Synthesis and Anti-Inflammatory Activity of 6-(Substituted Acridin-9-Yl Amino)-2,3-Dihydro -3-Thioxo-[1,2,4] Triazolo [4,3-F][1,2,4] Triazin-8 (5h)-One

Synthesis and Anti-Inflammatory Activity of 6-(Substituted Acridin-9-Yl Amino)-2,3-Dihydro -3-Thioxo-[1,2,4] Triazolo [4,3-F][1,2,4] Triazin-8 (5h)-One

A new series of 6-(substituted acridin-9-yl amino)-2,3-dihydro-3-thioxo- [1,2,4] triazolo [4,3-f][1,2,4] triazin-8 (5H)-one were synthesized from the reaction of 9-chloro acridine and 6-amino-2,3-dihydro-3-thioxo-[1,2,4]triazolo[4,3-f][1,2,4]triazin-8(5H)-one. The structures of the compounds were co...

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Veröffentlicht in:Oriental journal of chemistry 2008-09, Vol.24 (3), p.1053
Hauptverfasser: Nagarajan, G, Anush, K V S, Mahesh, A, B L V M Spandana, Saminathan, K, Balasubramaniam, V, Manjunath, K S
Format: Artikel
Sprache:eng
Schlagworte:
Chemical analysis
Chemical synthesis
NMR
Nuclear magnetic resonance
Protease inhibitors
Substitutes
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Zusammenfassung:A new series of 6-(substituted acridin-9-yl amino)-2,3-dihydro-3-thioxo- [1,2,4] triazolo [4,3-f][1,2,4] triazin-8 (5H)-one were synthesized from the reaction of 9-chloro acridine and 6-amino-2,3-dihydro-3-thioxo-[1,2,4]triazolo[4,3-f][1,2,4]triazin-8(5H)-one. The structures of the compounds were confirmed by IR, 1H NMR, Mass and CHN analysis. These compounds were evaluated for anti-inflammatory activity; compound 3b and 3c exhibited good anti inflammatory activity.
ISSN:0970-020X
2231-5039