Role of Cytoplasmic Tail of the Type 1A Angiotensin II Receptor in Agonist- and Phorbol Ester-Induced Desensitization

To investigate mechanisms underlying the agonist-induced desensitization of the type 1A angiotensin II receptor (AT1A-R), we have stably expressed in Chinese hamster ovary (CHO) cells the wild-type receptor and truncated mutants lacking varying lengths of the cytoplasmic tail. Assay of inositol 1,4,...

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Veröffentlicht in:	Circulation research 1998-03, Vol.82 (5), p.523-531
Hauptverfasser:	Tang, Hua, Guo, Deng Fu, Porter, James P, Wanaka, Yoshio, Inagami, Tadashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals beta-Adrenergic Receptor Kinases Biological and medical sciences Carcinogens - pharmacology Cell receptors Cell structures and functions CHO Cells - chemistry CHO Cells - enzymology Cricetinae Cyclic AMP-Dependent Protein Kinases - metabolism Fundamental and applied biological sciences. Psychology G-Protein-Coupled Receptor Kinase 3 G-Protein-Coupled Receptor Kinases GTP-Binding Proteins - physiology Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Inositol 1,4,5-Trisphosphate - metabolism Ion Channel Gating - drug effects Molecular and cellular biology Molecular Sequence Data Mutagenesis - physiology Phosphorylation Protein Structure, Tertiary Protein-Serine-Threonine Kinases - physiology Rats Receptor Protein-Tyrosine Kinases - metabolism Receptors, Angiotensin - agonists Receptors, Angiotensin - chemistry Receptors, Angiotensin - genetics Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Tetradecanoylphorbol Acetate - pharmacology Thioredoxins - genetics Thioredoxins - metabolism
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