Breast cancer-derived M543V mutation in helix 12 of estrogen receptor [alpha] inverts response to estrogen and SERMs

We have isolated from human breast cancers several mutations in the Helix 12 component of activation function 2 (AF-2) in the estrogen receptor alpha (ERα). We used a novel approach to detect changes in the hormone-binding domain of ERα, based on the evidence that antiestrogens, such as 4-hydroxytam...

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Veröffentlicht in:	Breast cancer research and treatment 2010-04, Vol.120 (3), p.761
Hauptverfasser:	Nichols, Mark, Cheng, Peng, Liu, Yue, Kanterewicz, Beatriz, Hershberger, Pamela A, Mccarty, Kenneth S
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Cancer research Cancer therapies Estrogens Mutation
Online-Zugang:	Volltext
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