Encapsulation of chlorine-containing carbamates in polypeptide nanoparticles prepared by enzymatic hydrolysis of casein
Encapsulation of biologically active β-oxalylamino substituted O -ethylcarbamate in micelles of non-hydrolyzed and hydrolyzed casein is performed. The AFM studies show that the controlled hydrolysis of casein by trypsine allows preparation of monodisperse nanoparticles with a mean size of 22 nm and...
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Veröffentlicht in: | Russian chemical bulletin 2018-08, Vol.67 (8), p.1508-1512 |
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creator | Vorob’ev, M. M. Khomenkov, V. S. Sinitsyna, O. V. Levinskaya, O. A. Kitaeva, D. Kh Kalistratova, A. V. Oshchepkov, M. S. Kovalenko, L. V. Kochetkov, K. A. |
description | Encapsulation of biologically active β-oxalylamino substituted
O
-ethylcarbamate in micelles of non-hydrolyzed and hydrolyzed casein is performed. The AFM studies show that the controlled hydrolysis of casein by trypsine allows preparation of monodisperse nanoparticles with a mean size of 22 nm and with a dispersion of 5 nm. The high-precision coulometric method for the chlorine detection shows that, as compared with initial casein micelles, the formed nanoparticles involve appreciable amounts of chlorine-containing alkylcarbamate. Micellar solubilization allows the preparation of the colloidal form of alkylcarbamate form, which is suitable for its practical application. |
doi_str_mv | 10.1007/s11172-018-2248-7 |
format | Article |
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O
-ethylcarbamate in micelles of non-hydrolyzed and hydrolyzed casein is performed. The AFM studies show that the controlled hydrolysis of casein by trypsine allows preparation of monodisperse nanoparticles with a mean size of 22 nm and with a dispersion of 5 nm. The high-precision coulometric method for the chlorine detection shows that, as compared with initial casein micelles, the formed nanoparticles involve appreciable amounts of chlorine-containing alkylcarbamate. Micellar solubilization allows the preparation of the colloidal form of alkylcarbamate form, which is suitable for its practical application.</description><identifier>ISSN: 1066-5285</identifier><identifier>EISSN: 1573-9171</identifier><identifier>DOI: 10.1007/s11172-018-2248-7</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Carbamates (tradename) ; Casein ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Chlorine ; Coulometers ; Encapsulation ; Hydrolysis ; Inorganic Chemistry ; Micelles ; Nanoparticles ; Organic Chemistry ; Solubilization</subject><ispartof>Russian chemical bulletin, 2018-08, Vol.67 (8), p.1508-1512</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Copyright Springer Science & Business Media 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-a392f147f978eff0b4fe361af45c3a9493d8d5af43bf03d99aafc69c7076ce833</citedby><cites>FETCH-LOGICAL-c316t-a392f147f978eff0b4fe361af45c3a9493d8d5af43bf03d99aafc69c7076ce833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11172-018-2248-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11172-018-2248-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Vorob’ev, M. M.</creatorcontrib><creatorcontrib>Khomenkov, V. S.</creatorcontrib><creatorcontrib>Sinitsyna, O. V.</creatorcontrib><creatorcontrib>Levinskaya, O. A.</creatorcontrib><creatorcontrib>Kitaeva, D. Kh</creatorcontrib><creatorcontrib>Kalistratova, A. V.</creatorcontrib><creatorcontrib>Oshchepkov, M. S.</creatorcontrib><creatorcontrib>Kovalenko, L. V.</creatorcontrib><creatorcontrib>Kochetkov, K. A.</creatorcontrib><title>Encapsulation of chlorine-containing carbamates in polypeptide nanoparticles prepared by enzymatic hydrolysis of casein</title><title>Russian chemical bulletin</title><addtitle>Russ Chem Bull</addtitle><description>Encapsulation of biologically active β-oxalylamino substituted
O
