Utilization of iPSC-derived human neurons for high-throughput drug-induced peripheral neuropathy screening

As the number of cancer survivors continues to grow, awareness of long-term toxicities and impact on quality of life after chemotherapy treatment in cancer survivors has intensified. Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common side effects of modern chemotherapy. Anim...

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Veröffentlicht in:	Toxicology in vitro 2017-12, Vol.45 (Pt 1), p.111-118
Hauptverfasser:	Rana, Payal, Luerman, Gregory, Hess, Dietmar, Rubitski, Elizabeth, Adkins, Karissa, Somps, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Angiogenesis Animal models Antineoplastic Agents - toxicity Cancer Chemotherapy Cytology High-throughput screening High-Throughput Screening Assays Humans Induced Pluripotent Stem Cells Liability Mathematical models Medical screening Model testing Morphology Neurites - drug effects Neurons Neurons - drug effects Neurons - physiology Neurotoxicity Neurotoxicity Syndromes Peripheral Nervous System Diseases - chemically induced Peripheral neuropathy Platinum Proteasome inhibitors Quality of life Screening Side effects Stem cells Taxanes
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