Ghasemi Hassan, Zuhair Mohammad Davoudi, Maryam Amidi, Fardin Paknejad, Maliheh |
| description | The main purpose of the current study was to evaluate the toxicity of silver nanoparticles (Ag NPs) on adult Balb/C mice.
Twenty five Balb/C mice purchased and divided into four groups of five. Group one serves as control and injected by normal saline; group's two to four were injected by Ag NPs at 0.25, 0.50 and 1 mg/kg, respectively.
Overall, current results indicate that all concentration of Ag NPs have potential for induction of toxicity in different tissues. Ag NPs at concentration >0.25 mg/kg result in pathological changes in liver, spleen, brain, heart, lungs, kidneys, and testicles tissues; as well as it lead to significant change in sperm quality and quantity, and blood brain barrier (BBB) permeability. Ag NPs at the lowest concentration (0.25 mg/kg) significantly changed the oxidative stress levels in serum and liver tissue but did not change the level of liver enzymes and renal markers in serum.
The current research results support clearly the toxic effects of Ag NPs at very low concentration and suggest that further in vivo investigation are required to be able to confirm the safety of nanoparticle derived application to use in life. |
| doi_str_mv | 10.1016/j.lfs.2018.09.001 |
| format | Article |
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Twenty five Balb/C mice purchased and divided into four groups of five. Group one serves as control and injected by normal saline; group's two to four were injected by Ag NPs at 0.25, 0.50 and 1 mg/kg, respectively.
Overall, current results indicate that all concentration of Ag NPs have potential for induction of toxicity in different tissues. Ag NPs at concentration >0.25 mg/kg result in pathological changes in liver, spleen, brain, heart, lungs, kidneys, and testicles tissues; as well as it lead to significant change in sperm quality and quantity, and blood brain barrier (BBB) permeability. Ag NPs at the lowest concentration (0.25 mg/kg) significantly changed the oxidative stress levels in serum and liver tissue but did not change the level of liver enzymes and renal markers in serum.
The current research results support clearly the toxic effects of Ag NPs at very low concentration and suggest that further in vivo investigation are required to be able to confirm the safety of nanoparticle derived application to use in life.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2018.09.001</identifier><identifier>PMID: 30189219</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Antioxidants - metabolism ; Balb/C ; Biocompatibility ; Biomarkers - metabolism ; Blood brain barrier ; Blood-Brain Barrier - drug effects ; Brain ; Heart ; In vivo methods and tests ; Kidneys ; Liver ; Lungs ; Male ; Membrane permeability ; Metal Nanoparticles - toxicity ; Mice ; Mice, Inbred BALB C ; Nanoparticles ; Oxidative stress ; Oxidative Stress - drug effects ; Permeability ; Silver ; Silver - pharmacokinetics ; Silver - toxicity ; Silver nanoparticles ; Sperm ; Spermatozoa - drug effects ; Spermatozoa - pathology ; Spleen ; Tissue Distribution ; Tissues ; Toxicity</subject><ispartof>Life sciences (1973), 2018-10, Vol.211, p.81-90</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier BV Oct 15, 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-8e99038abe446688afd15cf3ab698de0a93d9a834c34b2c9ce1b6ee51fa9ee743</citedby><cites>FETCH-LOGICAL-c381t-8e99038abe446688afd15cf3ab698de0a93d9a834c34b2c9ce1b6ee51fa9ee743</cites><orcidid>0000-0002-1048-1237 ; 0000-0002-5522-4445</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lfs.2018.09.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30189219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moradi-Sardareh, Hemen</creatorcontrib><creatorcontrib>Basir, Hamid Reza Ghasemi</creatorcontrib><creatorcontrib>Hassan, Zuhair Mohammad</creatorcontrib><creatorcontrib>Davoudi, Maryam</creatorcontrib><creatorcontrib>Amidi, Fardin</creatorcontrib><creatorcontrib>Paknejad, Maliheh</creatorcontrib><title>Toxicity of silver nanoparticles on different tissues of Balb/C mice</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>The main purpose of the current study was to evaluate the toxicity of silver nanoparticles (Ag NPs) on adult Balb/C mice.
Twenty five Balb/C mice purchased and divided into four groups of five. Group one serves as control and injected by normal saline; group's two to four were injected by Ag NPs at 0.25, 0.50 and 1 mg/kg, respectively.
Overall, current results indicate that all concentration of Ag NPs have potential for induction of toxicity in different tissues. Ag NPs at concentration >0.25 mg/kg result in pathological changes in liver, spleen, brain, heart, lungs, kidneys, and testicles tissues; as well as it lead to significant change in sperm quality and quantity, and blood brain barrier (BBB) permeability. Ag NPs at the lowest concentration (0.25 mg/kg) significantly changed the oxidative stress levels in serum and liver tissue but did not change the level of liver enzymes and renal markers in serum.
