In vivo effects of radioactive properties of Tl-201 on human carbonic anhydrase activity
Carbonic anhydrase (CA) is a family of metalloenzymes that requires Zn as a cofactor and catalyze the quick conversion of CO2 to HCO3 − and H+. Inhibitors of the carbonic anhydrases (CAs) have medical usage of significant diseases such as glaucoma, epilepsy, gastroduodenal ulcers, acid-base disequil...
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| creator | Sahin, Ali Senturk, Murat |
| description | Carbonic anhydrase (CA) is a family of metalloenzymes that requires Zn as a cofactor and catalyze the quick conversion of CO2 to HCO3
− and H+. Inhibitors of the carbonic anhydrases (CAs) have medical usage of significant diseases such as glaucoma, epilepsy, gastroduodenal ulcers, acid-base disequilibria and neurological disorders. The most useful radioisotope, Tl-201, decays by electron capture, emitting Hg X-rays (~70–80 keV), and photons of 135 and 167 keV in 10% total abundance. Therefore, it has good imaging characteristics without excessive patient radiation dose. It is the most popular isotope used for thallium 201 nuclear cardiac stress tests. In the present study, In vivo inhibitory effect of Tl-201 (Thallium-201) on human erythrocyte carbonic anhydrase (CA) activity were investigated. |
| doi_str_mv | 10.1063/1.4981757 |
| format | Conference Proceeding |
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− and H+. Inhibitors of the carbonic anhydrases (CAs) have medical usage of significant diseases such as glaucoma, epilepsy, gastroduodenal ulcers, acid-base disequilibria and neurological disorders. The most useful radioisotope, Tl-201, decays by electron capture, emitting Hg X-rays (~70–80 keV), and photons of 135 and 167 keV in 10% total abundance. Therefore, it has good imaging characteristics without excessive patient radiation dose. It is the most popular isotope used for thallium 201 nuclear cardiac stress tests. In the present study, In vivo inhibitory effect of Tl-201 (Thallium-201) on human erythrocyte carbonic anhydrase (CA) activity were investigated.</description><identifier>ISSN: 0094-243X</identifier><identifier>EISSN: 1551-7616</identifier><identifier>DOI: 10.1063/1.4981757</identifier><identifier>CODEN: APCPCS</identifier><language>eng</language><publisher>Melville: American Institute of Physics</publisher><subject>Beta decay ; Carbonic anhydrase ; Electron capture ; Epilepsy ; Erythrocytes ; Glaucoma ; In vivo methods and tests ; Ion exchange ; Photons ; Radiation dosage ; Radioisotopes ; Thallium ; Ulcers</subject><ispartof>AIP Conference Proceedings, 2017, Vol.1833 (1)</ispartof><rights>Author(s)</rights><rights>2017 Author(s). Published by AIP Publishing.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://pubs.aip.org/acp/article-lookup/doi/10.1063/1.4981757$$EHTML$$P50$$Gscitation$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,794,4512,23930,23931,25140,27924,27925,76384</link.rule.ids></links><search><contributor>Akdemir, Ahmet Ocak</contributor><contributor>Han, Ibrahim</contributor><contributor>Oztekin, Aykut</contributor><contributor>Set, Erhan</contributor><contributor>Dadasoglu, Fatih</contributor><contributor>Karagoz, Kenan</contributor><contributor>Ekinci, Alper</contributor><creatorcontrib>Sahin, Ali</creatorcontrib><creatorcontrib>Senturk, Murat</creatorcontrib><title>In vivo effects of radioactive properties of Tl-201 on human carbonic anhydrase activity</title><title>AIP Conference Proceedings</title><description>Carbonic anhydrase (CA) is a family of metalloenzymes that requires Zn as a cofactor and catalyze the quick conversion of CO2 to HCO3
