Optimization of Brownian ratchets for the manipulation of charged components within supported lipid bilayers
In probability theory, there is a counter-intuitive result that it is possible to construct a winning strategy from two individually losing (or at most breaking-even) “games” by alternating between them. The work presented here demonstrates the application of this principle to supported lipid bilaye...
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| Veröffentlicht in: | Applied physics letters 2015-05, Vol.106 (18) |
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| container_title | Applied physics letters |
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| creator | Roth, J. S. Zhang, Y. Bao, P. Cheetham, M. R. Han, X. Evans, S. D. |
| description | In probability theory, there is a counter-intuitive result that it is possible to construct a winning strategy from two individually losing (or at most breaking-even) “games” by alternating between them. The work presented here demonstrates the application of this principle to supported lipid bilayers (SLBs) in order to create directed motion of charged lipid components in the membrane, which was achieved through the use of “Brownian ratchets” in patterned SLBs. Both a finite element analysis model and an experimental setup have been used to investigate the role of key parameters for the operation of these ratchets: (1) the asymmetry of the ratchet teeth and (2) the relation of the ratchet height to the period of the applied electric field. Importantly, we find that the efficiency of the ratchet for a given charged species is dependent on the diffusion coefficient. This opens the possibility for separation of membrane species according to their size or viscous drag coefficient within the membrane. |
| doi_str_mv | 10.1063/1.4919801 |
| format | Article |
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S. ; Zhang, Y. ; Bao, P. ; Cheetham, M. R. ; Han, X. ; Evans, S. D.</creator><creatorcontrib>Roth, J. S. ; Zhang, Y. ; Bao, P. ; Cheetham, M. R. ; Han, X. ; Evans, S. D.</creatorcontrib><description>In probability theory, there is a counter-intuitive result that it is possible to construct a winning strategy from two individually losing (or at most breaking-even) “games” by alternating between them. The work presented here demonstrates the application of this principle to supported lipid bilayers (SLBs) in order to create directed motion of charged lipid components in the membrane, which was achieved through the use of “Brownian ratchets” in patterned SLBs. Both a finite element analysis model and an experimental setup have been used to investigate the role of key parameters for the operation of these ratchets: (1) the asymmetry of the ratchet teeth and (2) the relation of the ratchet height to the period of the applied electric field. Importantly, we find that the efficiency of the ratchet for a given charged species is dependent on the diffusion coefficient. This opens the possibility for separation of membrane species according to their size or viscous drag coefficient within the membrane.</description><identifier>ISSN: 0003-6951</identifier><identifier>EISSN: 1077-3118</identifier><identifier>DOI: 10.1063/1.4919801</identifier><language>eng</language><publisher>Melville: American Institute of Physics</publisher><subject>Applied physics ; Diffusion coefficient ; Drag coefficients ; Finite element method ; Game theory ; Lipids ; Probability theory ; Viscous drag</subject><ispartof>Applied physics letters, 2015-05, Vol.106 (18)</ispartof><rights>2015 AIP Publishing LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-eb619b7c2e2179f926942f245c5241720f3f8d0df3748f4a82f5650ee7bcef2f3</citedby><cites>FETCH-LOGICAL-c358t-eb619b7c2e2179f926942f245c5241720f3f8d0df3748f4a82f5650ee7bcef2f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Roth, J. 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Both a finite element analysis model and an experimental setup have been used to investigate the role of key parameters for the operation of these ratchets: (1) the asymmetry of the ratchet teeth and (2) the relation of the ratchet height to the period of the applied electric field. Importantly, we find that the efficiency of the ratchet for a given charged species is dependent on the diffusion coefficient. This opens the possibility for separation of membrane species according to their size or viscous drag coefficient within the membrane.</description><subject>Applied physics</subject><subject>Diffusion coefficient</subject><subject>Drag coefficients</subject><subject>Finite element method</subject><subject>Game theory</subject><subject>Lipids</subject><subject>Probability theory</subject><subject>Viscous drag</subject><issn>0003-6951</issn><issn>1077-3118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNo9kEtLxDAAhIMouK4e_AcBTx665tm0R118wcJe9FzSNLFZ2iQmKcv6663s4mkY5mMGBoBbjFYYlfQBr1iN6wrhM7DASIiCYlydgwVCiBZlzfEluEppN1tOKF2AYRuyHe2PzNY76A18in7vrHQwyqx6nRM0PsLcazhKZ8M0_JOql_FLd1D5MXin3Yzube6tg2kKwcc8Z4MNtoOtHeRBx3QNLowckr456RJ8vjx_rN-Kzfb1ff24KRTlVS50W-K6FYpogkVtalLWjBjCuOKEYUGQoabqUGeoYJVhsiKGlxxpLVqlDTF0Ce6OvSH670mn3Oz8FN082RBMmCgZ4nym7o-Uij6lqE0Toh1lPDQYNX9nNrg5nUl_AVKbaBo</recordid><startdate>20150504</startdate><enddate>20150504</enddate><creator>Roth, J. 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D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-eb619b7c2e2179f926942f245c5241720f3f8d0df3748f4a82f5650ee7bcef2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Applied physics</topic><topic>Diffusion coefficient</topic><topic>Drag coefficients</topic><topic>Finite element method</topic><topic>Game theory</topic><topic>Lipids</topic><topic>Probability theory</topic><topic>Viscous drag</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roth, J. S.</creatorcontrib><creatorcontrib>Zhang, Y.</creatorcontrib><creatorcontrib>Bao, P.</creatorcontrib><creatorcontrib>Cheetham, M. R.</creatorcontrib><creatorcontrib>Han, X.</creatorcontrib><creatorcontrib>Evans, S. 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Both a finite element analysis model and an experimental setup have been used to investigate the role of key parameters for the operation of these ratchets: (1) the asymmetry of the ratchet teeth and (2) the relation of the ratchet height to the period of the applied electric field. Importantly, we find that the efficiency of the ratchet for a given charged species is dependent on the diffusion coefficient. This opens the possibility for separation of membrane species according to their size or viscous drag coefficient within the membrane.</abstract><cop>Melville</cop><pub>American Institute of Physics</pub><doi>10.1063/1.4919801</doi><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | AIP Journals Complete; Alma/SFX Local Collection |
| subjects | Applied physics Diffusion coefficient Drag coefficients Finite element method Game theory Lipids Probability theory Viscous drag |
| title | Optimization of Brownian ratchets for the manipulation of charged components within supported lipid bilayers |
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