New clearance evaluation method for hepatological diagnostics
Pulse dye densitometry (PDD) enables the evaluation of hemodynamic state as well as liver function. A repeated examination, even after a short pause (or under stress condition), enables to follow safely the dynamics of liver pathology. From presented parameters we have evaluated as reliable the C5-c...
Gespeichert in:
| Veröffentlicht in: | Physiological research 2009-01, Vol.58 (2), p.287-292 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 292 |
|---|---|
| container_issue | 2 |
| container_start_page | 287 |
| container_title | Physiological research |
| container_volume | 58 |
| creator | Tichý, J A Loucka, M Trefný, Z M Hojerová, M Svacinka, J Müller, J Friedrichová, M |
| description | Pulse dye densitometry (PDD) enables the evaluation of hemodynamic state as well as liver function. A repeated examination, even after a short pause (or under stress condition), enables to follow safely the dynamics of liver pathology. From presented parameters we have evaluated as reliable the C5-clearance, an expression of equilibrium state in the two compartment liver system. Furthermore, T-index expresses ratio of C5 value to cardiac output, it is a sensitive indicator of the blood pole, i.e. sinusoidal uptake, which is in very good correlation with staging of hepatopathies. The isolated h constant in correlation to T-index is valuable For functional grading. The Japanese automatic analyzer of indocyanine green (ICG) dilution and elimination curves, after incorporation of a two compartment mathematical model, becomes more useful for complex hepatological diagnostics. Non-invasive PDD is becoming of uppermost importance to clinical interest, yielding comparable results as other complicated and invasive examinations and may be, therefore, repeated in short time intervals for different indications with minimal stress of examined patient. |
| doi_str_mv | 10.33549/physiolres.931254 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_212231658</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1711560821</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-94e16f75e43f0e9eec2832bfa16588afc60443c806b667b5c8907a3fd9d107b53</originalsourceid><addsrcrecordid>eNpFkEtLw0AUhQdRbK3-ARcS3KfOK_NYuJDiC4pudD1MJnfalDQTZxKl_95oC11dDpzzXfgQuiZ4zljB9V233qU6NBHSXDNCC36CpkRhmmst2SmaYiVorjhWE3SR0gZjKrFk52hCpOaaFniK7t_gJ3MN2GhbBxl822awfR3abAv9OlSZDzFbQ2f70IRV7WyTVbVdtSH1tUuX6MzbJsHV4c7Q59Pjx-IlX74_vy4elrljkva55kCElwVw5jFoAEcVo6W3RBRKWe8E5pw5hUUphCwLpzSWlvlKVwSPmc3Q7Z7bxfA1QOrNJgyxHV8aSihlf5yxRPclF0NKEbzpYr21cWcINv_CzFGY2QsbRzcH8lBuoTpODobYL6tUabA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>212231658</pqid></control><display><type>article</type><title>New clearance evaluation method for hepatological diagnostics</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Tichý, J A ; Loucka, M ; Trefný, Z M ; Hojerová, M ; Svacinka, J ; Müller, J ; Friedrichová, M</creator><creatorcontrib>Tichý, J A ; Loucka, M ; Trefný, Z M ; Hojerová, M ; Svacinka, J ; Müller, J ; Friedrichová, M</creatorcontrib><description>Pulse dye densitometry (PDD) enables the evaluation of hemodynamic state as well as liver function. A repeated examination, even after a short pause (or under stress condition), enables to follow safely the dynamics of liver pathology. From presented parameters we have evaluated as reliable the C5-clearance, an expression of equilibrium state in the two compartment liver system. Furthermore, T-index expresses ratio of C5 value to cardiac output, it is a sensitive indicator of the blood pole, i.e. sinusoidal uptake, which is in very good correlation with staging of hepatopathies. The isolated h constant in correlation to T-index is valuable For functional grading. The Japanese automatic analyzer of indocyanine green (ICG) dilution and elimination curves, after incorporation of a two compartment mathematical model, becomes more useful for complex hepatological diagnostics. Non-invasive PDD is becoming of uppermost importance to clinical interest, yielding comparable results as other complicated and invasive examinations and may be, therefore, repeated in short time intervals for different indications with minimal stress of examined patient.