Encapsulation of chlorine-containing carbamates in polypeptide nanoparticles prepared by enzymatic hydrolysis of casein

Encapsulation of biologically active β-oxalylamino substituted O -ethylcarbamate in micelles of non-hydrolyzed and hydrolyzed casein is performed. The AFM studies show that the controlled hydrolysis of casein by trypsine allows preparation of monodisperse nanoparticles with a mean size of 22 nm and...

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Veröffentlicht in:Russian chemical bulletin 2018-08, Vol.67 (8), p.1508-1512
Hauptverfasser: Vorob’ev, M. M., Khomenkov, V. S., Sinitsyna, O. V., Levinskaya, O. A., Kitaeva, D. Kh, Kalistratova, A. V., Oshchepkov, M. S., Kovalenko, L. V., Kochetkov, K. A.
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container_end_page 1512
container_issue 8
container_start_page 1508
container_title Russian chemical bulletin
container_volume 67
creator Vorob’ev, M. M.
Khomenkov, V. S.
Sinitsyna, O. V.
Levinskaya, O. A.
Kitaeva, D. Kh
Kalistratova, A. V.
Oshchepkov, M. S.
Kovalenko, L. V.
Kochetkov, K. A.
description Encapsulation of biologically active β-oxalylamino substituted O -ethylcarbamate in micelles of non-hydrolyzed and hydrolyzed casein is performed. The AFM studies show that the controlled hydrolysis of casein by trypsine allows preparation of monodisperse nanoparticles with a mean size of 22 nm and with a dispersion of 5 nm. The high-precision coulometric method for the chlorine detection shows that, as compared with initial casein micelles, the formed nanoparticles involve appreciable amounts of chlorine-containing alkylcarbamate. Micellar solubilization allows the preparation of the colloidal form of alkylcarbamate form, which is suitable for its practical application.
doi_str_mv 10.1007/s11172-018-2248-7
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subjects Carbamates (tradename)
Casein
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Chlorine
Coulometers
Encapsulation
Hydrolysis
Inorganic Chemistry
Micelles
Nanoparticles
Organic Chemistry
Solubilization
title Encapsulation of chlorine-containing carbamates in polypeptide nanoparticles prepared by enzymatic hydrolysis of casein
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