A feedback model for leukemia including cell competition and the action of the immune system

A feedback model for leukemia including cell competition and the action of the immune system

A mathematical model, coupling the dynamics of short-term stem-like cells and mature leukocytes in leukemia with that of the immune system, is investigated. The model is described by a system of nine delay differential equations with nine delays. Three equilibrium points E0, E1, E2 are highlighted....

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Hauptverfasser: Balea, S, Halanay, A, Neamtu, M
Format: Tagungsbericht
Sprache:eng
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Differential equations
Hopf bifurcation
Immune system
Leukemia
Leukocytes
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Halanay, A
Neamtu, M
description A mathematical model, coupling the dynamics of short-term stem-like cells and mature leukocytes in leukemia with that of the immune system, is investigated. The model is described by a system of nine delay differential equations with nine delays. Three equilibrium points E0, E1, E2 are highlighted. The stability and the existence of the Hopf bifurcation for the equilibrium points are investigated. In the analysis of the model, the rate of asymmetric division and the rate of symmetric division are very important.
doi_str_mv 10.1063/1.4907297
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source AIP Scitation Journals Complete
subjects Differential equations
Hopf bifurcation
Immune system
Leukemia
Leukocytes
title A feedback model for leukemia including cell competition and the action of the immune system
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