− and H+. Inhibitors of the carbonic anhydrases (CAs) have medical usage of significant diseases such as glaucoma, epilepsy, gastroduodenal ulcers, acid-base disequilibria and neurological disorders. The most useful radioisotope, Tl-201, decays by electron capture, emitting Hg X-rays (~70–80 keV), and photons of 135 and 167 keV in 10% total abundance. Therefore, it has good imaging characteristics without excessive patient radiation dose. It is the most popular isotope used for thallium 201 nuclear cardiac stress tests. In the present study, In vivo inhibitory effect of Tl-201 (Thallium-201) on human erythrocyte carbonic anhydrase (CA) activity were investigated.</description><subject>Beta decay</subject><subject>Carbonic anhydrase</subject><subject>Electron capture</subject><subject>Epilepsy</subject><subject>Erythrocytes</subject><subject>Glaucoma</subject><subject>In vivo methods and tests</subject><subject>Ion exchange</subject><subject>Photons</subject><subject>Radiation dosage</subject><subject>Radioisotopes</subject><subject>Thallium</subject><subject>Ulcers</subject><issn>0094-243X</issn><issn>1551-7616</issn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2017</creationdate><recordtype>conference_proceeding</recordtype><recordid>eNp9kMFKAzEQhoMoWKsH3yDgTdg6STbJ7lGK1kLBS4XeQrpJaEqbrNl0oW_v2ha8eZrDfN8_w4_QI4EJAcFeyKSsKyK5vEIjwjkppCDiGo0A6rKgJVvdoruu2wLQWspqhFbzgHvfR2yds03ucHQ4aeOjbrLvLW5TbG3K3p42y11BgeAY8Oaw1wE3Oq1j8A3WYXM0SXcWnzyfj_foxuldZx8uc4y-3t-W049i8TmbT18XRUs5y0XN185V0kgmSO2oBaodJU4LI6lla8qBEjMwzAjJuaAVVA0HcLoGqankbIyezrnDp98H22W1jYcUhpOKEloOPqvEQD2fqa7xWWcfg2qT3-t0VH1MiqhLa6o17j-YgPqt-U9gP1zWbfE</recordid><startdate>20170425</startdate><enddate>20170425</enddate><creator>Sahin, Ali</creator><creator>Senturk, Murat</creator><general>American Institute of Physics</general><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope></search><sort><creationdate>20170425</creationdate><title>In vivo effects of radioactive properties of Tl-201 on human carbonic anhydrase activity</title><author>Sahin, Ali ; Senturk, Murat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p253t-95bff87d73619f2e02af21fa6d72e3b25021d5bf3d675562808c500fa907a2753</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Beta decay</topic><topic>Carbonic anhydrase</topic><topic>Electron capture</topic><topic>Epilepsy</topic><topic>Erythrocytes</topic><topic>Glaucoma</topic><topic>In vivo methods and tests</topic><topic>Ion exchange</topic><topic>Photons</topic><topic>Radiation dosage</topic><topic>Radioisotopes</topic><topic>Thallium</topic><topic>Ulcers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sahin, Ali</creatorcontrib><creatorcontrib>Senturk, Murat</creatorcontrib><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sahin, Ali</au><au>Senturk, Murat</au><au>Akdemir, Ahmet Ocak</au><au>Han, Ibrahim</au><au>Oztekin, Aykut</au><au>Set, Erhan</au><au>Dadasoglu, Fatih</au><au>Karagoz, Kenan</au><au>Ekinci, Alper</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>In vivo effects of radioactive properties of Tl-201 on human carbonic anhydrase activity</atitle><btitle>AIP Conference Proceedings</btitle><date>2017-04-25</date><risdate>2017</risdate><volume>1833</volume><issue>1</issue><issn>0094-243X</issn><eissn>1551-7616</eissn><coden>APCPCS</coden><abstract>Carbonic anhydrase (CA) is a family of metalloenzymes that requires Zn as a cofactor and catalyze the quick conversion of CO2 to HCO3
− and H+. Inhibitors of the carbonic anhydrases (CAs) have medical usage of significant diseases such as glaucoma, epilepsy, gastroduodenal ulcers, acid-base disequilibria and neurological disorders. The most useful radioisotope, Tl-201, decays by electron capture, emitting Hg X-rays (~70–80 keV), and photons of 135 and 167 keV in 10% total abundance. Therefore, it has good imaging characteristics without excessive patient radiation dose. It is the most popular isotope used for thallium 201 nuclear cardiac stress tests. In the present study, In vivo inhibitory effect of Tl-201 (Thallium-201) on human erythrocyte carbonic anhydrase (CA) activity were investigated.</abstract><cop>Melville</cop><pub>American Institute of Physics</pub><doi>10.1063/1.4981757</doi><tpages>3</tpages></addata></record> |
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| ispartof | AIP Conference Proceedings, 2017, Vol.1833 (1) |
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| language | eng |
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| source | AIP Journals Complete |
| subjects | Beta decay Carbonic anhydrase Electron capture Epilepsy Erythrocytes Glaucoma In vivo methods and tests Ion exchange Photons Radiation dosage Radioisotopes Thallium Ulcers |
| title | In vivo effects of radioactive properties of Tl-201 on human carbonic anhydrase activity |
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