The current research results support clearly the toxic effects of Ag NPs at very low concentration and suggest that further in vivo investigation are required to be able to confirm the safety of nanoparticle derived application to use in life.</description><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Balb/C</subject><subject>Biocompatibility</subject><subject>Biomarkers - metabolism</subject><subject>Blood brain barrier</subject><subject>Blood-Brain Barrier - drug effects</subject><subject>Brain</subject><subject>Heart</subject><subject>In vivo methods and tests</subject><subject>Kidneys</subject><subject>Liver</subject><subject>Lungs</subject><subject>Male</subject><subject>Membrane permeability</subject><subject>Metal Nanoparticles - toxicity</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Nanoparticles</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Permeability</subject><subject>Silver</subject><subject>Silver - pharmacokinetics</subject><subject>Silver - toxicity</subject><subject>Silver nanoparticles</subject><subject>Sperm</subject><subject>Spermatozoa - drug effects</subject><subject>Spermatozoa - pathology</subject><subject>Spleen</subject><subject>Tissue Distribution</subject><subject>Tissues</subject><subject>Toxicity</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OwzAQhC0EoqXwAFyQJc5J13GS2uIE5VeqxKWcLcdZS47SpNhpRd8elxaOnFZazczufIRcM0gZsHLapK0NaQZMpCBTAHZCxkzMZAIlZ6dkDJDlCc-gGJGLEBoAKIoZPycjHi0yY3JMHpf9lzNu2NHe0uDaLXra6a5faz8402KgfUdrZy167AY6uBA2-6WlD7qtpnO6cgYvyZnVbcCr45yQj-en5fw1Wby_vM3vF4nhgg2JQCmBC11hnpelENrWrDCW66qUokbQktdSC54bnleZkQZZVSIWzGqJOMv5hNwecte-_4xvDKrpN76LJ1XGslhtVgCLKnZQGd-H4NGqtXcr7XeKgdpzU42K3NSemwKp4Mdzc0zeVCus_xy_oKLg7iDA2G_r0KtgHHYGa-fRDKru3T_x30JLfYg</recordid><startdate>20181015</startdate><enddate>20181015</enddate><creator>Moradi-Sardareh, Hemen</creator><creator>Basir, Hamid Reza Ghasemi</creator><creator>Hassan, Zuhair Mohammad</creator><creator>Davoudi, Maryam</creator><creator>Amidi, Fardin</creator><creator>Paknejad, Maliheh</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0002-1048-1237</orcidid><orcidid>https://orcid.org/0000-0002-5522-4445</orcidid></search><sort><creationdate>20181015</creationdate><title>Toxicity of silver nanoparticles on different tissues of Balb/C mice</title><author>Moradi-Sardareh, Hemen ; Basir, Hamid Reza Ghasemi ; Hassan, Zuhair Mohammad ; Davoudi, Maryam ; Amidi, Fardin ; Paknejad, Maliheh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-8e99038abe446688afd15cf3ab698de0a93d9a834c34b2c9ce1b6ee51fa9ee743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Antioxidants - metabolism</topic><topic>Balb/C</topic><topic>Biocompatibility</topic><topic>Biomarkers - metabolism</topic><topic>Blood brain barrier</topic><topic>Blood-Brain Barrier - drug effects</topic><topic>Brain</topic><topic>Heart</topic><topic>In vivo methods and tests</topic><topic>Kidneys</topic><topic>Liver</topic><topic>Lungs</topic><topic>Male</topic><topic>Membrane permeability</topic><topic>Metal Nanoparticles - toxicity</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Nanoparticles</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Permeability</topic><topic>Silver</topic><topic>Silver - pharmacokinetics</topic><topic>Silver - toxicity</topic><topic>Silver nanoparticles</topic><topic>Sperm</topic><topic>Spermatozoa - drug effects</topic><topic>Spermatozoa - pathology</topic><topic>Spleen</topic><topic>Tissue Distribution</topic><topic>Tissues</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moradi-Sardareh, Hemen</creatorcontrib><creatorcontrib>Basir, Hamid Reza Ghasemi</creatorcontrib><creatorcontrib>Hassan, Zuhair Mohammad</creatorcontrib><creatorcontrib>Davoudi, Maryam</creatorcontrib><creatorcontrib>Amidi, Fardin</creatorcontrib><creatorcontrib>Paknejad, Maliheh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moradi-Sardareh, Hemen</au><au>Basir, Hamid Reza Ghasemi</au><au>Hassan, Zuhair Mohammad</au><au>Davoudi, Maryam</au><au>Amidi, Fardin</au><au>Paknejad, Maliheh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxicity of silver nanoparticles on different tissues of Balb/C mice</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2018-10-15</date><risdate>2018</risdate><volume>211</volume><spage>81</spage><epage>90</epage><pages>81-90</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>The main purpose of the current study was to evaluate the toxicity of silver nanoparticles (Ag NPs) on adult Balb/C mice.
Twenty five Balb/C mice purchased and divided into four groups of five. Group one serves as control and injected by normal saline; group's two to four were injected by Ag NPs at 0.25, 0.50 and 1 mg/kg, respectively.
Overall, current results indicate that all concentration of Ag NPs have potential for induction of toxicity in different tissues. Ag NPs at concentration >0.25 mg/kg result in pathological changes in liver, spleen, brain, heart, lungs, kidneys, and testicles tissues; as well as it lead to significant change in sperm quality and quantity, and blood brain barrier (BBB) permeability. Ag NPs at the lowest concentration (0.25 mg/kg) significantly changed the oxidative stress levels in serum and liver tissue but did not change the level of liver enzymes and renal markers in serum.
The current research results support clearly the toxic effects of Ag NPs at very low concentration and suggest that further in vivo investigation are required to be able to confirm the safety of nanoparticle derived application to use in life.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>30189219</pmid><doi>10.1016/j.lfs.2018.09.001</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-1048-1237</orcidid><orcidid>https://orcid.org/0000-0002-5522-4445</orcidid></addata></record> |
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| subjects | Animals Antioxidants - metabolism Balb/C Biocompatibility Biomarkers - metabolism Blood brain barrier Blood-Brain Barrier - drug effects Brain Heart In vivo methods and tests Kidneys Liver Lungs Male Membrane permeability Metal Nanoparticles - toxicity Mice Mice, Inbred BALB C Nanoparticles Oxidative stress Oxidative Stress - drug effects Permeability Silver Silver - pharmacokinetics Silver - toxicity Silver nanoparticles Sperm Spermatozoa - drug effects Spermatozoa - pathology Spleen Tissue Distribution Tissues Toxicity |
| title | Toxicity of silver nanoparticles on different tissues of Balb/C mice |
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