-ethylcarbamate in micelles of non-hydrolyzed and hydrolyzed casein is performed. The AFM studies show that the controlled hydrolysis of casein by trypsine allows preparation of monodisperse nanoparticles with a mean size of 22 nm and with a dispersion of 5 nm. The high-precision coulometric method for the chlorine detection shows that, as compared with initial casein micelles, the formed nanoparticles involve appreciable amounts of chlorine-containing alkylcarbamate. Micellar solubilization allows the preparation of the colloidal form of alkylcarbamate form, which is suitable for its practical application.</description><subject>Carbamates (tradename)</subject><subject>Casein</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Chlorine</subject><subject>Coulometers</subject><subject>Encapsulation</subject><subject>Hydrolysis</subject><subject>Inorganic Chemistry</subject><subject>Micelles</subject><subject>Nanoparticles</subject><subject>Organic Chemistry</subject><subject>Solubilization</subject><issn>1066-5285</issn><issn>1573-9171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kEtLxDAUhYMoOI7-AHcB19E82iZZyjA-QHCj65CmyUyGTlKTDlJ_vRkruHJ17-Ge71w4AFwTfEsw5neZEMIpwkQgSiuB-AlYkJozJAknp2XHTYNqKupzcJHzDmNMhRAL8LkORg_50OvRxwCjg2bbx-SDRSaGUfvgwwYanVq916PN0Ac4xH4a7DD6zsKgQxx0Gr3py3FItgjbwXaCNnxNBfEGbqcuFST7_JOvs_XhEpw53Wd79TuX4P1h_bZ6Qi-vj8-r-xdkGGlGpJmkjlTcSS6sc7itnGUN0a6qDdOykqwTXV0kax1mnZRaO9NIwzFvjBWMLcHNnDuk-HGweVS7eEihvFSU0KrGgrOmuMjsMinmnKxTQ_J7nSZFsDr2q-Z-VelXHftVvDB0ZnLxho1Nf8n_Q9_7sIE4</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Vorob’ev, M. M.</creator><creator>Khomenkov, V. S.</creator><creator>Sinitsyna, O. V.</creator><creator>Levinskaya, O. A.</creator><creator>Kitaeva, D. Kh</creator><creator>Kalistratova, A. V.</creator><creator>Oshchepkov, M. S.</creator><creator>Kovalenko, L. V.</creator><creator>Kochetkov, K. A.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20180801</creationdate><title>Encapsulation of chlorine-containing carbamates in polypeptide nanoparticles prepared by enzymatic hydrolysis of casein</title><author>Vorob’ev, M. M. ; Khomenkov, V. S. ; Sinitsyna, O. V. ; Levinskaya, O. A. ; Kitaeva, D. Kh ; Kalistratova, A. V. ; Oshchepkov, M. S. ; Kovalenko, L. V. ; Kochetkov, K. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-a392f147f978eff0b4fe361af45c3a9493d8d5af43bf03d99aafc69c7076ce833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Carbamates (tradename)</topic><topic>Casein</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Chlorine</topic><topic>Coulometers</topic><topic>Encapsulation</topic><topic>Hydrolysis</topic><topic>Inorganic Chemistry</topic><topic>Micelles</topic><topic>Nanoparticles</topic><topic>Organic Chemistry</topic><topic>Solubilization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vorob’ev, M. M.</creatorcontrib><creatorcontrib>Khomenkov, V. S.</creatorcontrib><creatorcontrib>Sinitsyna, O. V.</creatorcontrib><creatorcontrib>Levinskaya, O. A.</creatorcontrib><creatorcontrib>Kitaeva, D. Kh</creatorcontrib><creatorcontrib>Kalistratova, A. V.</creatorcontrib><creatorcontrib>Oshchepkov, M. S.</creatorcontrib><creatorcontrib>Kovalenko, L. V.</creatorcontrib><creatorcontrib>Kochetkov, K. A.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian chemical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vorob’ev, M. M.</au><au>Khomenkov, V. S.</au><au>Sinitsyna, O. V.</au><au>Levinskaya, O. A.</au><au>Kitaeva, D. Kh</au><au>Kalistratova, A. V.</au><au>Oshchepkov, M. S.</au><au>Kovalenko, L. V.</au><au>Kochetkov, K. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Encapsulation of chlorine-containing carbamates in polypeptide nanoparticles prepared by enzymatic hydrolysis of casein</atitle><jtitle>Russian chemical bulletin</jtitle><stitle>Russ Chem Bull</stitle><date>2018-08-01</date><risdate>2018</risdate><volume>67</volume><issue>8</issue><spage>1508</spage><epage>1512</epage><pages>1508-1512</pages><issn>1066-5285</issn><eissn>1573-9171</eissn><abstract>Encapsulation of biologically active β-oxalylamino substituted
O
-ethylcarbamate in micelles of non-hydrolyzed and hydrolyzed casein is performed. The AFM studies show that the controlled hydrolysis of casein by trypsine allows preparation of monodisperse nanoparticles with a mean size of 22 nm and with a dispersion of 5 nm. The high-precision coulometric method for the chlorine detection shows that, as compared with initial casein micelles, the formed nanoparticles involve appreciable amounts of chlorine-containing alkylcarbamate. Micellar solubilization allows the preparation of the colloidal form of alkylcarbamate form, which is suitable for its practical application.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11172-018-2248-7</doi><tpages>5</tpages></addata></record> |
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subjects | Carbamates (tradename) Casein Chemistry Chemistry and Materials Science Chemistry/Food Science Chlorine Coulometers Encapsulation Hydrolysis Inorganic Chemistry Micelles Nanoparticles Organic Chemistry Solubilization |
title | Encapsulation of chlorine-containing carbamates in polypeptide nanoparticles prepared by enzymatic hydrolysis of casein |
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