Activated Protein Kinase C Isoforms Target to Cardiomyocyte Caveolae: Stimulation of Local Protein Phosphorylation

Protein kinase C (PKC) isoforms constitute an important component of the signal transduction pathway used by cardiomyocytes to respond to a variety of extracellular stimuli. Translocation to distinct intracellular sites represents an essential step in the activation of PKC isoforms, presumably as a...

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Veröffentlicht in:	Circulation research 1999-05, Vol.84 (9), p.980-988
Hauptverfasser:	Rybin, Vitalyi O, Xu, Xiaohong, Steinberg, Susan F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Transport - drug effects Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Membrane - drug effects Cell Membrane - metabolism Cell Membrane - ultrastructure Endothelins - pharmacology Enzyme Activation - physiology Fundamental and applied biological sciences. Psychology Heart Isoenzymes - metabolism Membrane Proteins - metabolism Mitogen-Activated Protein Kinase Kinases Myocardium - cytology Myocardium - enzymology Phosphorylation Protein Kinase C - metabolism Protein Kinases - metabolism Rats Rats, Wistar Signal Transduction - physiology Tetradecanoylphorbol Acetate - pharmacology Vertebrates: cardiovascular system
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