Hypoxia/Reoxygenation Stimulates Jun Kinase Activity Through Redox Signaling in Cardiac Myocytes

Hypoxia and reoxygenation are principal components of myocardial ischemia and reperfusion and have distinctive effects on the tissue. Both conditions have been associated with inflammation, necrosis, apoptosis, and myocardial infarction. Using a cell culture model of ischemia and reperfusion in whic...

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Veröffentlicht in:	Circulation research 1997-03, Vol.80 (3), p.336-344
Hauptverfasser:	Laderoute, Keith R, Webster, Keith A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anisomycin - pharmacology Antioxidants - pharmacology Biological and medical sciences Blotting, Western Buthionine Sulfoximine - pharmacology Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cardiology. Vascular system Cell Hypoxia Cells, Cultured Coronary heart disease Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Fibroblasts Genistein Glutathione - analogs & derivatives Heart Heart - drug effects Isoflavones - pharmacology JNK Mitogen-Activated Protein Kinases Medical sciences Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases Myocardium - enzymology Okadaic Acid - pharmacology Oxidation-Reduction Oxygen - metabolism Oxygen - pharmacology Protein Synthesis Inhibitors - pharmacology Protein-Tyrosine Kinases - antagonists & inhibitors Rats Reactive Oxygen Species - physiology Time Factors
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