Technical and Clinical Performance of a New Assay to Detect Squamous Cell Carcinoma Antigen Levels for the Differential Diagnosis of Cervical, Lung, and Head and Neck Cancer
鳞状上皮细胞癌抗原水平在鳞状上皮细胞癌中通常升高。这项多中心研究评估了一种新的Elecsys®鳞状上皮细胞癌检测的检测性能，该检测方法是以等摩尔方式测量血清鳞状上皮细胞癌抗原1和2的水平，并研究了鳞状上皮细胞癌抗原用于宫颈癌、肺癌和头颈部鳞状上皮细胞癌鉴别诊断的潜能。在欧洲三个研究中心进行了精确度和方法学比较实验。健康人群的参考区间使用来自欧洲和中国人群的样本确定的。鉴别诊断试验确定了鳞状上皮细胞癌抗原水平能否将宫颈癌、肺癌或头颈癌与表观健康的、良性的或其他恶性群组区分开来。根据95%特异性下的鳞状上皮细胞癌抗原水平计算出鳞状上皮细胞癌抗原医学截断值。9个分析浓度的重复性变异系数...
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| creator | HOLDENRIEDER, Stefan MOLINA, Rafael QIU, Ling Xiuyi ZHI RUTZ, Sandra ENGEL, Christine KASPER-SAUER, Pia DAYYANI, Farshid Mkorse, Catharina |
| description | 鳞状上皮细胞癌抗原水平在鳞状上皮细胞癌中通常升高。这项多中心研究评估了一种新的Elecsys®鳞状上皮细胞癌检测的检测性能，该检测方法是以等摩尔方式测量血清鳞状上皮细胞癌抗原1和2的水平，并研究了鳞状上皮细胞癌抗原用于宫颈癌、肺癌和头颈部鳞状上皮细胞癌鉴别诊断的潜能。在欧洲三个研究中心进行了精确度和方法学比较实验。健康人群的参考区间使用来自欧洲和中国人群的样本确定的。鉴别诊断试验确定了鳞状上皮细胞癌抗原水平能否将宫颈癌、肺癌或头颈癌与表观健康的、良性的或其他恶性群组区分开来。根据95%特异性下的鳞状上皮细胞癌抗原水平计算出鳞状上皮细胞癌抗原医学截断值。9个分析浓度的重复性变异系数 |
| doi_str_mv | 10.3779/j.issn.1009-3419.2018.07.12 |
| format | Article |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Antigens Biomarkers Cancer therapies Cervical cancer Head & neck cancer Hospitals Human papillomavirus Laboratories Lung cancer Medical prognosis |
| title | Technical and Clinical Performance of a New Assay to Detect Squamous Cell Carcinoma Antigen Levels for the Differential Diagnosis of Cervical, Lung, and Head and Neck Cancer |
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