</description><identifier>ISSN: 0862-8408</identifier><identifier>EISSN: 1802-9973</identifier><identifier>DOI: 10.33549/physiolres.931254</identifier><identifier>PMID: 17949250</identifier><language>eng</language><publisher>Czech Republic: Institute of Physiology</publisher><subject>Adult ; Aged ; Body Fluid Compartments ; Cardiac Output ; Coloring Agents - pharmacokinetics ; Confidence intervals ; Conflicts of interest ; Densitometry - methods ; Densitometry - standards ; Fatty Liver - diagnosis ; Fatty Liver - metabolism ; Female ; Humans ; Indocyanine Green - pharmacokinetics ; Liver diseases ; Liver Function Tests - methods ; Liver Function Tests - standards ; Male ; Mathematical models ; Middle Aged ; Models, Biological ; Nonlinear Dynamics ; Regression Analysis ; Reproducibility of Results ; Young Adult</subject><ispartof>Physiological research, 2009-01, Vol.58 (2), p.287-292</ispartof><rights>Copyright Institute of Physiology 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-94e16f75e43f0e9eec2832bfa16588afc60443c806b667b5c8907a3fd9d107b53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17949250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tichý, J A</creatorcontrib><creatorcontrib>Loucka, M</creatorcontrib><creatorcontrib>Trefný, Z M</creatorcontrib><creatorcontrib>Hojerová, M</creatorcontrib><creatorcontrib>Svacinka, J</creatorcontrib><creatorcontrib>Müller, J</creatorcontrib><creatorcontrib>Friedrichová, M</creatorcontrib><title>New clearance evaluation method for hepatological diagnostics</title><title>Physiological research</title><addtitle>Physiol Res</addtitle><description>Pulse dye densitometry (PDD) enables the evaluation of hemodynamic state as well as liver function. A repeated examination, even after a short pause (or under stress condition), enables to follow safely the dynamics of liver pathology. From presented parameters we have evaluated as reliable the C5-clearance, an expression of equilibrium state in the two compartment liver system. Furthermore, T-index expresses ratio of C5 value to cardiac output, it is a sensitive indicator of the blood pole, i.e. sinusoidal uptake, which is in very good correlation with staging of hepatopathies. The isolated h constant in correlation to T-index is valuable For functional grading. The Japanese automatic analyzer of indocyanine green (ICG) dilution and elimination curves, after incorporation of a two compartment mathematical model, becomes more useful for complex hepatological diagnostics. Non-invasive PDD is becoming of uppermost importance to clinical interest, yielding comparable results as other complicated and invasive examinations and may be, therefore, repeated in short time intervals for different indications with minimal stress of examined patient.</description><subject>Adult</subject><subject>Aged</subject><subject>Body Fluid Compartments</subject><subject>Cardiac Output</subject><subject>Coloring Agents - pharmacokinetics</subject><subject>Confidence intervals</subject><subject>Conflicts of interest</subject><subject>Densitometry - methods</subject><subject>Densitometry - standards</subject><subject>Fatty Liver - diagnosis</subject><subject>Fatty Liver - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Indocyanine Green - pharmacokinetics</subject><subject>Liver diseases</subject><subject>Liver Function Tests - methods</subject><subject>Liver Function Tests - standards</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Middle Aged</subject><subject>Models, Biological</subject><subject>Nonlinear Dynamics</subject><subject>Regression Analysis</subject><subject>Reproducibility of Results</subject><subject>Young Adult</subject><issn>0862-8408</issn><issn>1802-9973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpFkEtLw0AUhQdRbK3-ARcS3KfOK_NYuJDiC4pudD1MJnfalDQTZxKl_95oC11dDpzzXfgQuiZ4zljB9V233qU6NBHSXDNCC36CpkRhmmst2SmaYiVorjhWE3SR0gZjKrFk52hCpOaaFniK7t_gJ3MN2GhbBxl822awfR3abAv9OlSZDzFbQ2f70IRV7WyTVbVdtSH1tUuX6MzbJsHV4c7Q59Pjx-IlX74_vy4elrljkva55kCElwVw5jFoAEcVo6W3RBRKWe8E5pw5hUUphCwLpzSWlvlKVwSPmc3Q7Z7bxfA1QOrNJgyxHV8aSihlf5yxRPclF0NKEbzpYr21cWcINv_CzFGY2QsbRzcH8lBuoTpODobYL6tUabA</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Tichý, J A</creator><creator>Loucka, M</creator><creator>Trefný, Z M</creator><creator>Hojerová, M</creator><creator>Svacinka, J</creator><creator>Müller, J</creator><creator>Friedrichová, M</creator><general>Institute of Physiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20090101</creationdate><title>New clearance evaluation method for hepatological diagnostics</title><author>Tichý, J A ; Loucka, M ; Trefný, Z M ; Hojerová, M ; Svacinka, J ; Müller, J ; Friedrichová, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-94e16f75e43f0e9eec2832bfa16588afc60443c806b667b5c8907a3fd9d107b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Body Fluid Compartments</topic><topic>Cardiac Output</topic><topic>Coloring Agents - pharmacokinetics</topic><topic>Confidence intervals</topic><topic>Conflicts of interest</topic><topic>Densitometry - methods</topic><topic>Densitometry - standards</topic><topic>Fatty Liver - diagnosis</topic><topic>Fatty Liver - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Indocyanine Green - pharmacokinetics</topic><topic>Liver diseases</topic><topic>Liver Function Tests - methods</topic><topic>Liver Function Tests - standards</topic><topic>Male</topic><topic>Mathematical models</topic><topic>Middle Aged</topic><topic>Models, Biological</topic><topic>Nonlinear Dynamics</topic><topic>Regression Analysis</topic><topic>Reproducibility of Results</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tichý, J A</creatorcontrib><creatorcontrib>Loucka, M</creatorcontrib><creatorcontrib>Trefný, Z M</creatorcontrib><creatorcontrib>Hojerová, M</creatorcontrib><creatorcontrib>Svacinka, J</creatorcontrib><creatorcontrib>Müller, J</creatorcontrib><creatorcontrib>Friedrichová, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Physiological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tichý, J A</au><au>Loucka, M</au><au>Trefný, Z M</au><au>Hojerová, M</au><au>Svacinka, J</au><au>Müller, J</au><au>Friedrichová, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New clearance evaluation method for hepatological diagnostics</atitle><jtitle>Physiological research</jtitle><addtitle>Physiol Res</addtitle><date>2009-01-01</date><risdate>2009</risdate><volume>58</volume><issue>2</issue><spage>287</spage><epage>292</epage><pages>287-292</pages><issn>0862-8408</issn><eissn>1802-9973</eissn><abstract>Pulse dye densitometry (PDD) enables the evaluation of hemodynamic state as well as liver function. A repeated examination, even after a short pause (or under stress condition), enables to follow safely the dynamics of liver pathology. From presented parameters we have evaluated as reliable the C5-clearance, an expression of equilibrium state in the two compartment liver system. Furthermore, T-index expresses ratio of C5 value to cardiac output, it is a sensitive indicator of the blood pole, i.e. sinusoidal uptake, which is in very good correlation with staging of hepatopathies. The isolated h constant in correlation to T-index is valuable For functional grading. The Japanese automatic analyzer of indocyanine green (ICG) dilution and elimination curves, after incorporation of a two compartment mathematical model, becomes more useful for complex hepatological diagnostics. Non-invasive PDD is becoming of uppermost importance to clinical interest, yielding comparable results as other complicated and invasive examinations and may be, therefore, repeated in short time intervals for different indications with minimal stress of examined patient.</abstract><cop>Czech Republic</cop><pub>Institute of Physiology</pub><pmid>17949250</pmid><doi>10.33549/physiolres.931254</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0862-8408 |
| ispartof | Physiological research, 2009-01, Vol.58 (2), p.287-292 |
| issn | 0862-8408 1802-9973 |
| language | eng |
| recordid | cdi_proquest_journals_212231658 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Body Fluid Compartments Cardiac Output Coloring Agents - pharmacokinetics Confidence intervals Conflicts of interest Densitometry - methods Densitometry - standards Fatty Liver - diagnosis Fatty Liver - metabolism Female Humans Indocyanine Green - pharmacokinetics Liver diseases Liver Function Tests - methods Liver Function Tests - standards Male Mathematical models Middle Aged Models, Biological Nonlinear Dynamics Regression Analysis Reproducibility of Results Young Adult |
| title | New clearance evaluation method for hepatological diagnostics |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T11%3A34%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%20clearance%20evaluation%20method%20for%20hepatological%20diagnostics&rft.jtitle=Physiological%20research&rft.au=Tich%C3%BD,%20J%20A&rft.date=2009-01-01&rft.volume=58&rft.issue=2&rft.spage=287&rft.epage=292&rft.pages=287-292&rft.issn=0862-8408&rft.eissn=1802-9973&rft_id=info:doi/10.33549/physiolres.931254&rft_dat=%3Cproquest_cross%3E1711560821%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=212231658&rft_id=info:pmid/17949250&rfr_iscdi=true |